热处理对以Al2O3为绝缘层的并五苯薄膜晶体管性能的影响

采用阳极氧化法制备了Al_2O_3绝缘材料,并制备了以Al_2O_3为绝缘层的并五苯薄膜晶体管器件(OTFT)。Al_2O_3绝缘层经过10 min 350℃氢热处理后,OTFT迁移率比未经氢热处理的增大近20倍,且阈值电压降到了-7 V。Al_2O_3膜MIS结构电容—电压(C–V)特性的平带电压平移量数据表明,Al_2O_3膜经过热处理后,并五苯半导体与Al_2O_3绝缘体界面处以及绝缘体内缺陷态密度显著地降低,Al_2O_3绝缘层和并五苯半导体层之间的接触得到改善,这使得经热处理Al_2O_3膜的OTFT器件性能得到显著的改善。     

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative pathways, the result is cellular toxicity and neurodegeneration. Cellular mechanisms for degrading misfolded protein include the ubiquitin-proteasome system (UPS), the main non-lysosomal degradative pathway for ubiquitinated proteins, and autophagy, a lysosome-mediated degradative pathway. The UPS and autophagy have long been viewed as complementary degradation systems with no point of intersection. This view has been challenged by two observations suggesting an apparent interaction: impairment of the UPS induces autophagy in vitro, and conditional knockout of autophagy in the mouse brain leads to neurodegeneration with ubiquitin-positive pathology. It is not known whether autophagy is strictly a parallel degradation system, or whether it is a compensatory degradation system when the UPS is impaired; furthermore, if there is a compensatory interaction between these systems, the molecular link is not known. Here we show that autophagy acts as a compensatory degradation system when the UPS is impaired in Drosophila melanogaster, and that histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase that interacts with polyubiquitinated proteins, is an essential mechanistic link in this compensatory interaction. We found that compensatory autophagy was induced in response to mutations affecting the proteasome and in response to UPS impairment in a fly model of the neurodegenerative disease spinobulbar muscular atrophy. Autophagy compensated for impaired UPS function in an HDAC6-dependent manner. Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner. This study suggests that impairment of autophagy (for example, associated with ageing or genetic variation) might predispose to neurodegeneration. Morover, these findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy.     

基于信息平台整合对高职院校毕业设计过程监控信息化研究

随着社会的发展,信息技术的进步,教育信息化特别是实践教学信息化具有重要研究意义.基于地方信息平台的整合,提出了高职高专院校毕业论文(设计)过程监控网络信息化.先设计了毕业论文(设计)信息平台结构,从而把政、校、企对学生进行共同培养模式进行了有机的结合;再从出题、选题、论文答辩、论文成果转化等方面对毕业论文(设计)管理实现了信息化;通过理论分析与实践证明此信息化过程有一定的理论意义和实用价值.     

基于MSP430F5438A的工业排污督察管理终端设计

工业排污占环境污染高达70％,传统水质监测方法效率低且排污企业暗自偷排、突排污水问题严重,为此设计了一款基于MSP430F5438A和北斗的工业排污督察管理终端.工业排污督察管理终端以MSP430F5438A为核心控制器,利用北斗定位模块定位排污口位置并借助水质检测单元实时采集pH值、温度、浑浊度、溶解氧、氨氮浓度等信...     

基于深度贝叶斯网络学习的不确定性建模方法

战场态势评估涉及很多不确定因素,对不确定性进行仿真建模能够提高态势评估的能力。针对参战对象多元、不确定性增多导致的无法全面准确表达不确定性问题,提出了基于记忆模块和变分自编码器的深度贝叶斯网络模型。采用生成模型设计了基于深度贝叶斯网络学习的态势评估模型;阐述了融合记忆模块的深度生成模型原理和模型的学习与推理过程;以某空袭行动为例构建贝叶斯网络,对所提方法进行了验证。结果表明:深度神经网络能够逼近隐变量的非线性变换,设计的记忆模块能存储深度神经网络提取的大量局部特征,通过学习自动得到了贝叶斯网络条件概率,增强了不确定性建模能力。     

一种检测氯胺酮的新方法

目的:寻找检验氯胺酮的试剂。方法:用化学方法进行检验,根据颜色反应进行识别。结果:氯胺酮与硫氰酸钴混合溶液反应,出现了特征性的紫色沉淀物。结论:该方法具有操作简便,结果准确,特异性强,便于推广的优势,可用于氯胺酮的初步检验。     

Connecting informal networks to management of tacit knowledge

The relationship between tacit knowledge and informal networks has not been fully explored.Tacit knowledge cannot be well managed directly,because it is deeply embedded in individual actions and experiences.This study proposes an approach to managing informal networks as a new middle way to facilitate the sharing and transferring of tacit knowledge,owing to the fact that tacit knowledge is mostly shared and transferred through informal networks.To support the idea of the approach,an empirical case study of applying the approach to management of a large scientific project is also included.Our findings suggest that informal networks play essential roles for management of tacit knowledge,and thus good management of informal networks can lead to efficient sharing and transferring of tacit knowledge.     

竖井井壁竖向附加力的理论计算方法

从弹性力学的空间轴对称问题出发,从理论上推导建立了竖井竖向附加力的应力表达式.分析该应力表达式可知,在竖向附加力作用下,井壁所受的径向、环向压应力值均为零,竖向附加力对井壁的作用主要体现为轴向压应力,且轴向应力在沿井壁厚度方向几乎无变化,因而可以将作用在井壁外侧的竖向附加力等效为作用在井壁横截面上的均布力.利用该应力表达式对某铁矿竖井井壁竖向附加力进行了计算,得到了井壁应力状况.     

假颗粒现象及其对再生铝镁碳制品性能的影响

对用后铝镁碳砖再生颗粒料的组成和结构特点进行显微分析,并通过改变混料方式以及不同粒度再生料的加入量研究假颗粒对再生铝镁碳制品结构与性能的影响.结果表明:用后铝镁碳砖再生料中含有约40%与废砖相组成和结构相似、骨料与基质并存于同一颗粒的二次颗粒,即所谓的"假颗粒",假颗粒的组成、结构及外形的均匀程度均远不如一次骨料颗粒;混碾可使用后铝镁碳砖再生料中假颗粒发生二次破碎,且粒度越大,发生二次破碎的颗粒数量越多;假颗粒二次破碎导致再生制品的粒度组成发生改变,进而影响其密度和耐压强度.     

库容有限且有批量折扣的不允许缺货存贮模型

Ｗｉｌｓｏｎ公式隐含着用户仓库容量足够大，单价与订购批量无关的假设，这一假设往往与实际情况相悖。为此，本文提出了仓库容量有限且有批量折扣条件下不允许缺货存贮模型，并通过实例说明了模型的应用。