基于创新能力培养的食品微生物学教学改革

以创新性能力培养为目标对食品微生物学的理论和实践教学进行了一系列改革。在理论教学方面通过优化课程知识体系、创新课程教学手段、改革课程考核模式,构建了"知识点"与"能力点"并重的教学体系;在实践教学方面通过优化实验项目、革新教学手段、完善考核方式,形成了技能和意识并重的教学理念。通过这些改革措施的实践,学生在自主学习能力、课堂参与激情、创新兴趣等方面得到了明显提高。     

缺失数据下线性EV模型的稳健参数估计

给出了多元线性EV模型下协变量具有随机缺失(MAR)时参数的稳健估计方法,并证明了估计的渐近正态性.模拟研究表明估计量在有限样本下具有很好的效果.     

上市公司信用风险测度的不确定性DE-KMV模型

研究不确定性KMV信用风险测度问题,用差分进化算法(DE)来优化违约点系数,提出一种中国上市公司信用风险测度的不确定性DE-KMV模型.实证结果表明,常用的KMV模型往往低估了中国上市公司的风险值,而不确定性DE-KMV模型在面对中国上市公司各种风险情况下的违约系数值与实际风险很接近,模型通过分位数回归分析,其系数在置信区间内显著性更好.因此,相对于常用的KMV模型,化模型更据灵活性,能提高上市公司信用风险测度的准确性.     

关于Fischer不等式的研究

给出了Fischer不等式的形式,通过Fischer不等式的一般性质将其推广到n阶分块矩阵以及m×n阶分块矩阵中,得出关于Fischer不等式的其他性质以及相应的一些结论.     

水热合成单分散碳球的制备与表征

以葡萄糖为原料水热法合成粒径均一单分散碳球,研究反应时间、反应温度、葡萄糖浓度、pH值、甲醛用量对碳球形貌及粒径的影响,采用SEM、FTIR、XRD对碳球的形貌和结构进行表征。结果表明,单分散碳球的最佳制备工艺为:反应温度160℃、反应时间6h、葡萄糖浓度0.25mol/L、体系pH值为8、甲醛用量2g;所制碳微球粒径约为350nm,分散系数为0.011,产率约为20%;制备出的碳球表面含有—OH、—CO、COOH官能团,碳球中含有无定形炭。     

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on gene expression parallel those observed for the histone deacetylases. We demonstrated that F- and Cl-amidine, two potent PAD4 inhibitors, display micromolar cytotoxic effects towards several cancerous cell lines (HL-60, MCF7 and HT-29); no effect was observed in noncancerous lines (NIH 3T3 and HL-60 granulocytes). These compounds also induced the differentiation of HL-60 and HT29 cells. Finally, these compounds synergistically potentiated the cell killing effects of doxorubicin. Taken together, these findings suggest PAD4 inhibition as a novel epigenetic approach for the treatment of cancer, and suggest that F- and Cl-amidine are candidate therapeutic agents for this disease.     

A Note on the Property of ψ-Function

About the accurate value of ψ ( x ) = Γ′ ( x ) / Γ ( x), we know only ψ (1)and ψ (1/ 2).In this paper, by calculating the accurate values of some series expansion of a function and applying some skills of complex analysis, we prove that the expression of the ψ-function admits a finite expression in elementary function for rational number z. As an application, some examples are given.     

The role of endosomal-recycling in long-term potentiation

Long-term potentiation (LTP) defines persistent increases in neurotransmission strength at synapses that are triggered by specific patterns of neuronal activity. LTP, the most widely accepted molecular model for learning, is best characterised at glutamatergic synapses on dendritic spines. In this context, LTP involves increases in dendritic spine size and the insertion of glutamate receptors into the post-synaptic spine membrane, which together boost post-synaptic responsiveness to neurotransmitters. In dendrites, the material required for LTP is sourced from an organelle termed the endosomal-recycling compartment (ERC), which is localised to the base of dendritic spines. When LTP is induced, material derived from the recycling compartment, which contains α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-type glutamate receptors (AMPARs), is mobilised into dendritic spines feeding the increased need for receptors and membrane at the spine neck and head. In this review, we discuss the importance of endosomal-recycling and the role of key proteins which control these processes in the context of LTP.     

Co-substituted ATS-type molecular sieves and films for cyclohexane oxidation

Pure CoAPO-36 crystal grains were synthesized by hydrothermal reaction. Porous α-Al₂O₃, stainless steel and K₂Ti₆O₁₃ supported CoAPO-36 films were fabricated using in situ crystallization for the first time. SEM images and XRD measurements demonstrate that a continuous CoAPO-36 film was obtained on the K₂Ti₆O₁₃ substrate. Diffuse reflectance UV-Vis spectra indicate that Co²⁺ has been incorporated into the ATS framework. Both CoAPO-36 crystal grains and the K₂Ti₆O₁₃ supported CoAPO-36 film exhibit satisfactory catalytic activities for the oxidation of cyclohexane.     

BotGuard: Lightweight real-time botnet detection in software defined networks

The distributed detection of botnets may induce heavy computation and communication costs to network devices. Each device in related scheme only has a regional view of Internet, so it is hard to detect botnet comprehensively. In this paper, we propose a lightweight real-time botnet detection framework called Bot-Guard, which uses the global landscape and flexible configurability of software defined network (SDN) to identify botnets promptly. SDN, as a new network framework, can make centralized control in botnet detection, but there are still some challenges in such detections. We give a convex lens imaging graph (CLI-graph) to depict the topology characteristics of botnet, which allows SDN controller to locate attacks separately and mitigate the burden of network devices. The theoretical and experimental results prove that our scheme is capable of timely botnet detecting in SDNs with the accuracy higher than 90% and the delay less than 56 ms.