Inhibition of endotoxin-induced platelet agglutination,histamine and serotonine releasein vitro by thiol-compounds

Zusammenfassung Es wird festgestellt, dass gewisse Thiolverbindungen wie Cystein, Mercaptoethanol, Thioglycolsäure und AET die von Endotoxin ausgelöste Thrombocyten-Agglutination, die Freisetzung von Histamin und Serotonin im Kaninchen-Thrombocytenplasma hemmen.     

Glutathione andγ -glutamyl cycle enzymes in rat mammary gland

Summary The main enzymes of theγ-glutamyl cycle during the lactogenic cycle in rat mammary gland were studied. A significant increase was found in all of them with the onset of lactogenesis. The effect of methionine sulfoximine on reduced glutathione concentration was studied in tissue slices of lactating mammary gland. The findings suggest that this compound affects glutathione synthesis by inhibitingγ-glutamylcysteine synthetase. This work was supported by grant B1138-8223 from the Servicio de Desarrollo Cientifico, Universidad de Chile.     

A novel xanthone as secondary metabolite fromCentaurium cachanlahuen

Summary From the plantCentaurium cachanlahuen, swertiaperenine1, swercherine2, decusatine4, oleanolic acid5 and the xanthone 1,8-dihydroxy-2,3,4,6-tetramethoxy-9H-xanthone3 were isolated and characterized.     

An escape phenomenon from water and sodium retention induced by propranolol in rats

Rats given a daily dose of propranolol 45 mg/kg b.wt retain water and sodium for 4 days, escaping during the 5th and 6th days in which their excretions are larger than basal values. Afterwards, in the period studied, they make a new retention and clearing is less accentuated. No relationship could be found between these retentions and plasma renin activity or renal renin content.     

The effect of kryptopyrrole on the porphyrin auxotrophic strains ofBacillus subtilis

Zusammenfassung Nachweis, dass Kryptopyrrol zwar die Porphyrinsynthese inBacillus subtilis Wildtyp stimuliert, nicht aber das Wachstum von Porphyrin-Mangelmutanten dieses Bakteriums ermöglichen kann.     

Local monoclonal immunoglobulin production in cancer patient

Résumé La technique directe de l'immunofluorescence a permis de mettre en évidence dans un ganglion lymphatique adjacent à la tumeur cancéreuse du rectum la présence de nombreuses cellules sécrétant de IgG monoclonal.

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This work was supported by a grant No. 09.3.2. of the Polish Academy of Sciences.     

Unification of Mathematical Theories

In this article the problem of unification of mathematical theories is discussed. We argue, that specific problems arise here, which are quite different than the problems in the case of empirical sciences. In particular, the notion of unification depends on the philosophical standpoint. We give an analysis of the notion of unification from the point of view of formalism, Gödel's platonism and Quine's realism. In particular we show, that the concept of “having the same object of study” should be made precise in the case of mathematical theories. In the appendix we give a working proposal of a certain understanding of this notion.     

Regulation of lymphokine production in peripheral blood mononuclear cell cultures

Summary An increase in the production of macrophage migration inhibitory factor, chemotactic factor for neutrophils, and skin reactive factor, was observed in lymphocyte cultures if the cells were allowed to age in culture for 24 h. The increased lymphokine production was reduced by adding concanavalin A-stimulated and mitomycin C-treated suppressor cells. It is suggested that the lymphokine production could be regulated by suppressive mononuclear cells.This work was supported by the Scientific Research Council, Ministry of Health, Hungary (Code No. 421 0304011/S).