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Oxygenic photosynthesis is the principal producer of both oxygen and organic matter on Earth. The conversion of sunlight into chemical energy is driven by two multisubunit membrane protein complexes named photosystem I and II. We determined the crystal structure of the complete photosystem I (PSI) from a higher plant (Pisum sativum var. alaska) to 4.4 A resolution. Its intricate structure shows 12 core subunits, 4 different light-harvesting membrane proteins (LHCI) assembled in a half-moon shape on one side of the core, 45 transmembrane helices, 167 chlorophylls, 3 Fe-S clusters and 2 phylloquinones. About 20 chlorophylls are positioned in strategic locations in the cleft between LHCI and the core. This structure provides a framework for exploration not only of energy and electron transfer but also of the evolutionary forces that shaped the photosynthetic apparatus of terrestrial plants after the divergence of chloroplasts from marine cyanobacteria one billion years ago. 相似文献
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Adaptation of core mechanisms to generate cell polarity 总被引:34,自引:0,他引:34
Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of multi-cell organisms such as epithelia in worms, flies and mammals. This diversity raises several questions: do different cell types use different mechanisms to generate polarity, how is polarity signalled, how do cells react to that signal, and how is structural polarity translated into specialized functions? Analysis of evolutionarily diverse cell types reveals that cell-surface landmarks adapt core pathways for cytoskeleton assembly and protein transport to generate cell polarity. 相似文献
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Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels 总被引:21,自引:0,他引:21
Calcitonin gene-related peptide (CGRP) is a 37-amino-acid peptide produced by alternative processing of messenger RNA from the calcitonin gene. CGRP is one of the most potent vasodilators known. It occurs in and is released from perivascular nerves and has been detected in the blood stream, suggesting that it is important in the control of blood flow. The mechanism by which it dilates arteries is not known. Here, we report that arterial dilations in response to CGRP are partially reversed by blockers of the ATP-sensitive potassium channel (K(ATP)), glibenclamide and barium. We also show that CGRP hyperpolarizes arterial smooth muscle and that blockers of K(ATP) channels reverse this hyperpolarization. Finally, we show that CGRP opens single K+ channels in patches on single smooth muscle cells from the same arteries. We propose that activation of K(ATP) channels underlies a substantial part of the relaxation produced by CGRP. 相似文献
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通过对一百多个星系形成数值模拟和试验的分析,现在可以对引力的树结构算法和平滑粒子流体力学(Smoothed Particle Hydrodynamics,SPH)这两种数值模拟技术的准确性和可靠性做定量的估计。这些结果表明若给SPH方法中使用的平滑半径(h)固定一个下限值,可能会导致数值解的准确性严重下降。若随时调整h的值使得SPH方法计算粒子的邻近粒子数总和保持不变,则可以避免这种有害的影响,使准确性得到提高。结果还表明为了可以准确地模拟原星系的坍缩,小心地选取那些影响引力加速度准确性的参量尤其重要。 相似文献
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Clark RN Brown RH Jaumann R Cruikshank DP Nelson RM Buratti BJ McCord TB Lunine J Baines KH Bellucci G Bibring JP Capaccioni F Cerroni P Coradini A Formisano V Langevin Y Matson DL Mennella V Nicholson PD Sicardy B Sotin C Hoefen TM Curchin JM Hansen G Hibbits K Matz KD 《Nature》2005,435(7038):66-69
The origin of Phoebe, which is the outermost large satellite of Saturn, is of particular interest because its inclined, retrograde orbit suggests that it was gravitationally captured by Saturn, having accreted outside the region of the solar nebula in which Saturn formed. By contrast, Saturn's regular satellites (with prograde, low-inclination, circular orbits) probably accreted within the sub-nebula in which Saturn itself formed. Here we report imaging spectroscopy of Phoebe resulting from the Cassini-Huygens spacecraft encounter on 11 June 2004. We mapped ferrous-iron-bearing minerals, bound water, trapped CO2, probable phyllosilicates, organics, nitriles and cyanide compounds. Detection of these compounds on Phoebe makes it one of the most compositionally diverse objects yet observed in our Solar System. It is likely that Phoebe's surface contains primitive materials from the outer Solar System, indicating a surface of cometary origin. 相似文献