MATLAB软件在电路设计中的应用

目前在电路设计中，功能验证遇到两方面困难．首先，利用手工输入测试向量的方法不能满足测试需求；其次，观测波形文件的方法不仅费时而且容易出错．本文针对在电路设计过程中所遇到的这两方面困难，以一个有限冲击响应（Finite Impulse Response，FIR）数字滤波器的设计为例．提出引入MATLAB软件进行辅助电路设计的方法．利用MATLAB软件进行电路参数确定，辅助产生电路的仿真测试向量及预期结果，并实现电路仿真结果的自动分析比较．该方法能够灵活地生成大量复杂的测试向量，减轻电路设计者的工作量，节约仿真验证时间，保证电路设计的正确性．     

TPA诱导肝癌细胞SMMC7721凋亡及与RXRα和TR3的关系

 在肝癌细胞SMMC7721中研究TPA诱导的凋亡及它与细胞核受体TR3和RXRα的关系.实验中使用SMMC7721肝癌细胞.用MTT法检测生长抑制.用DAPI荧光染色法观察凋亡形态,随机记数1 000个细胞以计算凋亡指数.用CAT分析检测RXRα转录活性的抑制.用Western Blot检测RXRα蛋白的表达水平.用RT-PCR检测TR3 mRNA的表达水平.用MTT检测到TPA对SMMC7721肝癌细胞的生长抑制,并且有剂量依赖性.TPA诱导SMMC7721肝癌细胞的凋亡,RXRα蛋白随时间依赖性的降解,并且用CAT分析检测到TPA能抑制RXRα的转录活性.另外TPA能诱导TR3 mRNA的表达上调.TPA抑制SMMC7721肝癌细胞的生长,并诱导凋亡.TPA能上调TR3的mRNA,使RXRα随时间依赖性的降解,并能抑制RXRα的转录活性.因此TPA诱导SMMC7721肝癌细胞的凋亡可能与细胞核受体TR3和RXRα有某些联系.     

基于小波变换和混合神经网络的图像压缩算法

提出了一种将空间方向小波零树编码与混合神经网络相结合，新的多尺度系数矢量量化策略．该算法在对图像进行多级小波变换后，利用3个方向上各自小波系数之间的相关性，构造符合图像特征的跨频带矢量，依据矢量能量和零树矢量的思想进行矢量分类，分别利用主元分析和自组织特征映射神经网络对3个方向的多尺度系数矢量进行基于视觉的加权矢量量化压缩编码．仿真实验结果表明该算法是合理可行的．     

Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene

Hemagglutinin-neuramidinase (HN), a Newcastle disease virus-derived protein, not only mediates receptor recognition but also possesses neuraminidase (NA) activity, the ability to cleave a component of those receptors, N-acetylneuraminic acid (NAcneu, sialic acid). It is known that this protein in mammalian species, including human beings, has interesting anti-neoplastic as well as immune stimulating properties. To explore the use of the HN gene in cancer gene therapy, we constructed a recombi-nant fowlpox virus expressing the HN protein (vFV-HN) and compared the anti-tumor activity of the recombinant virus with that of wild-type fowlpox virus (FPV) in vivo and in vitro. Here we found that although B16 cells were somewhat resistant to the basal cytotoxic effect of wild-type fowlpox virus, infection with vFV-HN caused a pronounced cytotoxic effect and, the survival of tumor-bearing mice immunized with vFV-HN was significantly increased compared with the survival of mice immunized with the FPV alone. Furthermore, the immunization of mice with vFV-HN elicited a B16 tumor-specific cytotoxic T lymphocyte (CTL) response and clonal expansion of both CD4 and CD8 T cell populations in vivo. In addition, T cells from lymph nodes of mice vaccinated with vFV-HN secreted high levels of the Th1 cytokine IL-2 and IFN-γ, indicating that the regression of tumor cells is related to a Th1-type dominant immune response. These results demonstrate that vaccination with vFV-HN may be a potential strategy for cancer gene therapy.     

