一种基于局部信息最小二乘法的节点定位算法

针对一些面积较大、节点分布密度过低的实际应用场景中,由于节点间距离测量误差过大而导致定位算法结果精度较低的问题,提出一种根据各邻居节点相关信息划分为若干个局部网络块的节点定位算法.该算法首先将无线传感器网络节点定位技术与机器学习领域中的降维方法相结合;然后根据节点间的距离越近,测量精度越高的规则及在一定通信半径内的各邻居节点相关信息共建网络块;最后将网络块组建成全局坐标系,利用全局构建以及锚节点的具体信息映射出各节点的坐标.仿真实验结果表明,该算法较其他节点定位算法在节点定位精度方面表现更优.     

非限域单体和水环境下Leu分子的手性转变机制

基于密度泛函理论B3LYP,在6-311+G(d,p)基组水平上研究非限域单体和水环境下亮氨酸(Leu)分子的手性转变机制.通过寻找反应过程中各极值点的结构,绘制水环境下Leu分子的手性转变路径反应势能面,并分析各极值点的几何和电子结构特性.结果表明:水环境下S型Leu分子手性C原子上的H原子以羧基上的O原子为桥梁,转移至手性C原子的另一侧,实现了从S型到R型Leu分子的手性转变;水环境下该路径有4个中间体和5个过渡态,来源于第一个过渡态TS1-S-Leu1H_2O-1的最大反应能垒为57.235 9kJ/mol,单体Leu分子手性转变第一个过渡态TS1-S-Leu的最大反应能垒为145.452 7kJ/mol.即单个水分子作为H转移桥梁可降低反应能垒.     

有限或无限区间连续生成元的一维反射倒向随机微分方程

得到了一类带单边连续下障碍的反射倒向随机微分方程（RBSDE）极小解的存在定理和比较定理，其生成元g满足广义线性增长条件且关于（y，z）连续，时间区间可以是有限或无限的．推广了倒向随机微分方程理论（BSDE）和RBSDE在一维情况下的相应结果．     

复杂动态环境下运动目标自动检测算法

针对复杂动态环境中运动目标难以精确检测的问题,提出了基于HSV颜色空间的运动目标检测算法。采用HSV颜色空间中背景减法解决运动目标颜色与背景相似和运动目标阴影影响导致运动目标难以准确检测问题;将背景区分为稳定背景和临时背景,提出双背景自动更新算法解决背景发生变化造成目标难以精确检测的问题;算法中引入表示背景变化程度的背景变化率,从而部分或全部更新背景。实验结果证明该方法能够准确检测运动目标。     

完善河北省社会保障体系建设的研究

社会保障是保障人民生活、调节收入分配的一项基本制度。河北省社会保障体系建设日趋完善,但仍存在制度碎片化、管理不统一、政策需完善、监管难到位等问题。通过社会保障制度的顶层设计、各项社保政策的有效衔接、社保体系的运行机制创新、社保资金的有力监管等措施,以完善河北省社会保障体系。     

Microstructure and electric characteristics of AETiO_3(AE=Mg,Ca, Sr)doped CaCu_3Ti_4O_(12) thin films prepared by the sol–gel method

This paper focuses on the effects of alkline-earth metal titante AETiO_3(AE = Mg,Ca,Sr) doping on the microstructure and electric characteristics of CaCu_3Ti_4O_(12) thin films prepared by the sol-gel method.The results showed that the grain size of CCTO thin films could be increased by MgTiO_3 doping.The movement of the grain boundaries was impeded by the second phases of CaTiO_3 and SrTiO_3 concentrating at grain boundaries in CaTiO_3 and SrTiO_3 doped CCTO thin films.Rapid ascent of dielectric constant could be observed in 0.1Mg TiO_3 doped CCTO thin films,which was almost as three times high as pure CCTO thin film and the descent of the dielectric loss at low frequency could also be observed.In addition,the nonlinear coefficient(α),threshold voltage(V_T) and leakage current(I_L) of AETiO_3 doped CCTO thin films(AE = Mg,Ca,Sr) showed different variation with the increasing content of the MgTiO_3,CaTiO_3 and SrTiO_3.     

全自动洗衣机传动机构设计

本文对全自动波轮式洗衣机的传动装置及控制系统结构进行了设计。通过设计了电动机选用、行星减速器两部分,达到了一台洗衣机通过电动机进行洗涤和脱水两种不同的工作状态,为相关结构设计提供借鉴。     

啤酒花潜隐病毒新疆分离物的全基因组序列分析

对新疆啤酒花上获得的HpLV分离物HpLV-XJ进行了全长克隆和基因组序列分析。结果显示:HpLV-XJ的全基因组序列为8612个核苷酸(nt)(不包括poly A),含有6个开放阅读框(ORF),分别编码224 kDa(ORF1)、25kDa(ORF2)、11 kDa(ORF3)、7 kDa(ORF4)、34 kDa(ORF5)、和12 kDa(ORF6)蛋白。序列相似性分析结果表明,HpLV-XJ与HpLV(GenBank:AB032469)序列相似性达98.5%,6个开放阅读框的核苷酸序列相似性分别为98.3%、99.0%、97.6%、96.7%、99.5%和98.4%;由此推导的氨基酸序列相似性分别为98.6%、98.7%、97.2%、95.0%、99.4%和98.1%,各个基因的核苷酸序列和蛋白的氨基酸之间存在着一定的差异。     

Modelling schizophrenia using human induced pluripotent stem cells

Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 80-85%. Although post-mortem studies have revealed reduced brain volume, cell size, spine density and abnormal neural distribution in the prefrontal cortex and hippocampus of SCZD brain tissue and neuropharmacological studies have implicated dopaminergic, glutamatergic and GABAergic activity in SCZD, the cell types affected in SCZD and the molecular mechanisms underlying the disease state remain unclear. To elucidate the cellular and molecular defects of SCZD, we directly reprogrammed fibroblasts from SCZD patients into human induced pluripotent stem cells (hiPSCs) and subsequently differentiated these disorder-specific hiPSCs into neurons (Supplementary Fig. 1). SCZD hiPSC neurons showed diminished neuronal connectivity in conjunction with decreased neurite number, PSD95-protein levels and glutamate receptor expression. Gene expression profiles of SCZD hiPSC neurons identified altered expression of many components of the cyclic AMP and WNT signalling pathways. Key cellular and molecular elements of the SCZD phenotype were ameliorated following treatment of SCZD hiPSC neurons with the antipsychotic loxapine. To date, hiPSC neuronal pathology has only been demonstrated in diseases characterized by both the loss of function of a single gene product and rapid disease progression in early childhood. We now report hiPSC neuronal phenotypes and gene expression changes associated with SCZD, a complex genetic psychiatric disorder.