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51.
52.
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials 总被引:7,自引:0,他引:7
A H Sinclair J W Foster J A Spencer D C Page M Palmer P N Goodfellow J A Graves 《Nature》1988,336(6201):780-783
Sexual differentiation in placental mammals results from the action of a testis-determining gene encoded by the Y chromosome. This gene causes the indifferent gonad to develop as a testis, thereby initiating a hormonal cascade which produces a male phenotype. Recently, a candidate for the testis-determining gene (ZFY, Y-borne zinc-finger protein) has been cloned. The ZFY probe detects a male-specific (Y-linked) sequence in DNA from a range of eutherian mammals, as well as an X-linked sequence (ZFX) which maps to the human X chromosome. In marsupials it is also the Y chromosome that seems to determine the fate of the gonad, but not all sexual dimorphisms. Using the ZFY probe we find, surprisingly, that the ZFY homologous sequences are not on either the X or the Y chromosome in marsupials, but map to the autosomes. This implies ZFY is not the primary sex-determining gene in marsupials. Either the genetic pathways of sex determination in marsupials and eutherians differ, or they are identical and ZFY is not the primary signal in human sex determination. 相似文献
53.
Frederick G. Page 《Annals of science》2013,70(2):185-200
This essay describes the background and possible reasons for legal intervention in the use of lime in the early bleaching industry and draws on the Statutes at Large and other Acts of Parliament as primary sources. The developing chemical knowledge that may have contributed to the later Acts of repeal is also considered in some detail. The earliest noted prohibition was in 1633 and the years 1823, 1825, and 1828 were important repeal dates. No related legislation later than 1828 has been found. During the period from 1633 to 1828 there were many renewals and modifications to existing laws concerning linen and hempen manufacture; several of these contained subsections regarding bleaching. The considerable number of such Acts may account for the apparent confusion shown by earlier authors on this subject. Furthermore, the various Acts passed by the Irish House of Commons over its lifetime from 1400 to 1800, with its many interruptions, were published in a limited number of editions and are consequently held by few libraries. Ireland instituted its own laws and it was only after the Act of Union in 1800 that matters were dealt with by Westminster. Indeed, earlier historians have not always appreciated that, at certain periods of the history of the United Kingdom, Ireland and Scotland (as well as England) had their own separate parliaments. 相似文献
54.
Megan Chircop Chandra S. Malladi Audrey T. Lian Scott L. Page Michael Zavortink Christopher P. Gordon Adam McCluskey Phillip J. Robinson 《Cellular and molecular life sciences : CMLS》2010,67(21):3725-3737
Successful completion of cytokinesis requires the spatio-temporal regulation of protein phosphorylation and the coordinated
activity of protein kinases and phosphatases. Many mitotic protein kinases are well characterized while mitotic phosphatases
are largely unknown. Here, we show that the Ca2+- and calmodulin-dependent phosphatase, calcineurin (CaN), is required for cytokinesis in mammalian cells, functioning specifically
at the abscission stage. CaN inhibitors induce multinucleation in HeLa cells and prolong the time cells spend connected via
an extended intracellular bridge. Upon Ca2+ influx during cytokinesis, CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II (dynII).
At the intracellular bridge, phospho-dynII and CaN are co-localized to dual flanking midbody rings (FMRs) that reside on either
side of the central midbody ring. CaN activity and disassembly of the FMRs coincide with abscission. Thus, CaN activity at
the midbody plays a key role in regulating the completion of cytokinesis in mammalian cells. 相似文献
55.
