受非平稳地震作用的密肋复合墙体的可靠度分析

通过数值计算对受非平稳随机地震作用的密肋复合墙体的动力可靠度进行分析.首先将随机地震动模型表示为均匀调制的非平稳地震动模型,通过振型叠加法求出随机地震反应的功率谱密度和均方值;其次应用首次超越破坏准则给出结构随机地震反应动力可靠度的具体计算公式,并给出结构在弹塑性状态时的界限值;最后对有限元建模时视为实体模型的单层密肋复合墙体与同模型尺寸的框架和剪力墙的动力可靠度进行了计算,对比分析了3种结构在多遇地震和罕遇地震作用下的动力可靠度.结果表明,密肋复合墙体的动力可靠度介于框架与剪力墙之间,密肋壁板结构是一种安全可靠的新型结构.     

Subtypes of medulloblastoma have distinct developmental origins

Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour subtypes that together comprise the most common malignant childhood brain tumour. These tumours are thought to arise within the cerebellum, with approximately 25% originating from granule neuron precursor cells (GNPCs) after aberrant activation of the Sonic Hedgehog pathway (hereafter, SHH subtype). The pathological processes that drive heterogeneity among the other medulloblastoma subtypes are not known, hindering the development of much needed new therapies. Here we provide evidence that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem. We found that genes marking human WNT-subtype medulloblastomas are more frequently expressed in the lower rhombic lip (LRL) and embryonic dorsal brainstem than in the upper rhombic lip (URL) and developing cerebellum. Magnetic resonance imaging (MRI) and intra-operative reports showed that human WNT-subtype tumours infiltrate the dorsal brainstem, whereas SHH-subtype tumours are located within the cerebellar hemispheres. Activating mutations in Ctnnb1 had little impact on progenitor cell populations in the cerebellum, but caused the abnormal accumulation of cells on the embryonic dorsal brainstem which included aberrantly proliferating Zic1(+) precursor cells. These lesions persisted in all mutant adult mice; moreover, in 15% of cases in which Tp53 was concurrently deleted, they progressed to form medulloblastomas that recapitulated the anatomy and gene expression profiles of human WNT-subtype medulloblastoma. We provide the first evidence, to our knowledge, that subtypes of medulloblastoma have distinct cellular origins. Our data provide an explanation for the marked molecular and clinical differences between SHH- and WNT-subtype medulloblastomas and have profound implications for future research and treatment of this important childhood cancer.     

某公路桥梁墩台的强度分析

通过研究桥梁墩台结构特点和载荷,分析了桥梁墩台的受力情况,并进行了计算。研究表明：在桥墩所受横向载荷中风载荷的影响相对与水流的侧压力比较小,可以忽略。所以在进行分析的时候只考虑水流的侧压力对桥墩强度的影响。以某公路桥梁墩台为例,利用ANSYS对结构及其强度进行了分析。     

浅淡英语教师的教学能力

文章分析了英语教师日常课堂教学应具备的基本素质 ,包括传授和培养外语知识技能的能力和外语教学的组织能力以及信息时代应掌握的教学新技术等。进而提出在网络环境中英语教师教学能力提高的相关诸多能力的有意识培养 ,是英语教师教学能力提高和进一步发挥的根本保障     

Research at channel level on the effect of LaCl3 on Radish (Raphanus satirus L.) vacuolar membrane

We recorded slow vacuolar (SV-type) channel currents of Radish vacuoles successfully for the first time by using the whole-vacuolar patch-clamp recording mode. SVtrye currents would increase and threshold potentials of activation would shift towards more negative values with the increase of concentrations of cytosolic Ca2+. When 2.5 mmol/L LaCl3 and 4 mmol/L EGTA were added to bath solutions,SV-type currents were suppressed remarkably. Then adding LaCl3 with different concentrations to pipette solutions, we found that LaCl3 with higher concentrations (＞ 4 × 10-7 mol/L)had a strong inhibitory effect on SV-type currents, while LaCl3 with lower concentrations (≤4 × 10-7 mol/L) promoted channel currents. This promoting effect provides an important basis at channel level for researching further the effects of rare earth on physiological activities of plants and the production-increase effects of rare earth fertilizers on crops.``     

115m跨度钢筋混凝土拱结构施工质量控制

针对大跨度拱结构施工中涉及的施工段划分、施工缝留设、预拱度计算、结构预压、模板及支撑体系设计等技术问题,结合工程实践和现场应力应变监测分析,介绍了大跨度拱结构施工工艺和质量控制关键,提出了采用"免预压法"对于保证大跨度钢筋砼拱结构施工质量的成功经验和借鉴意义。     

冷再生技术在高等级公路中的应用

通过试验，分析冷再生料的物理特性及施工中的材料级配问题，阐述冷再生技术的基本原理，介绍冷再生技术在高等级公路中的应用。     

程潮铁矿联合开采时回采顺序的数值模拟优化

程潮铁矿的矿体随着开采深度的增加而逐渐西移,导致选矿车间下保安矿柱所占矿量不断增多,故拟采用联合开采方法回收-430~-500m阶段矿体:充填法回收选矿车间下预留保安矿柱;无底柱分段崩落法开采保安矿柱以外的其他矿体。为了研究联合开采时回采顺序对地表稳定性的影响,采用数值模拟方法得到不同回采顺序下地表监测点的垂直位移,确定地表沉降最小且施工组织容易的回采顺序组合为最优方案,即充填法采用"中-左-右"以及无底柱分段崩落法采用"左-右-中"的回采顺序。模拟开采结果表明,在该回采顺序方案下,选矿车间区域的地表稳定性、充填采场及隔离矿柱的安全性均满足要求。     

UHF、L双频段频率发生器

已设计和研制成ＵＨＦ,Ｌ双频段频率发生器,通过控制电压可方便地在同一输出口输出所需信号,由于使用继电器和单刀双掷射频开关同步控制两个频段ＶＣＯ的工作与否及两通道的接通与否,使两频段的隔离度大于５０ｄＢ,采用温控装置使ＶＣＯ处于恒温工作状态,使输出频率稳定度大于１０＾－５,作者还介绍了该频率发生器的工作原理及主要部件的设计方法,最后给出了测试结果。     

2017年至2019年海北州植被覆盖度时空动态变化分析研究

本文旨在对2017年至2019年海北州的植被覆盖度变化进行分析,获得其相关的时空变化规律。基于2017年至2019年生长季多时相的GF-1 WFV遥感影像,提取植被覆盖度。为了分析不同覆盖度等级的植被的时空变化,本文将植被覆盖度分为全植被、高植被、中植被、低植被和无植被五个不同等级,并在每个等级内结合DEM数据进一步划分为高山、中山、低山进行分析。研究结果表明：(1)对于植被空间分布特点而言,相对于全植被、高植被、中植被和低植被,无植被的面积占比比较少;(2)在空间分布上,针对不同的海拔高度而言,中山区的植被覆盖度较高,低山区次之,高山区的植被覆盖度最少;(3)从年际变化的角度来看,试验区在2017至2018年和2018至2019年期间,均会出现全植被和高植被相互转化的趋势;(4)从同一年度的生长季的分析发现,试验区内的植被覆盖度在6月至8月呈现上升趋势,在8月至9月呈现下降趋势,相对于其他等级,全植被的变化更加符合该趋势。通过本研究,可为掌握海北州植被覆盖度的时空动态变化规律提供支持。