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421.
多元触觉和沉浸式视觉反馈的时空一致性配准以及现有VR软件框架中硬件设备的接入便捷性问题,制约了医疗、商务、娱乐等不同行业中视触觉融合场景的快速开发。为解决这一难题,提出融合多元触觉和沉浸式视觉的可移植VR软件框架,根据视触觉反馈精度要求的不同设计了双层和三层架构兼顾视觉渲染、触觉渲染、硬件控制的不同需求。实验结果表明该框架具有支持视-触融合同步反馈、硬件平台可移植、图形场景开发简便和交互场景可快速替换等特点,能够满足不同领域的交互应用需求。 相似文献
422.
针对空基外辐射源定位(airborne external transmitter location, AETL)系统的可观测性问题,建立了AETL系统的二维运动学模型与量测方程,基于离散化的非线性可观测理论求解系统的可观测矩阵,并分析证明了系统不可观测的条件。基于矩阵分析理论的条件数定义了系统的可观测度,并仿真分析了观测站运动参数以及目标和外辐射源的机动参数对系统可观测度的影响。结果表明,当观测站与目标和外辐射源共线或目标和外辐射源保持径向运动时系统不可观测;当系统可观测时,观测站与目标和外辐射源之间的相对速度越小,系统可观测度越大。研究结果可为观测站制定机动策略提高系统定位性能提供有效的参考依据。 相似文献
423.
Journal of Systems Science and Complexity - Nonlinear feedback shift registers (NFSRs) are widely used as building blocks in the design of stream ciphers. Let NFSR(f) be an NFSR with the... 相似文献
424.
DFM (Design-For-Manufacturability) method, which aims to improve manufacturability of ICs through specific design considerations, is becoming important nowadays. In particular, standard cells now should be designed by DFM method. This paper reports a new DFM flow for sub-100 nm standard cell design with a group of technologies for process modeling, manufacturability simulation and trial RETs. Based on this flow, a set of DFM-friendly 90nm standard cells were designed. 相似文献
425.
Pan Li Guoying Zheng Yan Yang Chunguang Zhang Ping Xiong Yong Xu Min Fang Zheng Tan Fang Zheng Feili Gong 《Cellular and molecular life sciences : CMLS》2010,67(18):3197-3208
When they recognize a target cell, natural killer (NK) cells mount an attack to kill the target by exerting their cytotoxicity
via the exocytosis of cytotoxic granules. Although the details of this process (which includes the movement of cytotoxic granules
in the immune synapse and their fusion with the plasma membrane, releasing granzymes and perforin into the synaptic cleft)
are relatively better understood, the post-exocytosis regulation of the process is still largely unknown. Here we show that
a clathrin-dependent endocytosis stimulated by target cell occurs in NK92 cell line, which is closely correlated with granzyme
B recovery. Inhibition of the endocytosis significantly attenuates the cytotoxicity of NK92 cells. The NK cell recovery of
its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation
of immune cells. 相似文献
426.
Hu Z Xia Y Guo X Dai J Li H Hu H Jiang Y Lu F Wu Y Yang X Li H Yao B Lu C Xiong C Li Z Gui Y Liu J Zhou Z Shen H Wang X Sha J 《Nature genetics》2012,44(2):183-186
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men. 相似文献
427.
Chen ZW 《Cellular and molecular life sciences : CMLS》2011,68(14):2409-2417
Accumulating evidence suggests that human γδ T cells act as non-classical T cells and contribute to both innate and adaptive
immune responses in infections. Vγ2 Vδ2 T (also termed Vγ9 Vδ2 T) cells exist only in primates, and in humans represent a
dominant circulating γδ T-cell subset. Primate Vγ2 Vδ2 T cells are the only γδ T cell subset capable of recognizing microbial
phosphoantigen. Since nonhuman primate Vγ2 Vδ2 T cells resemble their human counterparts, in-depth studies have been undertaken
in macaques to understand the biology and function of human Vγ2 Vδ2 T cells. This article reviews the recent progress for
immune biology of Vγ2 Vδ2 T cells in infections. 相似文献
428.
Gui Y Guo G Huang Y Hu X Tang A Gao S Wu R Chen C Li X Zhou L He M Li Z Sun X Jia W Chen J Yang S Zhou F Zhao X Wan S Ye R Liang C Liu Z Huang P Liu C Jiang H Wang Y Zheng H Sun L Liu X Jiang Z Feng D Chen J Wu S Zou J Zhang Z Yang R Zhao J Xu C Yin W Guan Z Ye J Zhang H Li J Kristiansen K Nickerson ML Theodorescu D Li Y Zhang X Li S Wang J Yang H Wang J Cai Z 《Nature genetics》2011,43(9):875-878
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer. 相似文献
429.
基于平均驱动自由度位移(ADDOFD)理论,同时考虑车身侧与排气系统侧的NVH性能,以及各阶模态频率的不同权值的影响,对某车型排气系统吊点位置进行优化布置,并对布置吊点后的排气系统做声学稳健性分析。实际应用表明该设计方法能对汽车排气系统悬挂点选择提供可行性参考建议,在整车开发的初期,有效预测和控制车身结构的NVH性能。 相似文献
430.