Chronic hepatic injury following experimental viral hepatitis in the dog

Zusammenfassung 20 junge, nicht immune Beagle Hunde (Neutralisationstiter < 1/4) wurden mit 300 ID₅₀ (Gewebskultur) des Hepatitis-canis-Virus infiziert. Alle Tiere starben innerhalb von 4–6 Tagen an ausgedehnter Lebernekrose. Im Gegensatz dazu überlebten 16 partiell immune Tiere (Neutralisationstiter 1/4 bis 1/100) die akute Erkrankung. Im Verlaufe einer Überlebenszeit bis zu 8 Monaten entwickelte sich eine der menschlichen Hepatitis chronica ähnliche Lebererkrankung.     

Fine structure of the gut epithelium ofSchistosoma mansoni

Résumé L'épithélium de l'intestin deSchistosoma mansoni est un syncyte de structure pareille dans les 2 sexes. Des lamelles hérissent la surface et de nombreuses invaginations basales en fentes rayent l'épithélium de la paroi basale plasmique. On constate l'existence d'une digestion extracellulaire, ainsi que l'évidence morphologique d'une utilisation des gouttes lipides entières et des micropinosyncytes. Des procès cytoplasmiques du parenchyme s'attachent par des complexions jonctionnelles («junctional complexes») à la base de l'épithélium de l'intestin et mettent en connection les 2 systèmes. La localisation de l'activité de la phosphatase acide dans les lamelles de la paroi intestinale est précisée.     

Binding bovine immunoglobulins to anterior lobe cells of the hypophysis

Summary Cells of the anterior lobe of the bovine hypophysis, show an affinity for immunoglobulins IgG, IgA and IgM. The phenomenon either provides a message to stimulate cellular secretion or to excite mechanisms associated with the synthesis and release of Ig's or their determinants.This study was supported by a grant from the National Research council of Canada.     

Embryonic chick muscle produces an FGF-like activity

Normal and pathological formation of blood vessels is of considerable interest both in terms of basic scientific processes and clinical applications. Angiogenic events in the adult are likely to represent persistence of developmental mechanisms, and embryos are therefore a suitable experimental model for these processes. Among embryonic tissues, muscle is particularly appropriate for investigation, since it is highly vascularised from early stages. There are a number of competing explanations of how this process is controlled. Bioassays offer advantages over conventional molecular localisation techniques, in that they reveal the presence of active processed forms of the molecules under study, rather than non-processed forms, or non-translated meassages. Using these techniques, we report here that embryonic chick muscle, taken from the stages at which blood vessels are forming, produces an angiogenic activity on the chick chorioallantoic membrane (CAM), and transforms NR6 cells in soft agar. Basic fibroblast growth factor (bFGF) is shown to be angiogenic on the CAM in the same way, and also transforms NR6 cells (NR6 cells lack functional epidermal growth factor/transforming growth factor-a receptors, and are believed to respond only to bFGF in this way). Anti-bFGF removes the transforming activity of the embryonic muscle. We conclude that this represents evidence that embryonic chick muscle is producing an FGF-like molecule which is capable of acting as an angiogenic agent at the appropriate times in development.