Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis

When they recognize a target cell, natural killer (NK) cells mount an attack to kill the target by exerting their cytotoxicity via the exocytosis of cytotoxic granules. Although the details of this process (which includes the movement of cytotoxic granules in the immune synapse and their fusion with the plasma membrane, releasing granzymes and perforin into the synaptic cleft) are relatively better understood, the post-exocytosis regulation of the process is still largely unknown. Here we show that a clathrin-dependent endocytosis stimulated by target cell occurs in NK92 cell line, which is closely correlated with granzyme B recovery. Inhibition of the endocytosis significantly attenuates the cytotoxicity of NK92 cells. The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells.     

等精度测频仪的低成本微控制器实现

在叙述等精度测频原理及误差分析的基础上,阐述低成本微控制器(MCU)的硬件设计和软件设计,用低成本MCU实现的等精度测频仪的精度高,成本低,可靠性高,使用方便,具有实用价值和生产意义.     

m-半格中的滤子及其相关拓扑性质

首先, 通过在m-半格中引入滤子的概念, 讨论m-半格中滤子的若干性质, 进而构造m-半格上的滤子拓扑, 得到了滤子空间的一系列性质; 其次, 证明每个滤子空间是连通的, 且双侧m-半格上的滤子空间满足第一可数性公理, 并分别给出其为T₀空间及满足第二可数性公理的充要条件; 最后, 通过引入m-半格中素滤子的概念, 讨论m-半格上的对偶素谱空间, 证明双侧m-半格上的对偶素谱空间是T₀空间, 并给出其为T₁空间的等价刻画.     

Multi-objective carrier chaotic evolutionary algorithm for DNA sequences design

DNA computing is a new vista of computation, which is of biochemical type. Since each piece of information is encoded in biological sequences, their design is crucial for successful DNA computation. DNA sequence design is involved with a number of design criteria, which is difficult to be solved by the traditional optimization methods. In this paper, the multi-objective carrier chaotic evolution algorithm (MCCEA) is introduced to solve the DNA sequence design problem. By merging the chaotic search base on power function carrier, a set of good DNA sequences are generated. Furthermore, the simulation results show the efficiency of our method.     

磁流变半主动悬架加速度驱动阻尼控制策略仿真分析

加速度驱动阻尼(Acceleration Driven Damper, ADD)控制策略原理简单、易于工程化应用,但其阻尼系数的选择对控制效果有重要的影响。基于理想ADD控制悬架系统模型,分析不同阻尼系数对悬架响应的影响;建立悬架系统综合性能目标函数,仿真得到理想ADD控制策略最优阻尼系数。基于磁流变半主动悬架系统仿真模型,进行ADD控制策略阶跃和随机路面激励仿真。仿真结果表明,在随机激励下,车身加速度可以降低11.83%,但会恶化轮胎动载荷及悬架动挠度指标,使得轮胎动载荷和悬架动挠度分别增加7.98%和15.45%;与被动悬架系统相比,ADD控制磁流变半主动悬架对较高频激振下的车身加速度有较好的抑制作用;同时,ADD控制算法在车身加速度过零时,阻尼力高频切换会引起颤振现象。     

平面上的一类随机积分微分方程解的轨道唯一性

本文考虑平面上的随机积分微分方程:(Ⅰ) 在具有积分压缩函数的条件下解的轨道唯一性。     

车辆变速轨迹跟踪横纵耦合控制方法

针对变化速度下车辆轨迹跟踪精度以及实时性差的问题,提出一种基于模型预测控制的横纵耦合控制方法。在三自由度车辆动力学模型中,将车轮驱动力与前轮转角作为控制量,以单控制器形式实现车辆横纵向运动的综合控制,并且在考虑耦合特性的基础上,设计目标函数与可变权重系数,求解最优横纵向控制量。并且基于五次多项式理论,设计一种变速双移线轨迹以验证控制器综合轨迹跟踪能力。实验结果表明,该控制器能有效跟踪变化车速并且保持高轨迹跟踪精度与良好的实时性。     

聚苯胺/涤纶导电复合纤维的制备

先将涤纶纤维在苯胺溶液中预浸泡,然后进行处理,再将纤维置于氧化剂的酸溶液中使苯胺在纤维上氧化聚合,同时进行掺杂制得聚苯胺/涤纶导电复合纤维。讨论了苯胺单体含量、掺杂酸浓度、氧化剂浓度、反应温度及时间对纤维导电性能的影响。实验表明,采用此法制得的导电纤维具有较高的聚苯胺含量和优良的导电性能,电导率达10~(-2)S/cm数量级。