排序方式: 共有22条查询结果,搜索用时 15 毫秒
11.
Complete protein sequence and identification of structural domains of human apolipoprotein B 总被引:45,自引:0,他引:45
T J Knott R J Pease L M Powell S C Wallis S C Rall T L Innerarity B Blackhart W H Taylor Y Marcel R Milne 《Nature》1986,323(6090):734-738
Epidemiological, pathological and genetic studies show a strong positive correlation between elevated plasma concentrations of low-density lipoprotein (LDL) cholesterol and the risk of premature coronary heart disease. Apolipoprotein (apo) B-100 is the sole protein component of LDL and is the ligand responsible for the receptor-mediated uptake and clearance of LDL from the circulation. Apo B-100 is made by the liver and is essential for the assembly of triglyceride-rich very low-density lipoproteins (VLDL) in the cisternae of the endoplasmic reticulum and for their secretion into the plasma. VLDL transports triglyceride to peripheral muscle and adipose tissue, where the triglyceride is hydrolysed by lipoprotein lipase. The resultant particle, relatively enriched in cholesteryl ester, constitutes LDL. LDL delivers cholesterol to peripheral tissues where it is used for membrane and steroid hormone biosynthesis and to the liver, the only organ which can catabolize and excrete cholesterol. Plasma LDL levels are therefore determined by the balance between their rate of production from VLDL and clearance by the hepatic LDL (apo B/E) receptor pathway. Here we report the complete 4,563-amino-acid sequence of apo B-100 precursor (relative molecular mass (Mr) 514,000 (514K] determined from complementary DNA clones. Numerous lipid-binding structures are distributed throughout the extraordinary length of apo B-100 and must underlie its special functions as a nucleus for lipoprotein assembly and maintenance of plasma lipoprotein integrity. A domain enriched in basic amino-acid residues has been identified as important for the cellular uptake of cholesterol by the LDL receptor pathway. 相似文献
12.
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling 总被引:1,自引:0,他引:1
13.
Initial sequencing and analysis of the human genome 总被引:11,自引:0,他引:11
Lander ES Linton LM Birren B Nusbaum C Zody MC Baldwin J Devon K Dewar K Doyle M FitzHugh W Funke R Gage D Harris K Heaford A Howland J Kann L Lehoczky J LeVine R McEwan P McKernan K Meldrim J Mesirov JP Miranda C Morris W Naylor J Raymond C Rosetti M Santos R Sheridan A Sougnez C Stange-Thomann N Stojanovic N Subramanian A Wyman D Rogers J Sulston J Ainscough R Beck S Bentley D Burton J Clee C Carter N Coulson A Deadman R Deloukas P Dunham A Dunham I Durbin R French L Grafham D Gregory S 《Nature》2001,409(6822):860-921
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence. 相似文献
14.
Mungall AJ Palmer SA Sims SK Edwards CA Ashurst JL Wilming L Jones MC Horton R Hunt SE Scott CE Gilbert JG Clamp ME Bethel G Milne S Ainscough R Almeida JP Ambrose KD Andrews TD Ashwell RI Babbage AK Bagguley CL Bailey J Banerjee R Barker DJ Barlow KF Bates K Beare DM Beasley H Beasley O Bird CP Blakey S Bray-Allen S Brook J Brown AJ Brown JY Burford DC Burrill W Burton J Carder C Carter NP Chapman JC Clark SY Clark G Clee CM Clegg S Cobley V Collier RE Collins JE Colman LK Corby NR Coville GJ 《Nature》2003,425(6960):805-811
15.
Climate varied enormously over the most recent ice age--for example, large pulses of ice-rafted debris, originating mainly from the Labrador Sea, were deposited into the North Atlantic at roughly 7,000-year intervals, with global climatic implications. Here we show that ocean tides within the Labrador Sea were exceptionally large over the period spanning these huge, abrupt ice movements, which are known as Heinrich events. We propose that tides played a catalytic role in liberating iceberg armadas during that time. 相似文献
16.
Soderberg AM Berger E Page KL Schady P Parrent J Pooley D Wang XY Ofek EO Cucchiara A Rau A Waxman E Simon JD Bock DC Milne PA Page MJ Barentine JC Barthelmy SD Beardmore AP Bietenholz MF Brown P Burrows A Burrows DN Bryngelson G Byrngelson G Cenko SB Chandra P Cummings JR Fox DB Gal-Yam A Gehrels N Immler S Kasliwal M Kong AK Krimm HA Kulkarni SR Maccarone TJ Mészáros P Nakar E O'Brien PT Overzier RA de Pasquale M Racusin J Rea N York DG 《Nature》2008,453(7194):469-474
Massive stars end their short lives in spectacular explosions--supernovae--that synthesize new elements and drive galaxy evolution. Historically, supernovae were discovered mainly through their 'delayed' optical light (some days after the burst of neutrinos that marks the actual event), preventing observations in the first moments following the explosion. As a result, the progenitors of some supernovae and the events leading up to their violent demise remain intensely debated. Here we report the serendipitous discovery of a supernova at the time of the explosion, marked by an extremely luminous X-ray outburst. We attribute the outburst to the 'break-out' of the supernova shock wave from the progenitor star, and show that the inferred rate of such events agrees with that of all core-collapse supernovae. We predict that future wide-field X-ray surveys will catch each year hundreds of supernovae in the act of exploding. 相似文献
17.
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange 总被引:3,自引:0,他引:3
Liu Y Dentin R Chen D Hedrick S Ravnskjaer K Schenk S Milne J Meyers DJ Cole P Yates J Olefsky J Guarente L Montminy M 《Nature》2008,456(7219):269-273
18.
潘江 《科技情报开发与经济》2004,14(6):9-10
引入研究型大学及其图书馆的定义,阐述了研究型大学图书馆进行人力资源管理的重要意义。进而提出了研究型大学图书馆人力资源管理的策略,包括改变人力资源管理理念,建立以人为本的人才管理机制,注重人才的使用和培养,充分调动馆员的积极性等。 相似文献
19.
庞晓青 《科技情报开发与经济》2004,14(6):250-251
人才是提高综合国力的关键要素。为用好人才,一是要辨证地把握好识别人才、起用人才的标准,既要选拔出德才兼备的人才,又不可求全责备;二是用人要讲究方法。做到公平竞争、择优录用、知人善用,同时鼓励人才合理流动;三是用人要遵循讲正气、讲民主、讲大度的原则,大胆使用人才。 相似文献
20.