重庆市中小学教师队伍建设问题与对策

中小学教师队伍建设在重庆教育发展中举足轻重,目前在总体数量上已基本能满足需要,然而在队伍结构等许多方面还存在比较突出的问题。只有切实认清各种现实问题,并积极探寻有效对策,才能有力促成重庆中小学教师队伍的均衡、有序、持续、健康的发展,进而为实现长江上游的教育中心和西部地区教育高地的宏伟目标提供保障。     

大型锻造液压机全预紧机架的整体性分析

用三维有限元接触计算方法分析了大型锻造液压机全预紧机架的整体工作性能，较为确切地计算了各部件的变形及彼此间的接触内力分布，并给出了梁-柱结合面缝隙的具体形态。在此基础上确定了预紧参数。     

中国中老年男性红细胞压积参考值与海拔高度的关系

为制定中国中老年男性红细胞压积参考值的统一标准提供科学依据，收集了中国各地用温氏法测定的健康中老年男性红细胞压积参考值，并对其与海拔高度的关系进行了研究，发现随着海拔高度的逐渐增大，中老年男性红细胞压积参考值也在逐渐增大，相关性很显著．用一元回归分析的方法推导出了一个回归方程．如果知道了中国某地的海拔高度，就可以用回归方程估算这个地区的中老年男性红细胞压积参考值．     

对氨基苯甲酸酯类紫外吸收性能的定量构效关系——Ⅱ.化合物紫外吸收光谱的构效关系

对十个化合物的紫外吸收性能进行了测定。对其紫外吸收构效关系进行了探索,用振子强度f_n的概念来反映化合物的紫外吸收强度。结果表明f_n与PPP量子化学参数SOSC修之间存在着定量关系。在考虑到溶剂和不同取代基的影响后,发现紫外吸收频率和PPP量子化学参数——前线轨道能量差△E_(?),之间也有良好的线性关系。     

影响氟哌酸抗菌活性及临床疗效的因素

本文从理化性质、原料、生产工艺、剂型、联合用药等方面对影响氟哌酸及其制剂的抗菌活性和临床疗效的因素进行了分析,为临床合理用药提供了理论依据.     

论党的十五大以来中国经济体制改革的新发展

随着改革的深入，中国经济体制改革进入了新的发展时期。党的十五大以来，中国的经济体制改革在所有制结构的优化、国有企业的改革、分配结构和分配方式的完善上取得了新的发展，推动了中国经济的进步。     

Synthesis of macrocyclic natural products by catalyst-controlled stereoselective ring-closing metathesis

Many natural products contain a C = C double bond through which various other derivatives can be prepared; the stereochemical identity of the alkene can be critical to the biological activities of such molecules. Catalytic ring-closing metathesis (RCM) is a widely used method for the synthesis of large unsaturated rings; however, cyclizations often proceed without control of alkene stereochemistry. This shortcoming is particularly costly when the cyclization reaction is performed after a long sequence of other chemical transformations. Here we outline a reliable, practical and general approach for the efficient and highly stereoselective synthesis of macrocyclic alkenes by catalytic RCM; transformations deliver up to 97% of the Z isomer owing to control induced by a tungsten-based alkylidene. Utility is demonstrated through the stereoselective preparation of epothilone C (refs 3-5) and nakadomarin A (ref. 6), the previously reported syntheses of which have been marred by late-stage, non-selective RCM. The tungsten alkylidene can be manipulated in air, delivering the products in useful yields with high stereoselectivity. As a result of efficient RCM and re-incorporation of side products into the catalytic cycle with minimal alkene isomerization, desired cyclizations proceed in preference to alternative pathways, even under relatively high substrate concentration.     

基于数据整合视角的高校教职工慢病健康管理的应用

目的:通过以高校大数据平台为基础的健康数据整合,提出了基于大数据平台的高校慢病管理建议.方法:以某高校2016—2019年4年的教职工健康体检数据为基础,通过性别、职称、职务、学历的分层,进而对常见慢性病如超重、高血压、高血糖、高血脂的发生状况进行对照和原因分析.结果:超重、高血压、高血糖、高血脂的人数男性高于女性,而女性的年平均增长率却不同程度高于男性;在职称、职务、学历分层统计中,呈现出明显年轻化趋势.结论:以学校"幸福工程"为代表的健康促进项目对于教职工健康状况的改善和提升均有较大的促进作用,应建立长效机制.基于大数据平台的校园慢病管理,应在提高认识、完善机制、协同融入、互联互通方面加大力度,有效提升应用成果.     

Nurtured to follow the crowd: A twin study on conformity

Why are some of us easily affected by the majority’s action whereas others frequently make unique choices? In this behavioral genetic study on conformity,we designed a social episode to investigate the genetic and environmental origin of individual differences in conforming behavior during psychosocial development.Specifically,107 monozygotic(MZ) and 74 dizygotic(DZ) twin pairs(age 7-19) were asked to choose a pen from a group of pens either with the majority color or with the minority color.We found that the resemblance between MZ twins in selecting the pen with the majority color was not significantly higher than that between DZ twins,suggesting that individual differences in conformity are due almost exclusively to the environment.Moreover,biometric model fitting revealed that the shared environmental component played a sizable role in shaping individuals’ conforming behavior,and the influence increased with age(from 16% to 26%).Taken together,our study suggests that the common family and cultural environment has important ramifications for conformity.