空间两条不相交管路的最短连接的图解和计算

本文用图解对辅助平面法,换面法和旋转法进行分析比较,从中得出简易可行的最佳方法,亚进行解析运算。使空间两条不相交管路的最短连接距离在“形”与“数”两个方面得到较好解决。     

Adjoint approach to VDA of "on-off" processes based on nonlinear perturbation equation

A new adjoint approach is applied to variational data assimilation of a general "on-off" switch model. The accurate gradient expression is obtained in analytical case. In discrete case, the existence of gradient is discussed in three types of difference schemes, and the corresponding adjoint equations are derived. The advantage of the new approach in real application is shown by numerical experiment: not only it can lead optimization to converge to global minimum, but also the assimilation system built by conventional approach can still be used.     

弹簧支承减速器提升机的振动特性及影响它的因素

本文对JKM(Ⅰ)型多绳提升机的几个机型的振动特性及其影响因素进行了理论分析和实验研究,指出了该类型机器在生产运行中出现强烈振动的原因,提出了改进措施。对某矿主井提升机进行了具体分析,找到了症结所在,所得结论可用于对现场使用的JKM(Ⅰ)型提升机的消振。     

转动惯量与动力矩转移——几个体操动作的力学分析

本文阐述了转动惯量和动力矩转移原理,并以此分析了六个体操动作,解决了一些体操技术教学训练中的难点     

N1923串级萃取分离La、Nd数学模拟

在较宽的酸度、稀土浓度、不同体系条件下探讨了N_(1923)萃取La、Nd的性能,详细地研究了在HNO_3介质中料液中酸度[H~+]_F、镧、钕浓度[La~(3+)]_F、[Nd~(3+)]_F对萃取平衡的影响规律,绘制了La、Nd萃取平衡等温线和分配比例数D~(-1)与平衡水相中镧总浓度[La~(3+)]_a,镧、钕萃取率E％与料液中酸度[H~+]_F关系图等,设计了计算程序用计算机进行数学模拟。并用N_(1923)进行串级萃取分离La、Nd,获得了纯度为99％以上的La、Nd产品,模拟式合理,萃取分离效果好。     

A microRNA polycistron as a potential human oncogene

To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.     

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

TRF2 is a telomere-binding protein that has a role in telomere protection. We generated mice that overexpress TRF2 in the skin. These mice had a severe phenotype in the skin in response to light, consisting of premature skin deterioration, hyperpigmentation and increased skin cancer, which resembles the human syndrome xeroderma pigmentosum. Keratinocytes from these mice were hypersensitive to ultraviolet irradiation and DNA crosslinking agents. The skin cells of these mice had marked telomere shortening, loss of the telomeric G-strand overhang and increased chromosomal instability. Telomere loss in these mice was mediated by XPF, a structure-specific nuclease involved in ultraviolet-induced damage repair and mutated in individuals with xeroderma pigmentosum. These findings suggest that TRF2 provides a crucial link between telomere function and ultraviolet-induced damage repair, whose alteration underlies genomic instability, cancer and aging. Finally, we show that a number of human skin tumors have increased expression of TRF2, further highlighting a role for TRF2 in skin cancer.     

鄂博梁Ⅲ号构造上、下油砂山组成岩作用及对孔隙影响

根据砂岩普遍薄片、铸体薄片、扫描电镜和其他化验资料等,系统研究柴达木盆地北缘地区鄂博梁Ⅲ号构造的岩石学特征、成岩作用及对孔隙的影响.结果表明:研究区储集砂岩较细,以细砂岩和粉砂岩为主,含少量中砂岩和粗砂岩;岩石类型主要为长石砂岩和岩屑长石砂岩,含少量长石岩屑砂岩.成岩作用主要为压实作用、胶结作用和溶蚀作用,成岩作用阶段已经达到晚成岩阶段A期.压实作用中等是孔隙度大量丧失的主要原因.胶结作用较强,胶结物主要有碳酸盐胶结物、硫酸盐胶结物、硅质胶结和黏土矿物胶结,胶结物充填孔隙、堵塞喉道,在成岩早期能起骨架支撑缓解压实作用的进行.溶蚀作用中等,主要为长石、岩屑、碳酸盐胶结物及杂基等易溶组分溶蚀成粒间、粒内溶蚀孔,为储层增加次生孔隙,属于建设性成岩作用.     

铝合金表面有色钛/锆转化膜的成膜机理及性能

为了解决工业生产中钛/锆转化膜无色的问题,通过向含钛/锆的处理液中加入单宁酸及成膜促进剂,在铝合金表面制备了有色钛/锆转化膜.采用X射线能谱仪、扫描电镜、傅里叶变换红外光谱仪、X射线衍射仪、X射线光电子能谱仪和电化学工作站对转化膜的形成过程、形貌、组织结构、耐蚀性等进行了分析.结果表明:在铝合金表面成功制备出了金黄色、耐蚀性优异的转化膜,其主要成分是Na3AlF6,其次是单宁酸水解产物的金属络合物以及少量Al2O3.3H2O、TiO2等;膜的形成可分为Na3AlF6晶体成核、生长和金属络合物的沉积3个阶段;转化膜的腐蚀电流密度由基体的5.894μA/cm2下降到0.283μA/cm2,耐蚀性明显提高.     

两台平行机上链约束下单位长度工件完工时间平方和最小的在线排序问题

研究了两台平行机上链约束下单位长度工件完工时间平方和最小的在线排序问题,要求在整数时刻到达工件,整数时刻开始加工工件,当然也会在整数时刻完工工件.利用对手法证明任一实例在任意算法下竞争比不小于5/4,而任意的稠密算法的竞争比都渐近地趋于2;其次找到一种稠密算法—层次算法,其竞争比为2,从而说明此层次算法为本问题的一个最好可能在线稠密算法.