Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells

Effects of La³⁺ and Gd³⁺ on Ca²⁺ influx were investigated in rat hepatoma H-35 cells by measuring the initial rate of⁴⁵Ca²⁺ uptake. It was found that the maximum initial rate of Ca²⁺ uptake was increased six-to ten-fold at low concentrations of La³⁺ and Gd³⁺. Kinetic analyses by measuring the initial rate of Ca²⁺ influx at different external Ca²⁺ concentrations indicated the existence of two intracellular exchangeable components in the basal Ca²⁺ system, with low and high affinities for Ca²⁺, and only one class of Ca²⁺ binding sites was observed in the La³⁺-or Gd³⁺-treated cells. For high affinity, La³⁺ and Gd³⁺ increased both kinetic parametersK _m andV _max of basai Ca²⁺ influx. La³⁺ and Gd³⁺ compete directly with Ca²⁺ for Ca²⁺ binding site for low affinity. The kinetics is competitive.     

表面粗糙度的激光在线测量

为了克服现有方法在表面粗糙度测量范围和抗震动等方面的不足,分析了最近发展起来的几种动态表面粗糙度测量方法的优缺点,提出采用被测表面激光反射图的暗区比来实现运动表面粗糙度的实时测量。该方法的测量范围可达３０倍跨度,即可测量的表面粗糙度为０．０５μｍ到１．６μｍ或０．４μｍ到１２．５μｍ。分析了试样的运动速度和初试平均光强对暗区比的影响,该方法的测量结果与Ｔｅｌｙｅｒ－ｓｏｆｔ表面形貌测量仪的测量结果很吻合。     

Degenerating Families of Dendrograms

Dendrograms used in data analysis are ultrametric spaces, hence objects of nonarchimedean geometry. It is known that there exist p-adic representations of dendrograms. Completed by a point at infinity, they can be viewed as subtrees of the Bruhat-Tits tree associated to the p-adic projective line. The implications are that certain moduli spaces known in algebraic geometry are in fact p-adic parameter spaces of dendrograms, and stochastic classification can also be handled within this framework. At the end, we calculate the topology of the hidden part of a dendrogram.     

沟通语音与沟通风格对决策者接受建议的影响

 人机系统中广泛采用计算机合成语音为决策者提供建议。为了比较合成语音与自然语音以及直接和含蓄的沟通风格对不同国家决策者的影响,通过实验的方法,招募了24位中国学生和24位德国学生参与决策实验,测量决策者对建议的接受度,自信水平的改变度,感知的影响,以及对建议者的信任度、满意度和未来合作意向。统计分析结果显示,相比自然语音,合成语音建议显著提高决策者的自信水平,但是决策者对合成语音建议感知的影响较弱且未来合作意向较低。总体来看,直接的沟通风格比含蓄的沟通风格更容易被决策者接受并获得决策者更高的评价。当采用直接的沟通风格时,德国决策者比中国决策者感知到更强的影响;当采用含蓄的沟通风格时,中国决策者比德国决策者对建议的接受度更高。研究结果为合成语音软件的设计提供了指导。     

一种基于IP技术的PBX系统

给出了一种基于IP技术的PBX系统的总体方案,重点介绍了呼 管理嚣数据库、用户接口界面、呼叫管理控制和语音信箱的设计和研制,最后给出了测试和实验结果。该PBX系统成成功地实现了南京和香港之间的语音通信。     

Causation and gravitation in George Cheyne's Newtonian natural philosophy

This paper analyzes the metaphysical system developed in Cheyne’s Philosophical Principles of Religion. Cheyne was an early proponent of Newtonianism and tackled several philosophical questions raised by Newton’s work. The most pressing of these concerned the causal origin of gravitational attraction. Cheyne rejected the occasionalist explanations offered by several of his contemporaries in favor of a model on which God delegated special causal powers to bodies. Additionally, he developed an innovative approach to divine conservation. This allowed him to argue that Newton’s findings provided evidence for God’s existence and providence without the need for continuous divine intervention in the universe.     

Construction of one-Lee weight and two-Lee weight codes over F<Subscript><Emphasis Type="Italic">p</Emphasis></Subscript> + <Emphasis Type="Italic">v</Emphasis>F<Subscript><Emphasis Type="Italic">p</Emphasis></Subscript>

This paper is devoted to the construction of one-Lee weight codes and two-Lee weight codes over F _p + vF _p (v ² = v) with type \({p^{2{k_1}}}{p^{{k_2}}}{p^{{k_3}}}\) based on two different distance-preserving Gray maps from ((F _p + vF _p ) ⁿ , Lee weight) to (F _p ²ⁿ , Hamming weight), where p is a prime. Moreover, the authors prove that the obtained two-Lee weight codes are projective only when p = 2.     

Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy

In addition to its activity in nicotinamide adenine dinucleotide (NAD(+)) synthesis, the nuclear nicotinamide mononucleotide adenyltransferase NMNAT1 acts as a chaperone that protects against neuronal activity-induced degeneration. Here we report that compound heterozygous and homozygous NMNAT1 mutations cause severe neonatal neurodegeneration of the central retina and early-onset optic atrophy in 22 unrelated individuals. Their clinical presentation is consistent with Leber congenital amaurosis and suggests that the mutations affect neuroprotection of photoreceptor cells.