The culture of goldfish cells (Carassius auratus) at high temperatures

Résumé Les cellules deCarassius auratus ont été cultivées in vitro avec succès à des températures allant jusqu'à 39 °C, les cellules du testicule en séries de 28 sous-cultures à 31.5 °C et 6 sous-cultures à 37.5 °C.     

Colorectal cancer: mutations in a signalling pathway

Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.