Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

基于动态语义服务描述的服务匹配的研究

本文将动态描述逻辑与语义服务描述语言相结合,提出了一种动态语义描述方法来描述Web服务,并在经典服务匹配基础上进行改进,完善了服务匹配的类型,提高了Web服务的查全率与查准率。     

An Empirical Study of Effects of Chinese Government＇s Tax Revenue and Expenditure on Its GDP＇s Growth

Public spending is a major policy tool for the government to adjust the macro economic progress. This paper characterizes the effects of shocks in government spending and taxes on Chinese economy growth since 1978. It does so by using a mixed structural VAR （SVAR） approach. Identification is achieved by using institutional information about the tax and spending to identify automatic and discretionary response, and by implication, to infer fiscal shocks. The results show positive government spending shocks as having a positive effect on output, and positive tax shocks as having a negative effects.     

On-Line Scheduling with Rejection on Identical Parallel Machines

In this paper, we consider the on-line scheduling of unit time jobs with rejection on rn identical parallel machines. The objective is to minimize the total completion time of the accepted jobs plus the total penalty of the rejected jobs. We give an on-line algorithm for the problem with competitive ratio 1/2 （2 ＋√3） ≈ 1.86602.     

非线性溃变理论物质结构的系统制约观

基于物质结构实在性和非线性演化模型而提出的溃变理论是非线性理论的观念性观点。本文从四个方面概括了非线性溃变理论的物质系统不同于西方第一推动体系的制约观。（１）在整体观中具体完善了事物演化的“稳定,渐变,不稳定,突变,通过不连续溃变并演化为新的稳定,渐变……”的系统整体演化链。（２）以物质结构的非均匀性提出了第二搅动下物质的涡旋结构观,揭示了“天人合一”的物质性。（３）在结构信息控制观中阐述了非均匀     

黑大蒜多糖对X射线辐射损伤小鼠的防护作用

目的 探讨黑大蒜多糖对X射线辐射损伤小鼠的防护作用.方法 将75只雄性昆明小鼠按体质量随机分为空白对照组、辐射模型组、黑大蒜多糖低、中、高剂量组(给药剂量分别为150、300、600 mg/kg).小鼠于辐射前进行预防性给药,黑大蒜多糖各剂量组每日分别灌胃2 mL不同浓度黑蒜多糖提取物,空白对照和辐射模型组灌胃2 mL...     

Angular glint calculation and analysis of radar targets via adaptive cross approximation algorithm

Angular glint is a significant electromagnetic （EM） scattering signature of extended radar targets. Based on the adaptive cross approximation （ACA） algorithm accelerated method of moments （MoM） and the plane incident wave assumption, the narrowband, wideband and newly developed high-resolution range profile （HRRP） based angular glint calculation formulations are derived and applied to arbitrarily shaped three-dimensional （3D） perfectly electrical y conducting （PEC） objects. In addition, the near-field angular glint is emphasized, which is of great importance for radarseeker applications. Furthermore, with the HRRP based angular glint, an approach to rigorously determine range resolution cel s which own relatively smal er angular glint is provided. Numerical results are presented with new findings to demonstrate the usefulness of the developed formulations.     

浅谈称重传感器工作原理及故障排除

称重传感器是电子计价秤的重要部件,它精度高、灵敏度高、稳定性强,具有抗偏载等多种性能,操作方便快捷可靠.它的作用是把加到秤盘上的物体重量转换成与该重量成比例的电信号.其工作原理是将输出的电信号经放大器放大,并经A/D 转换后由相关电路显示出称重信息.本文就称重传感器的应用进行了探讨.     

高等数学课程设置的多样化研究

由于专业和学生之间存在差异,在高等数学课程设置上必须实行多样化。具体说来,把高等数学的学习内容分为三个模块:基础模块、拓展模块(基地班)和应用模块,实践表明,这种多样化的高等数学课程设置取得了较好的教学效果。     

具有较小最大度的临界图边数的下界

运用Discharge法给出了不含2点和3点的6临界图及不含4点和5点的7临界图边数的下界．