Herzberg RD Greenlees PT Butler PA Jones GD Venhart M Darby IG Eeckhaudt S Eskola K Grahn T Gray-Jones C Hessberger FP Jones P Julin R Juutinen S Ketelhut S Korten W Leino M Leppänen AP Moon S Nyman M Page RD Pakarinen J Pritchard A Rahkila P Sarén J Scholey C Steer A Sun Y Theisen Ch Uusitalo J 《Nature》2006,442(7105):896-899
A long-standing prediction of nuclear models is the emergence of a region of long-lived, or even stable, superheavy elements beyond the actinides. These nuclei owe their enhanced stability to closed shells in the structure of both protons and neutrons. However, theoretical approaches to date do not yield consistent predictions of the precise limits of the 'island of stability'; experimental studies are therefore crucial. The bulk of experimental effort so far has been focused on the direct creation of superheavy elements in heavy ion fusion reactions, leading to the production of elements up to proton number Z = 118 (refs 4, 5). Recently, it has become possible to make detailed spectroscopic studies of nuclei beyond fermium (Z = 100), with the aim of understanding the underlying single-particle structure of superheavy elements. Here we report such a study of the nobelium isotope 254No, with 102 protons and 152 neutrons--the heaviest nucleus studied in this manner to date. We find three excited structures, two of which are isomeric (metastable). One of these structures is firmly assigned to a two-proton excitation. These states are highly significant as their location is sensitive to single-particle levels above the gap in shell energies predicted at Z = 114, and thus provide a microscopic benchmark for nuclear models of the superheavy elements. 相似文献
56.
Andreyev AN Huyse M Van Duppen P Weissman L Ackermann D Gerl J Hessberger FP Hofmann S Kleinbohl A Munzenberg G Reshitko S Schlegel C Schaffner H Cagarda P Matos M Saro S Keenan A Moore C O'Leary CD Page RD Taylor M Kettunen H Leino M Lavrentiev A Wyss R Heyde K 《Nature》2000,405(6785):430-433
Understanding the fundamental excitations of many-fermion systems is of significant current interest. In atomic nuclei with even numbers of neutrons and protons, the low-lying excitation spectrum is generally formed by nucleon pair breaking and nuclear vibrations or rotations. However, for certain numbers of protons and neutrons, a subtle rearrangement of only a few nucleons among the orbitals at the Fermi surface can result in a different elementary mode: a macroscopic shape change. The first experimental evidence for this phenomenon came from the observation of shape coexistence in 16O (ref. 4). Other unexpected examples came with the discovery of fission isomers and super-deformed nuclei. Here we find experimentally that the lowest three states in the energy spectrum of the neutron deficient nucleus 186Pb are spherical, oblate and prolate. The states are populated by the alpha-decay of a parent nucleus; to identify them, we combine knowledge of the particular features of this decay with sensitive measurement techniques (a highly efficient velocity filters with strong background reduction, and an extremely selective recoil-alpha-electron coincidence tagging methods). The existence of this apparently unique shape triplet is permitted only by the specific conditions that are met around this particular nucleus. 相似文献
57.
58.
Tagliaferri G Goad M Chincarini G Moretti A Campana S Burrows DN Perri M Barthelmy SD Gehrels N Krimm H Sakamoto T Kumar P Mészáros PI Kobayashi S Zhang B Angelini L Banat P Beardmore AP Capalbi M Covino S Cusumano G Giommi P Godet O Hill JE Kennea JA Mangano V Morris DC Nousek JA O'Brien PT Osborne JP Pagani C Page KL Romano P Stella L Wells A 《Nature》2005,436(7053):985-988
'Long' gamma-ray bursts (GRBs) are commonly accepted to originate in the explosion of particularly massive stars, which give rise to highly relativistic jets. Inhomogeneities in the expanding flow result in internal shock waves that are believed to produce the gamma-rays we see. As the jet travels further outward into the surrounding circumstellar medium, 'external' shocks create the afterglow emission seen in the X-ray, optical and radio bands. Here we report observations of the early phases of the X-ray emission of five GRBs. Their X-ray light curves are characterised by a surprisingly rapid fall-off for the first few hundred seconds, followed by a less rapid decline lasting several hours. This steep decline, together with detailed spectral properties of two particular bursts, shows that violent shock interactions take place in the early jet outflows. 相似文献
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