生长曲线模型中的联合影响分析

本文讨论了生长曲线模型中多组数据对回归分析的联合影响问题,给出了度量准则及其化简式与统计解释,推广了已有文献中的有关结果.     

Lactate dehydrogenase specificity and subunit assembly in neural tissues of the teleostPhallichthys amates

Summary The tissue specificity of lactate dehydrogenase (EC 1.1.1.27) in brain and eye of the teleostPhallichthys amates was examined by acrylamide gel electrophoresis. It is suggested that subunit association is a function of gene product accessibility superimposed upon genetic restriction of assembly.     

单核苷酸多态性研究进展及其在法庭科学中的应用

单核苷酸多态性(Singlenucleotidepolymorphism,SNP)是人类基因组中单个碱基的变异,其最低基因频率不低于1%,是倍受关注的第三代多态性遗传标记,为法医物证检验提供了新的方向,本文就其研究最新进展、应用及检测手段作一综述.     

食管癌地理环境病因研究

作者试图对我国自七十年代开始的食管癌地理环境病因研究中的有关强致癌物亚硝胺的物质来源问题进行一次较为全面的探讨。从国外同类研究工作开始,较为客观地分析了各种环境致癌学说。     

Host cell reactivation of ozone-treated T3 bacteriophage by different strains ofEscherichia coli

Summary Host cell reactivation capacity for ozone T3 phage was determined for differentE. coli strains deficient in one or more of the DNA repair mechanisms. The results indicate that DNA polymerase I appears to play a key role in the repair of damage produced on the DNA by ozone while thelexA gene product seems to play a minor one.This research was sponsored by the National Sciences and Engineering Council of Canada. One of us (PLH) acknowledges a scholarship from the NSERCof Canada.     

高校领导干部代际转移中作风建设的若干思考

本文针对高校领导干部代际转移中作风建设的实际,论述了加强新一代高校领导干部作风建设的基本要点,并据以提出抓好这项工作的三种途径.     

大学扩招与质量问题刍议

为了进一步实施科教兴国战略,提高全民族的整体素质,尽快培养大批适应现代化需要的高素质的劳动者和各类专门人才,1999年6月,党中央、国务院作出了扩大高等学校招生规模的重大决策,高等教育以前所未有的规模和速度发展.……     

Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.

During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is accomplished through spontaneous folding to a thermodynamically stable and active native state. However, in the extracellular bacterial alpha-lytic protease (alphaLP) these two processes have become decoupled. The native state of alphaLP is thermodynamically unstable, and when denatured, requires millennia (t1/2 approximately 1,800 years) to refold. Folding is made possible by an attached folding catalyst, the pro-region, which is degraded on completion of folding, leaving alphaLP trapped in its native state by a large kinetic unfolding barrier (t1/2 approximately 1.2 years). alphaLP faces two very different folding landscapes: one in the presence of the pro-region controlling folding, and one in its absence restricting unfolding. Here we demonstrate that this separation of folding and unfolding pathways has removed constraints placed on the folding of thermodynamically stable proteins, and allowed the evolution of a native state having markedly reduced dynamic fluctuations. This, in turn, has led to a significant extension of the functional lifetime of alphaLP by the optimal suppression of proteolytic sensitivity.     

Quantum Mechanics and Operational Probability Theory

We discuss a generalization of the standard notion of probability space and show that the emerging framework, to be called operational probability theory, can be considered as underlying quantal theories. The proposed framework makes special reference to the convex structure of states and to a family of observables which is wider than the familiar set of random variables: it appears as an alternative to the known algebraic approach to quantum probability.     

TV跟踪系统光电轴一致性研究

本文论述复合制导系统 ＴＶ光电设备光电轴一致性问题，并给出新的处理方法。研究结果表明：本方法具有较高的精度与应用价值。