Ipr1 gene mediates innate immunity to tuberculosis

An estimated eight million people are infected each year with the pathogen Mycobacterium tuberculosis, and more than two million die annually. Yet only about 10% of those infected develop tuberculosis. Genetic variation within host populations is known to be significant in humans and animals, but the nature of genetic control of host resistance to tuberculosis remains poorly understood. Previously we mapped a new genetic locus on mouse chromosome 1, designated sst1 (for supersusceptibility to tuberculosis 1). Here we show that this locus mediates innate immunity in sst1 congenic mouse strains and identify a candidate gene, Intracellular pathogen resistance 1 (Ipr1), within the sst1 locus. The Ipr1 gene is upregulated in the sst1 resistant macrophages after activation and infection, but it is not expressed in the sst1 susceptible macrophages. Expression of the Ipr1 transgene in the sst1 susceptible macrophages limits the multiplication not only of M. tuberculosis but also of Listeria monocytogenes and switches a cell death pathway of the infected macrophages from necrosis to apoptosis. Our data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis.     

单片机在弯管自动化生产线中的应用

本文重点介绍弯管自动化生产线单片机自动控制系统组成及软件实现方法。     

两区域系统实时校正累积偶然交换功率研究

本文就基本的两区域互联电力系统联络线偏差控制中的系统累积时间误差和联络线偶然交换功率积累问题进行了分析。在叙述基本表达式的基础上，针对产生偶然交换功率积累偏差的原因，提出一种以实时方式校正累积偶然交换功率，同时又减少系统累积时间误差的方案。最后就这一方案的应用进行了讨论。     

离散数据的信息聚类

采用信息聚类分析方法，对柏拉图的几部著作进行了科学的分类。排出了其出版时间的先后顺序，得出了较客观的结论。此方法对一般离散数据的处理也能作出较好的结果。     

Theoretical calculations on the atomic and electronic structure of β-SiC(110) surface

We present a theoretical calculation of the atomic and electronic structure of β-SiC and its non-polar (110) surface using the full potential linear augmented plane wave (FPLAPW) approach. The calculated lattice constant and bulk modulus of β-SiC crystal are in excellent agreement with experimental data. The atomic and electronic structure of β-SiC(110) surface has been calculated by employing the slab and supercell model. It is found that the surface is characterized by a top-layer bond-length-contracting rotation relaxation in which the Si-surface atom moves closer towards the substrate while the C-surface atom moves outward. This relaxation is analogous to that of Ⅲ-Ⅴ semi-conductor surface. The driving mechanism for this atomic rearrangement is that the Si atom tends to a planar sp2-like bonding situation with its three N neighbors and the N atom tends to a p3-like bonding with its three Si neighbors. Furthermore, surface relaxation induces the change from metallic to semiconducting characterization.     

美国决策支持系统开发现状

本文介绍了决策支持系统(DSS)在美国的应用,DSS的分析与设计方法以及DSS的开发策略;介绍了一种新型的满足高级行政管理人员需求的管理支持系统——执行信息系统EIS(Executive Information System)。     

基于深度学习的心血管血流动力学参数反演

考虑现有血流动力学参数反演方法在实际应用中存在计算量大、迭代易发散等问题,提出一种新的基于深度学习的心血管血流动力学参数反演方法.首先建立一维-零维耦合的多尺度血流动力学模型;随后基于卷积神经网络和全连接神经网络提出一种用于参数反演的混合多源输入深度网络模型;针对测量波形中的噪声干扰问题,提出一种同时利用多个深度网络的...     

高碳海绵铁电化学絮凝处理铅锌冶炼厂制酸废水

 采用高碳海绵铁(含13.00% C,55.40% Fe)电化学-絮凝处理铅锌冶炼制酸废水,研究了pH和时间、海绵铁用量和粒径等反应条件对废水中铅和锌离子的去除效果及影响.结果表明:在废水初始pH=3.0,海绵铁用量为30 g/L和粒径<0.301 mm,反应时间为40 min的条件下,废水中的铅锌离子去除效果最佳,电化学处理去除率分别为98.87%和77.89%,废水中的铜、总镉和总砷等离子去除率分别为93.50%、91.50%和47.26%;采用电化学-絮凝耦合处理,在最佳条件下,铅锌的去除率分别达到99.90%和99.67%,同时总砷、总镉和铜离子等得到进一步去除,去除率分别为97.77%、99.56%和97.77%,废水可达到《污水综合排放标准》(GB 8978—1996)中一级标准要求.     

面向钢铁制造流程的合同计划组合优化

从钢厂整体流程的层次上研究了合同计划优化问题.首先在分析某钢厂生产流程特点的基础上讨论了铁钢界面、精炼设备和铸轧界面的生产组织,研究了铁水供求节奏的协调.提出了表征铁钢界面铁水供求节奏协调程度的δ因子,并讨论了δ不同取值范围与铁水包备包和等待数目的关系.之后,建立了面向钢铁制造流程的合同计划优化数学模型,并采用禁忌搜索算法对模型进行求解.最后,从钢厂中随机选取3组不同规模的实际生产合同,并对其进行合同计划优化仿真实验.实验结果表明,所建立的合同计划优化模型和求解算法能够较好地解决面向钢铁制造流程的合同计划优化问题.