15MnMoVNRe钢焊接近缝区拘束应变—相变—韧性之间的关系

以不同焊接热循环分别联合不同拘束应变循环两模拟试验结果,证明在同一热循环作用下,随着拘束应变量的增大使15MnMoVNRe钢CCT图中的B_?和M_?点逐次向左上方移动,从而对其显微组织和其精细结构发生了显著的作用,导致其韧性各异。当有该应变存在时所获得的韧性均高于无拘束应变的,并且该应变ε_max为1%时韧性最高。     

Miniaturized volume holographic optical data storage and correlation system with a storage density of 10 Gb／cm^3

The general idea of holographic optical data storage (HODS) is briefly introduced. Based on the recent advances of HODS, the key techniques and the challenges of HODS are discussed. Some new techniques are proposed to improve the system. A miniaturized volume holographic data storage and correlation system is presented. It can achieve a density of 10 Gb/cm^3 and a fast correlation recognition rate of more than 2000 images per second. It shows the attracting potential advantages over other conventional storage methods in the information storage as well as information processing.     

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Here we show that aurora kinase A phosphorylates p53 at Ser315, leading to its ubiquitination by Mdm2 and proteolysis. p53 is not degraded in the presence of inactive aurora kinase A or ubiquitination-defective Mdm2. Destabilization of p53 by aurora kinase A is abrogated in the presence of mutant Mdm2 that is unable to bind p53 and after repression of Mdm2 by RNA interference. Silencing of aurora kinase A results in less phosphorylation of p53 at Ser315, greater stability of p53 and cell-cycle arrest at G2-M. Cells depleted of aurora kinase A are more sensitive to cisplatin-induced apoptosis, and elevated expression of aurora kinase A abolishes this response. In a sample of bladder tumors with wild-type p53, elevated expression of aurora kinase A was correlated with low p53 concentration. We conclude that aurora kinase A is a key regulatory component of the p53 pathway and that overexpression of aurora kinase A leads to increased degradation of p53, causing downregulation of checkpoint-response pathways and facilitating oncogenic transformation of cells.     

Restriction enzyme-generated siRNA (REGS) vectors and libraries

Small interfering RNA (siRNA) technology facilitates the study of loss of gene function in mammalian cells and animal models, but generating multiple siRNA vectors using oligonucleotides is slow, inefficient and costly. Here we describe a new, enzyme-mediated method for generating numerous functional siRNA constructs from any gene of interest or pool of genes. To test our restriction enzyme-generated siRNA (REGS) system, we silenced a transgene and two endogenous genes and obtained the predicted phenotypes. REGS generated on average 34 unique siRNAs per kilobase of sequence. REGS enabled us to create enzymatically a complex siRNA library (>4 x 10(5) clones) from double-stranded cDNA encompassing known and unknown genes with 96% of the clones containing inserts of the appropriate size.     

Intersections of two offset parametric surfaces based on topology analysis

Conventional methods for solving intersections between two offset parametric surfaces often include iteratively using computationally expensive SSI (surface/surface intersections) algorithm. In addition, these methods ignore the relations between the intersection curves of parametric surfaces with different offset distances. The algorithm presented in this paper, makes full use of the topological relations between different intersection loops and calculates intersection loops with the help of previously calculated intersection loops. It first pre-processes two parametric surfaces to obtain the characteristic points, called topology transition points (TTPs), which can help in the subsequent finding of the topologies of the intersection curves. Then these points are categorized into several distinct groups, and we can determine the calculation strategy for searching initial points by analyzing the properties of these TTPs on the surfaces. Hence, all intersection curves can be marched from initial points by the tracing algorithm. The proposed algorithm could calculate intersection curves robustly and effectively, and has been tested to be capable of overcoming the degenerate conditions such as loop and singularities leaking that occur frequently in conventional algorithms.     

Distributed collaborative CAD system based on Web Service

This paper presents a novel Web Service based distributed collaborative CAD system employing feature as its collaborative design element and uses XML to define feature operations and communication protocol between the server and the client. To reduce network load and increase response ability of the system, the feature information is updated incrementally on the client. The system supports collaborative designing on heterogeneous platforms. Its framework and communication protocols are analyzed in detail. The experimental results from the developed prototype system showed that it can effectively support collaborative design under the distributed environment.     

Granuloma formation in rat liver after hepatic vein ligation

Summary After occlusion of the hepatic vein draining 1 lobe of the rat liver, macrophage granulomas develop which are reproducible and apparently related to a heat-labile macrophage mobilising factor.     

Grove Mountains （GRV）99027： A new Martian meteorite

We report the petrography, mineral chemistry and oxygen isotopic composition of GRV 99027, a new Martian meteorite recently collected during the 16th Chinese Antarctic Research Expedition. This meteorite consists of two textural regions. The interstitial region is characterized by the presence of plagioclase and phosphate, and higher FeO contents of olivine and orthopyroxene, in comparison with the poikilitic region. All of the observations are similar to the three known Martian lherzolites. We classify GRV 99027 as the fourth sample of Martian lherzolite.     

粘钢加固RC梁的锚固剪应力参数分析

在弹性理论的基础上,利用钢板固剪应力计算公式,对在集中荷载或均布荷载作用下采用粘钢加固的混凝土梁,风板锚固最大剪应力的有关影响因素。