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排序方式: 共有155条查询结果,搜索用时 15 毫秒
81.
82.
D. C. Sharma P. S. Davis P. K. Sharma 《Cellular and molecular life sciences : CMLS》1982,38(5):565-567
Summary Ascorbic acid mediated a small but significant degradation of methylmercury to inorganic mercury in goldfish (Carassius auratus) and reduced the toxicity of mercuric chloride despite its substantial conversion into organic form.
This investigation was supported by a grant from the Fishing Industry Research Account of the Australian Department of Primary
Industry. 相似文献
83.
84.
Zusammenfassung Die mutagene Wirkung von Aethylenmethansulfonat inDrosophila-Männchen wird durch DMSO um 46% erhöht. DMSO allein kann keine Mutation über die Spontanrate hinaus induzieren. 相似文献
85.
S. S. Sharma 《Cellular and molecular life sciences : CMLS》1985,41(1):45-46
Summary Mercuric acetate, at 5.0×10–5 M, stimulates the mobilization of total nitrogen and phosphate reserves from cotyledons during seedling growth inCicer arietinum cv H208 whereas it suppresses the same process at 2.5×10–4 M.Thanks are due to Dr D. Banerji for providing facilities and helpful suggestions. 相似文献
86.
87.
J M Sharma 《Nature》1974,247(436):117-118
88.
Many lines of evidence indicate that genetically distinct subtypes of motor neurons are specified during development, with each type having characteristic properties of axon guidance and cell-body migration. Motor neuron subtypes express unique combinations of LIM-type homeodomain factors that may act as intrinsic genetic regulators of the cytoskeletal events that mediate cell migration, axon navigation or both. Although experimentally displaced motor neurons can pioneer new routes to their targets, in many cases the axons of motor neurons in complete isolation from their normal territories passively follow stereotypical pathways dictated by the environment. To investigate the nonspecific versus genetically controlled regulation of motor connectivity we forced all motor neurons to express ectopically a LIM gene combination appropriate for the subgroup that innervates axial muscles. Here we show that this genetic alteration is sufficient to convert the cell body settling pattern, gene-expression profile and axonal projections of all motor neurons to that of the axial subclass. Nevertheless, elevated occupancy of the axial pathway can override their genetic program, causing some axons to project to alternative targets. 相似文献
89.
Vanesa Lafarga Olga Tapia Sahil Sharma Rocio Bengoechea Georg Stoecklin Miguel Lafarga Maria T. Berciano 《Cellular and molecular life sciences : CMLS》2018,75(3):527-546
The survival of motor neuron (SMN) protein plays an essential role in the biogenesis of spliceosomal snRNPs and the molecular assembly of Cajal bodies (CBs). Deletion of or mutations in the SMN1 gene cause spinal muscular atrophy (SMA) with degeneration and loss of motor neurons. Reduced SMN levels in SMA lead to deficient snRNP biogenesis with consequent splicing pathology. Here, we demonstrate that SMN is a novel and specific target of the acetyltransferase CBP (CREB-binding protein). Furthermore, we identify lysine (K) 119 as the main acetylation site in SMN. Importantly, SMN acetylation enhances its cytoplasmic localization, causes depletion of CBs, and reduces the accumulation of snRNPs in nuclear speckles. In contrast, the acetylation-deficient SMNK119R mutant promotes formation of CBs and a novel category of promyelocytic leukemia (PML) bodies enriched in this protein. Acetylation increases the half-life of SMN protein, reduces its cytoplasmic diffusion rate and modifies its interactome. Hence, SMN acetylation leads to its dysfunction, which explains the ineffectiveness of HDAC (histone deacetylases) inhibitors in SMA therapy despite their potential to increase SMN levels. 相似文献
90.
P. Laxman Mani Kanta V. C. Srivastava K. Venkateswarlu Sharma Paswan B. Mahato Goutam Das K. Sivaprasad K. Gopala Krishna 《矿物冶金与材料学报》2017,24(11):1293-1305
The objectives of this study were to produce ultrafine-grained (UFG) AA2024 aluminum alloy by cryorolling followed by aging and to evaluate its corrosion behavior. Solutionized samples were cryorolled to ~85% reduction in thickness. Subsequent aging resulted in a UFG structure with finer precipitates of Al2CuMg in the cryorolled alloy. The (1) solutionized and (2) solutionized and cryorolled samples were uniformly aged at 160℃/24 h and were designated as CGPA and CRPA, respectively; these samples were subsequently subjected to corrosion studies. Potentiodynamic polarization studies in 3.5wt% NaCl solution indicated an increase in corrosion potential and a decrease in corrosion current density for CRPA compared to CGPA. In the case of CRPA, electrochemical impedance spectroscopic studies indicated the presence of two complex passive oxide layers with a higher charge transfer resistance and lower mass loss during intergranular corrosion tests. The improved corrosion resistance of CRPA was mainly attributed to its UFG structure, uniform distribution of fine precipitates, and absence of coarse grain-boundary precipitation and associated precipitate-free zones as compared with the CGPA alloy. 相似文献