MYH9 is associated with nondiabetic end-stage renal disease in African Americans

As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.     

RH精炼钢中全氧量变化与操作改进

为了使钢中全氧量控制在一个适当的水平,在武钢炼钢总厂RH真空脱气装置对低碳、超低碳钢进行了脱氧净化试验.结果表明,影响全氧去除的因素按作用高低依次是出钢溶解氧水平,溶解氧与钢包渣的交互作用,钢包渣,和真空处理净化时间.通过改进工艺生产了全氧量≤10×10-6,非金属夹杂物尺寸<10μm的清洁钢水,建立了一个钢包内钢水全氧浓度随时间变化的新方程,该方程考虑了全氧的表观平衡含量及环流、扩散传质对去除氧化物夹杂速率的影响.     

Universal Distributed Estimation Scheme for a Bandwidth Constrained Ad Hoc Sensor Network

This paper describes a distributed estimation scheme (DES) for a bandwidth constrained ad hoc sensor network.The DES is universal in the sense that operations on all sensors are identical and independent of noise distribution.The scheme requires each sensor to transmit just a 1-bit message per observation.Simulation results show that the scheme achieves much better mean-squares error (MSE) performance than the simplified isotropic universal DES and even outperforms the isotropic universal DES which requires more than twice the bandwidth of this scheme.     

Applying File Information to Block-Level Content Addressable Storage

Content addressable storage (CAS) is a promising technology for improving storage efficiency as well as access throughput.Currently,many CAS products are implemented on the block level,which results in loss of file information.Thus,some sophisticated optimizations cannot be achieved,such as accurate fileprefetching.This paper presents a file-aware block-level storage system combined with the CAS function.In contrast with some existing file-level CAS,this system is transparent to upper-level applications,including the operating system and the file system.These features are achieved by using smart-disk technologies to help the storage system to learn the file-system layout.A prototype was implemented on an open-source virtual machine (VM) with the guest operating system being Windows XP.Tests show that this combination significantly reduces the size of the VM image file and improves the storage performance by discarding unused blocks and using a simple file-level prefetching strategy.     

公益工商研究所始末

本文系统地介绍了由中国最大的民族资本集团——荣家企业经营的公益工商研究所的创办过程及其所进行的研究课题和所取得的成果。文中指出该所是为荣家企业的生存和发展服务的,是集工业、科技、经济于一体的研究机构。     

月桂酸氯仿溶液萃取Nd（Ⅲ）机理研究

在20±1℃、μ=0.1(NaClO_4)条件下,研究了月桂酸氯仿溶液萃取Nd(Ⅲ)机理。假定的萃取反应为:结果表明,上述萃取反应平衡式中j=1和a=0,并得到萃取反应平衡常数为     

利用计算机综合分析卧式多分室连续结晶设备

根据卧式多分室连续结晶设备的运行情况,本文选择五个影响这类结晶设备的主要因素,通过编译的计算机程序CCP1进行综合性分析考察,了解了有关因素在蔗糖连续结晶过程中的作用,为实现卧式多分室连续结晶设备的系统控制提供了一定的理论基础。     

粉末冶金多孔阻焰材料临界熄火孔径的控制

在制取粉末冶金多孔阻焰材料时,根据Pekle准数推算出燃气火焰熄灭的临界熄火孔径值,依据此值来确定原料粉末粒度和制取工艺参数,从而可使所制材料的孔径准确符合临界熄火孔径值要求,其材料能有效地发挥阻焰、熄火、防爆作用。     

线性系统的特征结构配置

本文讨论线性系统状态反馈的特征结构配置问题,给出可配置根系的必要充分条件,指出其结构特征,并用例子说明根系的选择过程及反馈矩阵的求法。