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41.
在室内装潢方面,人们较注重室内布局和装饰,而对给水管道则极少关注.应引起足够的重视。在建筑给水系统中由新型塑料管材替代金属管材已成为趋势。所以,室内给水管应选用新型塑料管材,并且应根据新型塑料管材的特点进行施工。确保给水系统的安装质量。 相似文献
42.
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. 总被引:46,自引:0,他引:46
P Basset J P Bellocq C Wolf I Stoll P Hutin J M Limacher O L Podhajcer M P Chenard M C Rio P Chambon 《Nature》1990,348(6303):699-704
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies. 相似文献
43.
基于最大距离分割(MDS)码的码重分布,得到了不完全译码器中发生译码错误和译码失败的概率.根据译码错误和译码失败对MDS码误比特率的影响,推导出精确的误比特率公式.利用该公式可计算出不同长度的MDS码在加性白高斯噪声(AWGN)信道中的误比特率.仿真结果表明,该公式比传统的误比特率上限公式具有更高的精度. 相似文献
44.
LQ YingzhongInst. for Techno-Economics Energy System Analysis. P.O. Box Beijing China 《系统工程与电子技术(英文版)》1991,(1)
The long-term energy demand in China and the-Chinese share in global CO2 emission are forecasted on the basis of scenarios of population growth and economy development up to 2050 proposed in view of the interaction of energy, economy, environment and social development. The total energy demand in 2050 will reach 4.4~ 5.4 billion tce. It is shown in energy supply analysis that coal is China's major energy in primary energy supply. The share of CO2 emission in the future Chinese energy system will be out of proportion to its energy consumption share because of the high persentage of coal to be consumed. It will reach about 27%. The nuclear option which would replace 30.7% of coal in the total primary energy supply will reduce the share by 9.8%. So the policy considerations on the future Chinese energy system is of great importance to the global CO2 issues. 相似文献
45.
In this paper we extend Taub (1979) approach for prediction in the context of the variance components model. The extension obtained is based on the two‐way random‐effect model with heteroskedasticity. Prediction functions are then obtained in three heteroskedasticity cases (heteroskedasticity on the individual term , heteroskedasticity on the composite term ?it, and heteroskedasticity on the temporal term ). Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
46.
Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible
for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol
pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has
been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose
reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications.
Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to
explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of
previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently
available ones.
Received 4 December 2006; received after revision 12 February 2007; accepted 20 April 2007 相似文献
47.
Hellgren M Strömberg P Gallego O Martras S Farrés J Persson B Parés X Höög JO 《Cellular and molecular life sciences : CMLS》2007,64(4):498-505
The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2
(ADH2), an intriguing enzyme with apparently different functions in human and rodents. Kinetic constants were determined with
an HPLC method and a structural approach was implemented by in silico substrate dockings. For human ADH2, the determined Km values ranged from 0.05 to 0.3 μM and kcat values from 2.3 to 17.6 min−1, while the catalytic efficiency for 9-cis-retinol showed the highest value for any substrate. In contrast, poor activities
were detected for the rodent enzymes. A mouse ADH2 mutant (ADH2Pro47His) was studied that resembles the human ADH2 setup.
This mutation increased the retinoid activity up to 100-fold. The Km values of human ADH2 are the lowest among all known human retinol dehydrogenases, which clearly support a role in hepatic
retinol oxidation at physiological concentrations.
Received 12 October 2006; received after revision 6 December 2006; accepted 8 January 2007 相似文献
48.
Wang E Lenferink A O'Connor-McCourt M 《Cellular and molecular life sciences : CMLS》2007,64(14):1752-1762
Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a systems biology point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within networks. This approach shows that cancer genes often function as network hub proteins which are involved in many cellular processes and form focal nodes in information exchange between many signaling pathways. Literature mining allows constructing gene-gene networks, in which new cancer genes can be identified. The gene expression profiles of cancer cells are used for reconstructing gene regulatory networks. By doing so, genes which are involved in the regulation of cancer progression can be picked up from these networks, after which their functions can be further confirmed in the laboratory. 相似文献
49.
Lanigan F O'Connor D Martin F Gallagher WM 《Cellular and molecular life sciences : CMLS》2007,64(24):3159-3184
During its lifetime, the mammary gland undergoes many phases of development and differentiation. Much of this occurs during
puberty, when the ductal epithelium expands by branching morphogenesis, invading the surrounding fat pad to form an organised
mammary tree. Throughout its existence, the epithelium will go through several cycles of proliferation and cell death during
pregnancy, lactation and involution. Many of the signalling mechanisms which control the initial invasion of the fat pad by
the epithelium, and regulate its continuing plasticity, can be harnessed or corrupted by tumour cells in order to support
their aberrant growth and progression towards invasion. This is true not just for the epithelial cells themselves but also
for cells in the surrounding microenvironment, including fibroblasts, macrophages and adipocytes. This review examines the
complex web of signalling and adhesion interactions controlling branching morphogenesis, and how their alteration can promote
malignancy. Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review) 相似文献
50.
5-Methylcytosine localised in mammalian constitutive heterochromatin 总被引:26,自引:0,他引:26