交流磁场对Al-Fe合金凝固组织的影响

研究了交流磁场对Al-Fe合金中含铁相形态及分布的影响.近共晶Al-1.99%Fe(质量分数,下同)和亚共晶Al-0.90%Fe两种铝合金在3℃/min的冷却速率凝固过程中,施加强度为0.3 T,频率为20 Hz的交流磁场,并与未施加磁场的试样进行对比.实验结果表明,在这两种合金中,无论是先析出Al3Fe相还是先析出-αAl,施加交流磁场后,Al3Fe相均向试样的中心处富集.这是由于Al3Fe相的磁化率大于熔融铝基体的磁化率,使得Al3Fe相和铝基体相比受到指向样品轴线的更大的电磁力,从而导致其向试样中心处聚集.     

地方综合型院校E-Learning现状与技术展望

随着高等教育日趋大众化和教学改革逐渐向深层次发展,E-Learning已经成为教育现代化发展的一个主要方向.实施E-Learning,可以缓解扩招与教学资源相对短缺的矛盾,有利于教学资源的优化配置,提高办学效益;也有利于推动教学方法、手段的改革和教学质量的提高.但地方综合院校的E-Learning层次尚待提高,技术还须完善,观念还需加强.     

高职教育集约化发展的成因及效应分析

近几年，高职教育迅速发展，但教育资源相对短缺且利用效率低下的矛盾日益突出，对此，有必要从体制变革和制度创新的视角，借鉴我国企业改革的成功经验，通过集约化办学合理配置和充分利用教育资源。这是在一定范围内实现资源共享，降低办学成本，提高办学效率，促进校企深度合作和工学结合的有效途径。     

A chemical switch for inhibitor-sensitive alleles of any protein kinase

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts to assign specific signalling roles to individual kinases. Here we describe a chemical genetic strategy for sensitizing protein kinases to cell-permeable molecules that do not inhibit wild-type kinases. From two inhibitor scaffolds, we have identified potent and selective inhibitors for sensitized kinases from five distinct subfamilies. Tyrosine and serine/threonine kinases are equally amenable to this approach. We have analysed a budding yeast strain carrying an inhibitor-sensitive form of the cyclin-dependent kinase Cdc28 (CDK1) in place of the wild-type protein. Specific inhibition of Cdc28 in vivo caused a pre-mitotic cell-cycle arrest that is distinct from the G1 arrest typically observed in temperature-sensitive cdc28 mutants. The mutation that confers inhibitor-sensitivity is easily identifiable from primary sequence alignments. Thus, this approach can be used to systematically generate conditional alleles of protein kinases, allowing for rapid functional characterization of members of this important gene family.     

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates. Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the A beta-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia.     

积水和降雨下非饱和重塑黄土水分入渗模拟

为合理预测积水和降雨情况下非饱和重塑黄土水分迁移过程,在已有模型基础上,提出了能合理考虑浸润锋处吸力作用和水分剖面形状的改进模型,并给出了该模型计算方法以及求解Richard方程数值方法所需渗透参数的可靠确定方法.研究结果表明:与已有模型相比,改进模型能更准确地预测室内一维非饱和重塑黄土土柱积水入渗试验中浸润锋迁移过程和各测点水分变化过程;采用改进浸润锋前进法获得的非饱和渗透系数函数,比采用根据室内饱和渗透试验和持水曲线间接获得的参数所得预测结果更为准确;降雨分析中,改进模型得到径流发生后的水分剖面基本接近于数值方法分析结果,特别是在试样干密度比较大的情况.