黄酮类化合物清除对苯半醌负离子自由基研究(Ⅰ)

以对苯半醌负离子自由基为模型 ,利用ESR技术研究黄酮类化合物清除自由基的作用 ,初步获得一些构效关系。     

Determination of the Altyn Tagh strike-slip fault basin and its relationship with mountains

A special extended basin topography is developed in the middle segment of the Altyn Tagh Fault Zone. The ratio of its length to width is over 50. The long boundaries at the two sides of the basin are controlled by the straight normal faults with strike-slip component. Within the basin, the Cenozoic strata are spread. The Altyn Tagh main fault goes through the basin, and a series of strike-slip topography was formed within the basin. The reverse thrust structures were formed at the two sides of the center of the basin, thus making the geological bodies composed of old metamorphic rocks at the two sides of the basin extrude vertically，and forming the extended massif (mountain) at the sides of the basin and parallel to the basin. This special topography was called the strike-slip fault basin. The giant extended strike-slip fault basin began to form during Pliocene, and its topography was basically formed during the late Pleistocene. It is the special topography formed during the strike-slip deformation process of the Altyn Tagh Fault Zone and under both transpression and uplifting.     

Summertime Subtropical Countercurrent on isopycnals in the western North Pacific

Circulations on isopycnals (σrθ) in the western North Pacific were investigated by using P-vector method;the data were taken from the U.S. Navy's climatological temperature and salinity dataset (public domain) with 1/2°×1/2° resolution. Results not only show the main circulation systems on isopycnals in the western North Pacific such as the North Equatorial Current (NEC), Kuroshio and Kuroshio Countercurrent, but also reveal the Subtropical Countercurrent (STCC) clearly. In this note we pay attention to discussing the distribution of STCC in summer (in June).The STCC flows eastward along a winding road; on shallow isopycnals, the STCC originates from the area east of Bashi Strait at about 122.5°E; with the isopycnals increasing, the origin and flow core of STCC move to north and east, but the main part of STCC is still between 18° and 23.5°N, i.e.near the Tropic of Cancer. There exists STCC on all isopycnals between the sea surface and 25.8 σθThe current vectors of STCC on isopycnais are shown for the first time, and the distribution of the potential vorticity indicates that STCC is just overlying the southern boundary of the Subtropical Mode Water (STMW).``     

关于局部分次Morita对偶

证明了一些gr－线性紧模的性质，刻划了gr－内射，gr－线性紧和gr－反射之间的关系。同时给出了局部分次Morrita对偶的刻划， 推广了C.Menini和A.D.Rio 的一个主要结果。     

随机多址访问协议中最优帧模式的混合遗传算法

在随机接入协议中 ,竞争时隙与预约时隙在一帧中的相对位置 (帧模式 )对系统的吞吐量有很大的影响 .利用混合遗传算法搜索出不同业务量下的最优帧模式 ,提高了系统的吞吐量 .     

Sox9 induces testis development in XX transgenic mice.

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.     

Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12).

Retinitis pigmentosa (RP) comprises a clinically and genetically heterogeneous group of diseases that afflicts approximately 1.5 million people worldwide. Affected individuals suffer from a progressive degeneration of the photoreceptors, eventually resulting in severe visual impairment. To isolate candidate genes for chorioretinal diseases, we cloned cDNAs specifically or preferentially expressed in the human retina and the retinal pigment epithelium (RPE) through a novel suppression subtractive hybridization (SSH) method. One of these cDNAs (RET3C11) mapped to chromosome 1q31-q32.1, a region harbouring a gene involved in a severe form of autosomal recessive RP characterized by a typical preservation of the para-arteriolar RPE (RP12; ref. 3). The full-length cDNA encodes an extracellular protein with 19 EGF-like domains, 3 laminin A G-like domains and a C-type lectin domain. This protein is homologous to the Drosophila melanogaster protein crumbs (CRB), and denoted CRB1 (crumbs homologue 1). In ten unrelated RP patients with preserved para-arteriolar RPE, we identified a homozygous AluY insertion disrupting the ORF, five homozygous missense mutations and four compound heterozygous mutations in CRB1. The similarity to CRB suggests a role for CRB1 in cell-cell interaction and possibly in the maintenance of cell polarity in the retina. The distinct RPE abnormalities observed in RP12 patients suggest that CRB1 mutations trigger a novel mechanism of photoreceptor degeneration.     

Gastrointestinal transit and digestibility of maltitol,sucrose and sorbitol in rats: A multicompartmental model and recovery study

Using data obtained with a dye marker and the gavage technique, the kinetics of gastrointestinal transit of different loads of sugar substitutes (maltitol, sorbitol) and sugar (sucrose) in the rat were analysed using a linear multicompartmental model over a range from the realistic to the non-physiologic high, of carbohydrate intake levels and using only a few experimental time points. The model gave detailed insight into intestinal propulsion and gastrocecal transit time. Rate constants of transport between the compartments investigated were determined; they showed characteristics which could be related to the substance and the dosage administered. Analyses of the gastrointestinal content and calculations of the intestinal net water movement showed that the digestibility and absorption of the disaccharide sugar alcohol, maltitol, in the small gut depended inversely on the dose ingested. For all substances tested, caloric availability in the small intestine was calculated. At a physiological low level of maltitol intake, the results also indicated an insignificant calorie-saving effect in comparison to sucrose, an effect based mainly on the slow absorption rate of the maltitol cleavage product sorbitol.     

Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity

The adenylate cyclase activator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin were found to inhibit in a dose-dependent fashion the ecdysone 20-monooxygenase activity associated with wandering stage larvae ofDrosophila melanogaster and fat body and midgut from last instar larvae of the tobacco hornworm,Manduca sexta. The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5×10^–6 to 5×10^–4 M.