CsI高压超导电性的第一性原理

利用基于密度泛函理论的赝势平面波方法计算了高压下CsI的电子能带结构、 电子态密度、 声子谱、 声子态密度以及电子和声子的相互作用, 探讨了CsI在高压下产生超导电性的物理机制. 研究表明, CsI层内的光学振动模式与电子之间的强耦合作用是CsI产生超导电性的主要原因.     

On-Line Scheduling with Rejection on Identical Parallel Machines

In this paper, we consider the on-line scheduling of unit time jobs with rejection on rn identical parallel machines. The objective is to minimize the total completion time of the accepted jobs plus the total penalty of the rejected jobs. We give an on-line algorithm for the problem with competitive ratio 1/2 （2 ＋√3） ≈ 1.86602.     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration

RNA exosomes are multi-subunit complexes conserved throughout evolution and are emerging as the major cellular machinery for processing, surveillance and turnover of a diverse spectrum of coding and noncoding RNA substrates essential for viability. By exome sequencing, we discovered recessive mutations in EXOSC3 (encoding exosome component 3) in four siblings with infantile spinal motor neuron disease, cerebellar atrophy, progressive microcephaly and profound global developmental delay, consistent with pontocerebellar hypoplasia type 1 (PCH1; MIM 607596). We identified mutations in EXOSC3 in an additional 8 of 12 families with PCH1. Morpholino knockdown of exosc3 in zebrafish embryos caused embryonic maldevelopment, resulting in small brain size and poor motility, reminiscent of human clinical features, and these defects were largely rescued by co-injection with wild-type but not mutant exosc3 mRNA. These findings represent the first example of an RNA exosome core component gene that is responsible for a human disease and further implicate dysregulation of RNA processing in cerebellar and spinal motor neuron maldevelopment and degeneration.     

发动机振动主动控制用电磁作动器的设计和动态特性研究

对一种适用于汽车发动机振动主动控制用的新型串接式高能电磁作动器进行了结构设计,计算了作动器的磁场,对作动器的片状弹簧的应力分布进行了有限元分析。同时,建立了作动器的力学模型,对其动态特性进行了仿真分析和试验研究,结果表明作动器是理想的激振源和主动控制用作动器。     

高等数学课程设置的多样化研究

由于专业和学生之间存在差异,在高等数学课程设置上必须实行多样化。具体说来,把高等数学的学习内容分为三个模块:基础模块、拓展模块(基地班)和应用模块,实践表明,这种多样化的高等数学课程设置取得了较好的教学效果。     

具有较小最大度的临界图边数的下界

运用Discharge法给出了不含2点和3点的6临界图及不含4点和5点的7临界图边数的下界．     

国内高校人才培养模式发展趋势研究

从人才培养模式的定义出发,介绍了国内高校传统人才培养模式,总结了我国高校人才培养模式的发展趋势,认为不同的学校要根据自身的实际情况,结合社会需求构建科学的人才培养模式,形成自身的办学特色。     

省级实验示范中心在高校人才培养中的作用

对高校而言,实验教学是理论教学以及科研的基石,是深化理论知识,将间接经验与直接经验相结合的桥梁。论文结合安徽医科大学基础医学院病原与免疫学实验室的成长历程,阐述了省级实验示范中心在高校人才培养中的积极作用,体现在省级实验示范中心建设的引领下,实验中心本着提高实验教学水平和人才培养质量为目标,逐步实现提高实验室建设和管理水平,充分发挥实验示范中心的示范引领作用,以期全面提高高校的实验教学水平,并为高校进一步的实验教学改革创造条件。     

成年男性血小板正常参考值与地理环境的关系

为了给制定中国成年男性血小板正常参考值的统一标准提供科学依据,收集了中国100个单位测定的12670例成年男性血小板正常参考值,应用SPSS统计软件,运用相关分析和回归分析的方法,研究了其与7项地理因素指标的关系。