Design and validation of wireless acceleration sensor network for structural health monitoring

0IntroductionCivil engineeringstructures suffer damages caused byenvironmental loads,fatigue,caustic effect and materialaging;thus,their strength reduces inevitably during theservice time.In order to assess these damages and makeappropriate decisions to keep the structures in good ser-vice,itis essential toimplement a damage detectionstrat-egy,and the process is referred to as structural healthmonitoring(SHM)[1].In an SHMsystem,a set of sen-sors are mountedinstructuresto measurethe structure…     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

The utility F-box for protein destruction

A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular activities. The abundance of a protein element is temporally and spatially regulated in two opposing aspects: de novo synthesis to manufacture the required amount of the protein, and destruction of the protein when it is in excess or no longer needed. One major route of protein destruction is coordinated by a set of conserved molecules, the F-box proteins, which promote ubiquitination in the ubiquitin-proteasome pathway. Here we discuss the functions of F-box proteins in several cellular scenarios including cell cycle progression, synapse formation, plant hormone responses, and the circadian clock. We particularly emphasize the mechanisms whereby F-box proteins recruit specific substrates and regulate their abundance in the context of SCF E3 ligases. For some exceptions, we also review how F-box proteins function through non-SCF mechanisms.     

基于提高学生创新素质的动物生理学实验教学模式改革

介绍了通过建立以实验为中心的教学改革,积极向学生开放实验室,使用现代化的教学仪器、观念、方法手段,考核制度多元化,采用案例式教学等措施,培养具有较宽厚的基础知识,较强的实际操作能力和处理、解决问题能力的高素质人才。     

某煤棚拱桁架结构动力特性及地震响应分析

文章采用数值分析方法,以单榀三心拱桁架为研究对象,分析了该结构在地震作用下的动力特性和动力响应,分析中考虑了不同地震波选取对结构动力响应的影响,可为相关设计和研究提供参考.     

普光气田地面集输系统的内腐蚀控制与监测

分析了高含H2S / CO2气田的腐蚀特征，探讨了在普光气田开发建设同期模拟普光集输工况开展的腐蚀性研究与成果；针对普光高含硫、复杂地形、人口密集、全湿气输送的地面集输系统，重点介绍了“抗硫碳钢＋缓蚀剂+清管+腐蚀监测”的综合腐蚀控制与监测设计方案，初步地总结和评价了投产运行后腐蚀控制与监测的实际实施效果，对存在的问题给出了建议。     

苏北经济发展的阶段、问题与对策分析

借鉴国外区域经济发展阶段的相关理论方法,通过人均GDP、产业结构、就业结构、工业结构和城市化水平等方面的综合比较,认为苏北整体发展已进入工业化中期阶段,正处于工业化的加速提升期和城市化的快速推进期;与此同时,苏北经济发展无论在规模、水平与结构,还是在质量与效益等方面,都面临着一系列亟待解决的问题;在此基础上,提出了壮大县域经济、优化产业结构、加快城乡一体化、完善基础设施和强化区域分工合作等促进苏北经济跨越发展的系列举措.     

从文学活动视角谈《少年维特之烦恼》的审美意义

文学作为人类一种特殊的高级的精神活动,具有鲜明的社会性.从文学活动的审美这一视角,剖析作者创作活动、读者阅读活动中的再创造、研究者从意识形态领域的发掘,力求通过特殊的审美观照进一步理解文学的本质意义.     

从专题报道看《城市画报》对“新生活”的建构

《城市画报》以“新生活的引领者”自居，其取得成功的主要原因是由于它对“新生活”这一概念的把握与理解，并使之建构的生活理念与生活方式成为城市人生活的引导。文章从最能反映杂志核心意义的专题报道入手，分析《城市画报》对作为“新生活”的都市生活文化的建构，并由此探讨“新生活”理念的未来发展方向。     

西宁地区青少儿骨龄评价

本文采用ＣＨＮ法对出生地为西宁地区的３０９５名７—１８岁汉族健康有少儿骨发育等级进行了评价，表明高原地区青少儿较同方法评定的平原青少儿骨发育成熟度明显延缓，这与测量身高、体重所得的结论一致并更加精确。本文建立的青海标准既是对全国标准的修正和补充、又是评价高原青少儿骨龄和发育水平等的重要依据。