The NCBI dbGaP database of genotypes and phenotypes

The National Center for Biotechnology Information has created the dbGaP public repository for individual-level phenotype, exposure, genotype and sequence data and the associations between them. dbGaP assigns stable, unique identifiers to studies and subsets of information from those studies, including documents, individual phenotypic variables, tables of trait data, sets of genotype data, computed phenotype-genotype associations, and groups of study subjects who have given similar consents for use of their data.     

Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease

Camurati-Engelmann disease (CED; MIM 131300), or progressive diaphyseal dysplasia, is a rare, sclerosing bone dysplasia inherited in an autosomal dominant manner. Recently, the gene causing CED has been assigned to the chromosomal region 19q13 (refs 1-3). Because this region contains the gene encoding transforming growth factor-beta 1 (TGFB1), an important mediator of bone remodelling, we evaluated TGFB1 as a candidate gene for causing CED.     

电磁驻波摆动器自由电子激光的小信号增益

利用 Madey's theorem计算了电磁驻波摆动器的自由电子激光的小信号增益 .结果表明它与普通静磁摆器自由电子激光的增益具有相似表达形式 .     

析取置信规则库系统参数优化的深度神经网络模型

基于深度学习的置信规则库系统在参数优化方面存在可移植性差、应用效率低等问题,为此,将深度神经网络与析取置信规则库结合,有效减少模型的规则和参数的数量;引入梯度下降算法优化模型参数,提高模型构建和优化的效率. 通过非线性函数拟合、北京市空气质量污染预测和多个UCI公共分类数据集的实验,对提出的方法进行验证,并将实验结果与现有的置信规则库系统和传统的机器学习方法进行对比. 结果表明,所提出的方法比传统的方法具有更高的推理精度和更快的训练速度.     

鲁棒性多腔窄带滤光片的自动优化设计

将膜系容差纳入评价函数，提出了多腔窄带激光片鲁棒性设计的概念和方法。阐述了理论分析的依据，在修改的程序基础上得出一组优化设计的膜系。结果表明这种方法得到的膜系不一定是最优的理论解，但一定是最优的实际解。膜厚灵敏度因子计算结果表明，鲁棒性膜系较其他膜系的敏感度因子要低，从而验证鲁棒设计结果的正确性。     

Genetic analysis and gene fine mapping for a rice novel mutant （rl9〈t）） with rolling leaf character

Much attention has been paid to leaf shape of rice in the process of ideotype breeding[1]. Several authors have reported that the rolling of leaf in some degree helps keep it erect, consequently optimizing canopy light transmission condition, which is good for dry matter accumulation and for high yield[2―6]. Rice as a polymorphic crop has many types of vari- ety with different morphologies. In terms of leaf shape, different cultivars with rolling leaf have been identifiedin rice germplasm. Le…     

Fine mapping and cloning of MT1,a novel allele of D10

Rice tillering is an important determinant for grain production.To investigate the mechanism of tillering,we characterized a multiple tillering mutant (mt1) identified from the japonica variety,Zhonghua 11,treated with EMS.This mutant exhibits advanced tillering development and dwarfed compared with wild-type plants.Genetic analysis and fine gene mapping indicated that the mt1 mutant was controlled by a recessive gene,residing on a 29-kb window on AP003376 of chromosome 1.One putative gene in this region,encoding a carotenoid cleavage dioxygenase 8 (CCD8),was allelic to D10.The mt1 mutant phenotype was complemented by introduction of wild-type MT1,and knockdown of MT1 in wild-type rice mimicked the mutant phenotype.Real-time PCR analysis indicated that the MT1 gene is expressed highly in stems and at a low level in axillary buds,panicles,leaves,and roots.In addition,MT1 expression is clearly under feedback regulation.     

曳引电梯部件故障相关性分析

针对电梯部件之间的故障影响,提出了将决策试验与评价实验室法与解释结构模型结合建立电梯部件故障层次结构模型,并改进直接影响矩阵的确定方式。首先从多方面获取电梯部件故障关联评价,其次使用熵权法确定评价的权重并计算直接影响矩阵,最后使用建立的电梯部件故障相关模型得到电梯部件故障因果关系和故障传递规则。结果表明:电动机、制动器、限速器为强原因部件,曳引钢丝绳、轿厢以及导向系统的部件为强结果部件;电梯部件故障关联规则体现为同层级或跨层级传递。通过分析部件故障机理,所提方法得到的部件故障传递规则与电梯系统实际运行情况相符。     

中国页岩气田地面工程技术研究进展

目前我国页岩气地面工程建设仍处于初级阶段,其关键地面工程技术不成熟。本文阐明了我国页岩气资源的分布、储量情况及开发特点,探析了我国页岩气地面工程技术的显著特点,综述了集输管网布局优化、集输与处理工艺、生产后期增压工艺、撬装化设备设计以及集输管道内腐蚀防控工艺等方面的研究成果和应用现状。同时也展望了我国页岩气地面工程技术逐步朝标准化设计、模块化建设、数字化运维、一体化集成和工艺技术创新等方向发展的总体趋势。     

加速分形块编码

在分形块编码中，值域块与定义块池中的定义域块逐一匹配过程极其费时，为了大大地缩短分形编码的时间，将定义域块和值域块的匹配限制在以值域块的均值和方差作为中心的动态窗口中．动态窗口的长和宽，根据定义域块均值和方差的二维直方图自适应确定．与全局匹配分形块编码相比，大大地缩短了编码时间．