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81.
If photographs are taken of moving objects at slow shutter speeds the images of the objects are blurred. In human vision, however, we are not normally conscious of blur from moving objects despite the fact that the temporal response of the photoreceptors is sluggish. It has been suggested that there are motion-deblurring mechanisms specifically to aid the visual system in the analysis of the shape of retinally moving targets. Models of motion deblurring have been influenced by the finding that certain very precise spatial pattern discriminations are unaffected by motion. An example is vernier hyperacuity, in which the observer must detect the direction of offset between two lines with abutting ends. With a stationary stimulus, observers can detect a vernier cue of less than 10 arcsec and acuity is unaffected by retinal-image motion of up to 3 deg s-1 We confirm this finding, but provide evidence against any general deblurring mechanism by showing that another kind of hyperacuity, discrimination of the distance between two parallel lines (spatial interval acuity), is interfered with by motion. This argues against a general deblurring mechanism, such as a neural network 'shifter circuit', and we point out that the high level of vernier acuity for moving stimuli is susceptible to an alternative explanation. 相似文献
82.
加筋土技术的理论研究与工程应用 总被引:5,自引:0,他引:5
概述了加筋技术的概念、应用领域、特点和发展。介绍了国内外加筋机理的理论研究和设计方法,以及在工程中大量采用的加筋挡墙、加筋土坡、加筋土垫层的设计方法和应用特点。 相似文献
83.
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85.
86.
In this paper, we establish that the following fitting problem is NP-hard: given a finite set X and a dissimilarity measure d on X (d is a symmetric function from X
2
to the nonnegative real numbers and vanishing on the diagonal), we wish to find a Robinsonian dissimilarity d
R
on X minimizing the l
∞
-error ||d − d
R
||
∞
= maxx,y
∈X{|d(x, y) − d
R
(x, y)|} between d and d
R
. Recall that a dissimilarity d
R
on X is called monotone (or Robinsonian) if there exists a total order ≺ on X such that x ≺ z ≺ y implies that d(x, y) ≥ max{d(x, z), d(z, y)}. The Robinsonian dissimilarities appear in seriation and clustering problems, in sparse matrix ordering and DNA sequencing. 相似文献
87.
Cell respiration in mitochondria and some bacteria is catalysed by cytochrome c oxidase, which reduces O2 to water, coupled with translocation of four protons across the mitochondrial or bacterial membrane. The enzyme's catalytic cycle consists of a reductive phase, in which the oxidized enzyme receives electrons from cytochrome c, and an oxidative phase, in which the reduced enzyme is oxidized by O2. Previous studies indicated that proton translocation is coupled energetically only to the oxidative phase, but this has been challenged. Here, with the purified enzyme inlaid in liposomes, we report time-resolved measurements of membrane potential, which show that half of the electrical charges due to proton-pumping actually cross the membrane during reduction after a preceding oxidative phase. pH measurements confirm that proton translocation also occurs during reduction, but only when immediately preceded by an oxidative phase. We conclude that all the energy for proton translocation is conserved in the enzyme during its oxidation by O2. One half of it is utilized for proton-pumping during oxidation, but the other half is unlatched for this purpose only during re-reduction of the enzyme. 相似文献
88.
人本主义心理学认为学习者具有发展潜能的能力和动力,研究者应促进其个性发展和潜能发挥;社会认知学派通过所构建的研究框架确定学习自主性程度,采用五个维度描述自主学习状态,认为自主学习能力习得是将外部学习技能内化为个人能力的过程;信息加工理论指出完整意义上的自主学习过程经历四个阶段,还构建了自主学习内在机制;元认知理论认为循序渐进的发展过程直接影响自主性学习能力的发展。对各理论学派教育哲学理念进行全面梳理,利于研究者借鉴其成果,从而提出本土化之理论。 相似文献
89.
Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism. 总被引:11,自引:0,他引:11
Q Waisfisz N V Morgan M Savino J P de Winter C G van Berkel M E Hoatlin L Ianzano R A Gibson F Arwert A Savoia C G Mathew J C Pronk H Joenje 《Nature genetics》1999,22(4):379-383
Somatic mosaicism due to reversion of a pathogenic allele to wild type has been described in several autosomal recessive disorders. The best known mechanism involves intragenic mitotic recombination or gene conversion in compound heterozygous patients, whereby one allele serves to restore the wild-type sequence in the other. Here we document for the first time functional correction of a pathogenic microdeletion, microinsertion and missense mutation in homozygous Fanconi anaemia (FA) patients resulting from compensatory secondary sequence alterations in cis. The frameshift mutation 1615delG in FANCA was compensated by two additional single base-pair deletions (1637delA and 1641delT); another FANCA frameshift mutation, 3559insG, was compensated by 3580insCGCTG; and a missense mutation in FANCC(1749T-->G, Leu496Arg) was altered by 1748C-->T, creating a cysteine codon. Although in all three cases the predicted proteins were different from wild type, their cDNAs complemented the characteristic hypersensitivity of FA cells to crosslinking agents, thus establishing a functional correction to wild type. 相似文献
90.
Epigenetic inheritance at the agouti locus in the mouse. 总被引:21,自引:0,他引:21