Effect of prostaglandin E2 (PgE2) on the biosynthesis and metabolism of noradrenaline (NA) in the isolated and perfused rabbit heart]

In isolated perfused rabbit heart, Pg E2 at concentrations ranging from 1.10(-8) to 1.10(-4) M has shown no significant action either on the biosynthesis or on the metabolism of NA. But it inhibited NA uptake, nevertheless this action was weak.     

Metabolic activity of adipose tissue in the goat during gestation and at the beginning of lactation]

In 5 French Alpine goats, omental adipose tissue acetyl-CoA carboxylase, glucose-6-phosphate deshydrogenase, malic enzyme and lipoprotein lipase activities significantly decreased during the third month of gestation, whereas plasma non-esterified fatty acid and triacyglycerol contents increased. This probably reflects an early decreasing rate of adipose tissue anabolism during gestation in the Goat. At the third week of lactation, anabolic activities relative to DNA content of adipose tissue were extremely low, and the tissue weight relative to DNA was lower than during gestation. Metabolic alterations of omental adipose tissue in early lactation do not seem to be related to milk production level. These results could contribute to a better control of the kinetic of body lipid stores during the reproductive cycle in high milk yielding ruminants.