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121.
F. V. DeFeudis L. M. Orensanz Muñoz M. A. Vidal G. Corrochano M. Sanchez del Alamo 《Cellular and molecular life sciences : CMLS》1978,34(9):1169-1170
Summary High-affinity, Na+-independent binding of -alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other -amino acids, but not by taurine or GABA. This binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both -alanine and glycine.This study was supported in part by Centro Ramón y Cajal and Fundacion Juan March. 相似文献
122.
T. T. Yen J. A. Allan D. V. Pearson J. M. Acton 《Cellular and molecular life sciences : CMLS》1978,34(12):1542-1543
Summary Treating VY/WfL-A
vy
/a mice with 5-androstan-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and controlA
vy
/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5-androstan-17-one inA
vy
/a mice was reversible upon withdrawal of treatment.The authors wish to thank Mr W.R. Gibson and Drs C.G. Culbertson and P.N. Harris for performing the pathological examinations. 相似文献
123.
M. Tardy B. Rolland J. Bardakdjian P. Gonnard 《Cellular and molecular life sciences : CMLS》1978,34(9):1137-1138
Summary -(4-chlorophenyl)-GABA, a GABA mimetic compound, acts as an inhibitor of GABA metabolism in both synaptosomal and extrasynaptosomal compartments. It has no significant action on GABA or Glu uptake by synaptosomes. 相似文献
124.
N. Michajlovskij V. Štrbák O. Földes 《Cellular and molecular life sciences : CMLS》1978,34(3):409-410
Summary The administration of thiocyanate to rats caused a significant increase of serum free thyroxine fraction, which coincided with the significant decrease of TSH level. The other components (AFT4, T4, T3) in serum at this time were decreased or unchanged. The finding suggests the role of free thyroxine fraction in feed-back regulation of TSH secretion.Acknowledgment. We thank Dr A. Parlow and the NIAMDD, Rat Pituitary Hormone Distribution Program, for material for rat TSH immunoassay; Dr J. Nauman (Inst. Postgrad. Med., Warsaw, Poland) for T3 antibody, and to Ing. J. Sadlo, Mrs M. t'astná and Miss R Fajkoová for technical assistance. 相似文献
125.
P. Gandhi 《Cellular and molecular life sciences : CMLS》1978,34(1):15-15
Summary Incubation of 5,5-7,7-tetramethoxy-8,8-biflavone withAspergillus niger results in the formation of 4,4-dihydroxy-5,5-7,7-tetramethoxy-8,8-biflavan.Part of this work was done at Allahabad University, Chemical Laboratories. 相似文献
126.
Summary
2O,6N-butyryl, 3, 5-cyclic monophosphate (dibu cAMP) when added to fetal rat heart cells in culture inhibits myocyte contraction. This inhibition is 100, 84 and 51% complete when the dibu cAMP concentration used is 2, 0.2 and 0.02 mM, respectively. The potency of dibu cAMP derivatives in myocyte contraction inhibition follows the order, dibu cAMP>
6N-bu cAMP>
2O-bu cAMP=AMP>butyrate. The inhibition caused by the first three chemicals is greater than 70%.The author was a Moss Heart Fellow and acknowledges the technical assistance of Ms Martha Peet. This work was supported in part by the American Heart Association, National Science Foundation and American Cancer Society. 相似文献
127.
Summary The seedling growth ofBrassica campestris var.varuna, has been studied, as affected by water-stress and gibberellin treatments. A boost in the net GA response due to water-stress, has been observed. Thus presence of GA can overcome the water-stress effects.Publication No. 26 from Dept of Biosciences, Himachal Pradesh University, Simla. Authors are grateful to CSIR, New Delhi, for JRF to SB. 相似文献
128.
Summary The effects of L-glutamic acid and of some glutamate analogues have been studied on the central nervous system of the snailHeobania vermiculata, using conventional electrophysiological techniques. The glutamate H-response had the mean equilibrium value of-(57±4) mV and was associated with a Cl– conductance change. The D-response to glutamate application showed an involvement of sodium ions. Aspartate was agonist of glutamate action and displayed similar equilibrium value of the H-response, whereas quisqualate H-response was non-invertible.The authors wish to express their thanks to Prof. A. Curatolo for his continual interest and advice, and to Dr J. Stinnakre for the criticism of the text. 相似文献
129.
Summary The effects of time and various doses of testosterone on the responsiveness of lactate dehydrogenase of pituitary of 7-, 38- and 78-week-old rats were studied. The activity of the enzyme increases in 78-week-old rats. Castration decreases the enzyme activity at all ages. Maximum increase in the enzyme activity is seen with 50 and 100 g of testosterone 4 h after administration of hormone to castrated rats. No further time and dose-dependent effect is observed. The magnitude of increase for the enzyme is higher at the age of 38 weeks and decreases in 78-week-old rats.To whom all correspondence should be addressed. The authors are grateful to Professor M.S. Kanungo, Biochemistry Laboratory, Department of Zoology, Banaras Hindu University for the suggestions and encouragement. K.V.G. thanks the PL-480 for a research fellowship. 相似文献
130.
J P Debeaupuis P Lafont 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,286(5):431-434
A strain of Aspergillus fumigatus Fres., isolated from sugar-beet draffs, synthesizes in vitro four toxic metabolites which have not yet been described in these fungal species. Toxic effects of the most abundant of these metabolites "fumitoxin A" have been studed on chick embryo. Artemia salina larvae, cell cultures, and on mice. 相似文献