Endogenously generated amyloid β increases membrane fluidity in neural 2a cells

The effect of endogenously generated amyloid β on membrane fluidity was investigated in Neural 2a cells stably expressing Swedish mutant amyloid precursor protein (APPswe). Membrane fluidity was studied by fluorescence polarizability using 1,6-Diphenyl-1,3,5-Hexatriene (DPH) as the fluorescence probe. It was found that the membrane fluidity in APPswe cells was significantly higher than that in its wild type counterparts. Alleviating the effect of amyloid β either by γ secretase activity inhibition or by amy...     

Simulations of seasonal variations of stable water isotopes in land surface process model CLM

In this study, we simulated and analyzed the monthly variations of stable water isotopes in different reservoirs at Manaus, Brazil, using the Community Land Model （CLM） that incorporates stable isotopic effects as a diagnostic tool for understanding stable water isotopic processes, filling the observational data gaps and predicting hydrometeorological processes. The simulation results show that the δ^18O values in precipitation, vapor and surface runoff have distinct seasonality with the marked negative correlations with corresponding water amount. Compared with the survey results by the International Atomic Energy Agency （IAEA） in co-operation with the World Meteorological Organization （WMO）, the simulations by CLM reveal the similar temporal distributions of the δ^18O in precipitation. Moreover, the simulated amount effect between monthly δ^18O and monthly precipitation amount, and MWL （meteoric water line） are all close to the measured values. However, the simulated seasonal difference in the δ^18O in precipitation is distinctly smaller than observed one, and the simulated temporal distribution of the δ^18O in precipitation displays the ideal bimodal seasonality rather than the observed single one. These mismatches are possibly related to the simulation capacity and the veracity in forcing data.     

线路病害整治措施探讨

文章针对线路路基轨道的病害,论述了当前快速化、重载化运输的条件下,根治翻浆冒泥病害的方法以及整治措施.     

封端率对PTMG型聚氨酯胶黏剂性能的影响

文章研究了用PTMG（聚四氢呋喃）、TDI（甲苯二异氰酸酯）,并用氨丙基三甲氧基硅烷（A-1110）封端合成PU（聚氨酯）胶黏剂。在合成过程中采用其他相关条件不变,仅改变封端率来制的系列胶膜,测试了胶膜的吸水率、力学性能、耐热性能。同时还运用透射电镜、红外光谱对所合成的材料进行了表征,实验结果表明：可知PU胶黏剂中已成功地引入了硅链节,较佳的封端率为5％-10％。     

不同煤种中可提取多环芳烃的分析

煤利用过程中释放多环芳烃类污染物带来重大环境问题,研究不同变质程度煤中PAHs的含量与分布可为煤利用过程中的PAHs的形成与释放控制提供资料。本文在对淮北煤中PAHs的提取分析的基础上,结合本实验室研究数据,着重分析了不同煤种对可提取多环芳烃含量、分布影响。研究认为煤中碳、氢、氧及其它煤质组分与可提取多环芳烃有着密切的关系。     

溴离子选择电极法研究温度和添加剂对CTAB的CMC的影响规律

用溴离子选择电极法测定十六烷基三甲基溴化铵在不同温度和不同添加剂存在下的临界胶束浓度,得到CMC的变化规律;随温度升高,CMC逐渐增大;随有机醇中烷基复杂程度的增加,CMC逐渐降低;随无机盐中负离子电荷数升高,CMC明显降低．     

亭南煤矿综放开采矿山压力数值模拟

为了分析综放工作面顶板断裂、垮落形式,以及工作面支承压力分布及影响区域范围,对亭南煤矿101综放面,分别应用UDEC与FLAC3D软件进行了数值模拟对比分析.结果表明随工作面的推进,直接项出现离层、破断,并在采空区前后煤壁上方基岩出现拉裂缝.当工作面推进到60m左右,老顶出现初次破断,形成初次来压,之后工作面每推进30 m,老项出现周期来压.模拟结果再现了顶板冒落、离层、破断,综放面初次、周期来压及围岩应力集中、重新分布等现象,这些结果与现场矿山压力观测结果基本吻合,为矿压观测提供了直观、准确的数值分析方法.     

Construction of the glucose isomerase deficient strain ofStreptomyces M1033 by homologous recombination

After the establishment of the transformation conditions ofStreptomyces diastaticus No.7 Strain M1033, the integration plasmid pXW for homologous recombination, which contains a 600 bp fragment of incompleteGI (G138P. G247D) gene, has been constructed in order to realize the stable overexpression of theGI (G138P. G247D) which is valuable for large-scale industrial production. The Gigene’s disruption has been realized by pXW’s integration into M1033 chromosomes via homologous recombination andGI deficient strain ofStreptomyces M1033 has been obtained. The reliability of introduction of mutation has been proved by analysis of recombinant fragment and affirmance of existence of the mutation, as well as detection of the stability of the deficient strain.     

用ObjectARX开发标准件参数化绘图系统

介绍了在AutoCADR14下应用其面向对象的开发工具ObjectARX 2 0 ,采用可视化程序设计语言VisualC 5 0开发标准机械零件参数化图形库及绘图系统的技术方法 ,并以螺栓库为例 ,说明了利用标准件库进行参数化绘图的过程     

逆极限空间上的移位映射的(几乎)等度连续性和刚性

设X为紧致度量空间,f:X→X为连续映射,σ:(?)(X,f)→(?)(X,f)为移位映射.本文证明了:(1)如果f为拓扑传递的,那么σ为几乎等度连续的(等度连续的)当且仅当f为几乎等度连续的(等度连续的).(2)如果f为满射,那么σ为弱刚性的(一致刚性的)当且仅当f为弱刚性的(一致刚性的).