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741.
Effect of N 6 O 2 -dibutyryl cyclic 3',5'-adenosine monophosphate on the pinocytosis of brain capillaries of mice 总被引:1,自引:0,他引:1
F Joó 《Experientia》1972,28(12):1470-1471
742.
743.
In this paper the underlying systemic unity of the research reported in the two previous articles is sought. The research journey is examined in order to draw lessons concerning our systemic practice. In addition, an effort is made to relate Interpretive Systemology to some strands of systems, management and action research sciences. In so doing, we expect to draw some links that could be established between interpretive systemologists and the community of researchers who compose the select audience of SPAR. 相似文献
744.
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. 总被引:26,自引:0,他引:26
M Bodzioch E Orsó J Klucken T Langmann A B?ttcher W Diederich W Drobnik S Barlage C Büchler M Porsch-Ozcürümez W E Kaminski H W Hahmann K Oette G Rothe C Aslanidis K J Lackner G Schmitz 《Nature genetics》1999,22(4):347-351
Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism. It is characterized by absence of plasma high-density lipoprotein (HDL) and deposition of cholesteryl esters in the reticulo-endothelial system with splenomegaly and enlargement of tonsils and lymph nodes. Although low HDL cholesterol is associated with an increased risk for coronary artery disease, this condition is not consistently found in TD pedigrees. Metabolic studies in TD patients have revealed a rapid catabolism of HDL and its precursors. In contrast to normal mononuclear phagocytes (MNP), MNP from TD individuals degrade internalized HDL in unusual lysosomes, indicating a defect in cellular lipid metabolism. HDL-mediated cholesterol efflux and intracellular lipid trafficking and turnover are abnormal in TD fibroblasts, which have a reduced in vitro growth rate. The TD locus has been mapped to chromosome 9q31. Here we present evidence that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22-31. We have analysed five kindreds with TD and identified seven different mutations, including three that are expected to impair the function of the gene product. The identification of ABC1 as the TD locus has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease. 相似文献
745.
Spatial vegetation patterns and imminent desertification in Mediterranean arid ecosystems 总被引:2,自引:0,他引:2
Kéfi S Rietkerk M Alados CL Pueyo Y Papanastasis VP Elaich A de Ruiter PC 《Nature》2007,449(7159):213-217
Humans and climate affect ecosystems and their services, which may involve continuous and discontinuous transitions from one stable state to another. Discontinuous transitions are abrupt, irreversible and among the most catastrophic changes of ecosystems identified. For terrestrial ecosystems, it has been hypothesized that vegetation patchiness could be used as a signature of imminent transitions. Here, we analyse how vegetation patchiness changes in arid ecosystems with different grazing pressures, using both field data and a modelling approach. In the modelling approach, we extrapolated our analysis to even higher grazing pressures to investigate the vegetation patchiness when desertification is imminent. In three arid Mediterranean ecosystems in Spain, Greece and Morocco, we found that the patch-size distribution of the vegetation follows a power law. Using a stochastic cellular automaton model, we show that local positive interactions among plants can explain such power-law distributions. Furthermore, with increasing grazing pressure, the field data revealed consistent deviations from power laws. Increased grazing pressure leads to similar deviations in the model. When grazing was further increased in the model, we found that these deviations always and only occurred close to transition to desert, independent of the type of transition, and regardless of the vegetation cover. Therefore, we propose that patch-size distributions may be a warning signal for the onset of desertification. 相似文献
746.
Hinke CB Böhmer M Boutachkov P Faestermann T Geissel H Gerl J Gernhäuser R Górska M Gottardo A Grawe H Grębosz JL Krücken R Kurz N Liu Z Maier L Nowacki F Pietri S Podolyák Z Sieja K Steiger K Straub K Weick H Wollersheim HJ Woods PJ Al-Dahan N Alkhomashi N Ataç A Blazhev A Braun NF Čeliković IT Davinson T Dillmann I Domingo-Pardo C Doornenbal PC de France G Farrelly GF Farinon F Goel N Habermann TC Hoischen R Janik R Karny M Kaşkaş A Kojouharov IM Kröll T Litvinov Y Myalski S Nebel F 《Nature》2012,486(7403):341-345
The shell structure of atomic nuclei is associated with 'magic numbers' and originates in the nearly independent motion of neutrons and protons in a mean potential generated by all nucleons. During β(+)-decay, a proton transforms into a neutron in a previously not fully occupied orbital, emitting a positron-neutrino pair with either parallel or antiparallel spins, in a Gamow-Teller or Fermi transition, respectively. The transition probability, or strength, of a Gamow-Teller transition depends sensitively on the underlying shell structure and is usually distributed among many states in the neighbouring nucleus. Here we report measurements of the half-life and decay energy for the decay of (100)Sn, the heaviest doubly magic nucleus with equal numbers of protons and neutrons. In the β-decay of (100)Sn, a large fraction of the strength is observable because of the large decay energy. We determine the largest Gamow-Teller strength so far measured in allowed nuclear β-decay, establishing the 'superallowed' nature of this Gamow-Teller transition. The large strength and the low-energy states in the daughter nucleus, (100)In, are well reproduced by modern, large-scale shell model calculations. 相似文献