Ultrastrukturelle Aspekte des supraoptikohypophysären Systems in der hypophysektomierten Ratte

Summary The supraoptico-hypophyseal system in the hypophysectomized rat was studied by electron microscopy. Light microscopic observations hitherto reported that, after hypophysectomy the proximal cut end of the infundibular stalk becomes reorganized into a neural lobelike organ, could be reconfirmed. The ultrastructural aspect of the supraoptic cells following hypophysectomy was also described.     

Fine structure of the perivascular space of theGecko japonicus subcommissural organ

Zusammenfassung Im Verlauf von elektronenmikroskopischen Untersuchungen am Subkommissuralorgan (SKO) vonGecko japonicus wurden zwischen den SKO-Zellen und den Kapillaren breite perivaskuläre Spalträume beobachtet, die mit flockigen Substanzen gefüllt sind und mitunter quergestreifte Strukturen aufweisen. Die funktionelle Bedeutung dieser perivaskulären Spalträume wurde im Hinblick auf die basale Sekretion des SKO diskutiert.     

Reaction Kinetic Studies of Waste Polymer and Hydrolytic Chlorine in EOCN Production

EOCNs are widely used by electric and electronics industries and coating and adhesive fields（see Tab. 1）.     

A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis

Blue light regulates processes such as the development of plants and fungi and the behaviour of microbes. Two types of blue-light receptor flavoprotein have been identified: cryptochromes, which have partial similarity to photolyases, and phototropins, which are photoregulated protein kinases. The former have also been found in animals with evidence of essential roles in circadian rhythms. Euglena gracilis, a unicellular flagellate, abruptly changes its swimming direction after a sudden increase or decrease in incident blue light intensity, that is, step-up or step-down photophobic responses, resulting in photoavoidance or photoaccumulation, respectively. Although these photobehaviours of Euglena have been studied for a century, the photoreceptor molecules mediating them have remained unknown. Here we report the discovery and biochemical characterization of a new type of blue-light receptor flavoprotein, photoactivated adenylyl cyclase, in the photoreceptor organelle of Euglena gracilis, with molecular genetic evidence that it mediates the step-up photophobic response.     

Human genome analysis system

An automated DNA sequencing system, the collaborative effort of Japanese scientists and engineers, which has a potential output of up to 108,000 bases per day is described.     

Spontaneous recovery after experimental manipulation of the plane of beat in sperm flagella

It is generally accepted that the oscillatory beating characteristic of sperm flagella is the result of an ATP-induced sliding between the doublet microtubules of the flagellar axoneme, with these longitudinal forces being converted into a lateral bending moment by resistive components of the structure that limit the displacement. However, little is known about the mechanisms that regulate this sliding among the nine doublets of the cylindrical axoneme to produce the coordinated planar bending waves required for efficient sperm propulsion. We have investigated these mechanisms with a new procedure in which the sperm head is held in the tip of a vibrating micropipette. Data obtained by gradually rotating the plane of imposed vibration around the sperm axis indicate that the pattern of active sliding between the outer doublet tubules can rotate relative to the sperm head, and suggest that this active sliding is regulated in part by the central tubule complex.     

Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)

"Lysosomal glycogen storage disease with normal acid maltase" which was originally described by Danon et al., is characterized clinically by cardiomyopathy, myopathy and variable mental retardation. The pathological hallmark of the disease is intracytoplasmic vacuoles containing autophagic material and glycogen in skeletal and cardiac muscle cells. Sarcolemmal proteins and basal lamina are associated with the vacuolar membranes. Here we report ten unrelated patients, including one of the patients from the original case report, who have primary deficiencies of LAMP-2, a principal lysosomal membrane protein. From these results and the finding that LAMP-2-deficient mice manifest a similar vacuolar cardioskeletal myopathy, we conclude that primary LAMP-2 deficiency is the cause of Danon disease. To our knowledge this is the first example of human cardiopathy-myopathy that is caused by mutations in a lysosomal structural protein rather than an enzymatic protein.     

新型超导传感器的研制及其在热波实验中的应用

介绍一种新型超导传感器的研制方法与标定使用过程。超导传感器由直径４０μｍ,长为１．５ｍｍ的石英丝作基体,在其表面真空镀膜上金和锡而形成,金和锡形成一种超导材料。对超导传感器的标定,表明了它具有精度高的特点;其于传热学理论,推导出超导传感器时间常数的计算公式,从而证明了其响应快的。