Late Mesozoic metamorphic core complexes: new constraints on lithosphere thinning in North China

Metamorphic core complexes (mcc’s) are among the most prominent structural styles of lithosphere extension and thinning during late Mesozoic in North China. In this paper, the geometrical, kinematic and age characteristics of some of the mcc’s, e.g. Liaonan, Waziyu (Yiwulüshan), Yunmengshan, etc., are discussed. Some common characteristics, such as kinematic polarity, geometric asymmetry, occurrence over a time span, scattered and isolated distribution, and progressive development, can provide direct constraints on the regional lithosphere extension and thinning in North China, which does not favor the prevailing plume model，a general delamination model or extensional collapse of overthickened orogenic crust. We argue that several aspects, such as the kinematic polarity at depths during lithosphere extension, gradual break-up of lithosphere plate, relationship between magmatism and regional extension, and coeval activity of mcc’s and Tan Lu fault, should be taken into consideration when constructing a more reasonable model for lithosphere extension and thinning in North China.     

Application of Nanometer-Size Titanium Dioxide in Extreme-Trace V（Ⅴ） Analysis

0Introduction Vanadiumplaysanimportantroleinmodernindustry,es peciallyinsteelandchemicalindustry.Forinstance,itscompoundsarewidelyappliedintheproceduresofvitrioland petroleumchemicalmanufactureascatalyzers[14].Vanadium hasseveralvalences,butgenerallyitslowvalencesturnintohighoneseasilyinenvironment[5].BecauseV(Ⅴ)isthemost stableandpoisonousone,weoftenlayemphasisonitinenvi ronmentalpollutioncontrol.Vanadiumexistsinenvironmentalwaterwithextremelylowconcentration.Inseawateritscontentislessthan…     

高等院校“双语教学”的探讨

针对目前在教育界双语教学炒作过热,本文从师资、学生素质、英语环境、教材以及财力和设备等几个方面指出高等院校真正实施双语教学还存在着很多不足,并对现阶段高等院校“双语教学”的教学活动进行了认真的探讨。     

甲醇液相氧化羰化合成碳酸二甲酯动力学研究

研究了不同Schiff碱配合CuCl对甲醇液相氧化羰化合碳酸二甲酯反应的影响，得到了Schiff碱与CuCl复合催化体系的动力学方程，通过对实验数据的处理，得到了相关动力学参数，研究结果表明，当催化剂的浓度为0.2mol/L，Schiff碱与CuCl的量满足cSchiff base/cCuCL=2:1的条件，反应温度为120℃，反应压力为2.4MPa,CO与O2的进气摩尔比为2：1时，phen/CuCl复合催化体系的反应速率最快，其动力学方程为－dpCO/dt=0.216p^1.10PCO,活化能为44．31kJ/mol.     

基于等价关系的关联规则的挖掘

由于在实际的数据挖掘过程中容易出现无用的频集和冗余的规则，所以降低频集和规则的冗余度可大大提高挖掘的质量，这也是数据挖掘中一直被关注的问题，提出了一个用等价类生成关联规则的方法，算法主要在频集的基础上建立项集的等价关系，进而对项集划分等价类，同时将得到的关联规则划分为精确关联规则和近似关联规则两个集合，通过等价类，不但可以很容易地生成所需要的关系规则，同时可以方便地判断数据之间依赖关系的强弱，同时，项集的等价关系在实际应用中也很有利用价值，算法最后的规则结果集剔除了由来自同一等价类中的面集的重复出现构成的冗余规则，从而得到了较小的关联规则集合。     

A genetic algorithm on multiple sequences alignment problems in biology

The study and comparison of sequences of characters from a finite alphabet is relevant to various areas of science, notably molecular biology. The measurement of sequence similarity involves the consideration of the possible sequence alignments in order to find an optimal one for which the “distance” between sequences is minimum. In biology informatics area, it is a more important and difficult problem due to the long length (100 at least) of sequence, this cause the compute complexity and large memory require. By associating a path in a lattice to each alignment, a geometric insight can be brought into the problem of finding an optimal alignment, this give an obvious encoding of each path. This problem can be solved by applying genetic algorithm, which is more efficient than dynamic programming and hidden Markov model using commomly now. Foundation item: Supported by Zi-qiang Foundation of Wuhan University and Open Foundation of the State Key-Laboratory of Software Engineering, Wuhan University Biography: Shi Feng(1966-), male, Associate professor, research direction: bioinformatics.