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Résumé L'acide-amino-butyrique et la-alanine reproduisent l'action du transmetteur inhibiteur du système neuromusculaire de l'écrevisse. Ces deux acids aminés diminuent la contraction musculaire. L'acide-amino-butyrique réduit la différence de potentiel et augmente sa décomposition. L'action de ces acides aminés est bloquée par la picrotoxine comme l'est celle du transmetteur inhibiteur.
The study was supported by Grants B-1089 and B-31 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service. Some of this work was done at the Department of Zoology, Cornell University. We are grateful to Prof.S. C. Wang, Columbia University, for generous assistance. 相似文献
The study was supported by Grants B-1089 and B-31 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service. Some of this work was done at the Department of Zoology, Cornell University. We are grateful to Prof.S. C. Wang, Columbia University, for generous assistance. 相似文献
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The PI-linked receptor FcRIII is released on stimulation of neutrophils 总被引:41,自引:0,他引:41
T W Huizinga C E van der Schoot C Jost R Klaassen M Kleijer A E von dem Borne D Roos P A Tetteroo 《Nature》1988,333(6174):667-669
Human phagocytic cells express receptors for the constant (Fc) region of immunoglobulin G. Neutrophils carry Fc receptor II (FcRII; CDw32) and FcRIII (CD16) which both bind IgG-containing immune complexes, leading to phagocytosis of the complex and activation of the neutrophil. We find that patients with paroxysmal nocturnal haemoglobinuria (PNH) have only about 10% of the normal levels of FcRIII on their neutrophils, whereas the expression of FcRII is unaffected. We show that FcRIII is a phosphatidyl inositol (PI)-anchored protein in neutrophils. Analysis of FcRIII expression in cells of PNH patients, known to be deficient in PI-linked proteins, suggests FcRIII is not PI-linked in monocytes. We find that the synthesis of FcRIII in neutrophils from PNH patients appears normal, indicating that the defect lies in the PI linkage. This lipid linkage of the receptor on neutrophils suggests that its release may be important for its function, and indeed FcRIII release was observed on stimulation of neutrophils by an inflammatory bacterial peptide (f-Met-Leu-Phe), suggesting a role for FcRIII shedding in inflammatory reactions. Activation of the PNH neutrophils with IgG-coated latex beads appeared normal (although binding of dimer IgG complexes was reduced), indicating that FcRII, rather than FcRIII, is involved in neutrophil stimulation. 相似文献
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Homologous plant and bacterial proteins chaperone oligomeric protein assembly 总被引:190,自引:0,他引:190
S M Hemmingsen C Woolford S M van der Vies K Tilly D T Dennis C P Georgopoulos R W Hendrix R J Ellis 《Nature》1988,333(6171):330-334
An abundant chloroplast protein is implicated in the assembly of the oligomeric enzyme ribulose bisphosphate carboxylase-oxygenase, which catalyses photosynthetic CO2-fixation in higher plants. The product of the Escherichia coli groEL gene is essential for cell viability and is required for the assembly of bacteriophage capsids. Sequencing of the groEL gene and the complementary cDNA encoding the chloroplast protein has revealed that these proteins are evolutionary homologues which we term 'chaperonins'. Chaperonins comprise a class of molecular chaperones that are found in chloroplasts, mitochondria and prokaryotes. Assisted post-translational assembly of oligomeric protein structures is emerging as a general cellular phenomenon. 相似文献
216.
本书介绍了Turbo码在不同应用(并行卷积Turbo码、分组Turbo码)中的基础知识。作者通过一些将数据传输和存储作为主要优化因素的系统设计方法,展示了如何用Turbo码实现提升吞吐量、延迟和能量消耗方面的性能。这些方法和结果可以使Turbo码成为传统卷积码和代数码的替代者。书的最后还给出了一个并行卷积Turbo码的ASIC数据流实现。 相似文献
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