Asymptotic limits and stabilization for the 1D nonlinear Mindlin-Timoshenko system

<正> This paper shows how the so called von Karman model can be obtained as a singular limitof a modified Mindlin-Timoshenko system when the modulus of elasticity in shear k tends to infinity,provided a regularizing term through a fourth order dispersive operator is added.Introducing dampingmechanisms,the authors also show that the energy of solutions for this modified Mindlin-Timoshenkosystem decays exponentially,uniformly with respect to the parameter k.As k→∞,the authors obtainthe damped von Karman model with associated energy exponentially decaying to zero as well.     

Book Reviews: Behavior Change in the Human Services: An Introduction to Principles and Applications by Martin Sundel and Sandra S. Sundel. Exploring Personality: An Intellectual Odyssey by Russell L. Ackoff. The Ecologist: The Cosmic Covenant.

Systemic Practice and Action Research -     

Functional and physical communication between oncoproteins and tumor suppressors

The discovery of oncogenes (c-onc’s) and tumor suppressors (TS’s) has led to the concept that cancer arises from defects in each of these classes of genes or their products. More recently, it has been appreciated that c-onc and TS proteins often affect one another’s functions. Within this context, I review the two classical TS’s, p53 and the retinoblastoma protein, and the consequences of their inactivation. The various forms of genomic instability (GI) that underly the high mutation rates of transformed cells are then discussed. Particular emphasis is placed upon the concept that GI is not only an integral part of the transformed state but is a prerequisite. Increased oxidative DNA damage, and/or an inabiliy to repair it, can lead to GI. The review then discusses recent observations showing that loss of the TS protein peroxiredoxin 1 (prdx1) and increased expression of the c-onc protein c-Myc, each leads to increased oxidative DNA damage. The critical nature of the c-onc-TS interaction is underscored by that occurring between prdx1 and c-Myc, with the former protein regulating the production of DNA-damaging reactive oxygen species by the latter. The intimate association between these proteins and others serves as a paradigm for the exquisite balancing act that c-onc’s and TS’s must maintain in order to properly control normal DNA replication and cellular proliferation while simultaneously minimizing the acquisition of potentially neoplastic mutations. Received 10 May 2005; received after revision 3 July 2005; accepted 19 July 2005     

Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons

Many have hypothesized that cell death in Parkinsons disease is via apoptosis and, specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis using a mouse dopaminergic cell line of mesencephalic origin, MN9D, challenged with the Parkinsonism-causing neurotoxin MPP⁺ (1-methyl-4-phenylpyridinium ion). Apoptosis was the main mode of cell death when the cells were subjected to MPP⁺ treatment under serum-free conditions for 24 h. Caspase-3 and caspase-9, however, were not activated, thus indicating the existence of alternate or compensatory cell death pathway(s) in dopaminergic neuronal cells. Using caspase inhibitors, we demonstrated that these pathways involve caspase-2, –8, –6 and –7. A time-course study indicated that activation of caspase-2 and –8 occurred upstream of caspase-6 and caspase-7. Upon MPP⁺ challenge, the apoptosis-inducing factor was translocated from the mitochondria into the MN9D cytosol and nucleus. These results suggest the existence of alternative apoptotic pathways in dopaminergic neurons.Received 20 September 2004; received after revision 5 November 2004; accepted 22 November 2004     

第一条人类染色体序列正在完成拼接

当人类基因组计划向着在2000年3月前完成人类基因组30亿个碱基的一份草图的目标迈进时,三个测序小组正在到达一个不同的、也许更加有意义的里程碑：第一条人类染色体的完成图谱。在最近两周内,国际22号染色体测序协作组将宣布他们完成这项任务的好消息。与此同时,其他染色体的测序工作也将顺利地在2003年完成其测序的预定目标。参与协作的科学家分别来自：英国剑桥的桑格中心;美国诺曼州极克拉荷马大学;日本东京的庆应大学医学院。科学家们说他们的合作堪称国际学术合作的典范,“许多人为之抛洒了血汗和泪水。”尽管作为国际人类基因…     

网络广告竞价中的在线拍卖及其竞争策略

对网络广告位置拍卖的一种在线模型及其竞争策略进行了研究。建立了投标人数已知和未知的两种在线拍卖模型,并分别设计了竞争比为(2+1).(Φ+1-1)和2Φ-1的确定性在线策略,其中Φ为投标者对拍卖物品投标价上下界的比值。     

无功就地补偿技术在煤矿井下的应用前景

对无功就地补偿技术在煤矿供电系统的应用中进行了分析,指出该技术能够起到节约电能、提高供电质量、节约材料费等作用,阐述了无功就地补偿技术在煤矿供电系统中的应用有较好的发展前景。