Seasonal changes in the uptake capacity of the suprachiasmatic nucleus for3H-serotonin

Summary The suprachiasmatic nucleus, a hypothalamic center important in mediation of circadian and estrous cycles, is shown in adult rats to have seasonal changes in its uptake capacity in vitro for³H-serotonin.Supported in part by grants from the National Institute of Mental Health (MH-25091), the National Institute of Health (HD-10263, HD-03352, 5-T01-HD00104-10), USPHS, and the Ford Foundation (grant No. 630-0505 B, C).     

Fras1 deficiency results in cryptophthalmos,renal agenesis and blebbed phenotype in mice

Loss of tight association between epidermis and dermis underlies several blistering disorders and is frequently caused by impaired function of extracellular matrix (ECM) proteins. Here we describe a new protein in mouse, Fras1, that is specifically detected in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos. Loss of Fras1 function results in the formation of subepidermal hemorrhagic blisters as well as unilateral or bilateral renal agenesis during mouse embryogenesis. Postnatally, homozygous Fras1 mutants have fusion of the eyelids and digits and unilateral renal agenesis or dysplasia. The defects observed in Fras1-/- mice phenocopy those of the existing bl (blebbed) mouse mutants, which have been considered a model for the human genetic disorder Fraser syndrome. We show that bl/bl homozygous embryos are devoid of Fras1 protein, consistent with the finding that Fras1 is mutated in these mice. In sum, our data suggest that perturbations in the composition of the extracellular space underlying epithelia could account for the onset of the blebbed phenotype in mouse and Fraser syndrome manifestation in human.     

违纪大学生的自尊水平及与家庭因素的关系

文章通过数据统计发现，违纪大学生的自尊水平与其他大学生在总体自尊，外貌，体能等方面有明显的差异，这种差异与家庭的经济状况，父母文化程度，是否独生子女显著相关。     

论体育教师的威信

以体育教师的威信作为研究的出发点，着重讨论了有威信的教师应具备的能力，教师威信对教学效果的影响及形成威信有关的几个因素，要注意的事项，强调作为体育教师，树立威信是十分必要的。     

L'isolement de l'α-amylase de pancréas

Summary The -amylase of hog pancreas has been purified and the degree of purity controled by electrophoresis. The active substance is a protein which can dissociate in an unstable high molecular component and a thermostable component of low molecular weight.     

DL-MPWFRFT与星座扰乱的卫星隐蔽通信系统

针对4-WFRFT隐蔽通信系统,非目的接收机在一定时间内仍能有效的通过参数扫描获得解调参数的不足,提出了一种采用双层多项多参数加权分数阶傅里叶变换(DL-MPWFEFT)与星座扰乱的卫星隐蔽通信系统。在多参数WFRFT的基础上提出了DL-MPWFRFT,通过星座图的研究,分析了DL-MPWFRFT信号的隐蔽原理与特性,为进一步增加信号的隐蔽性,信号在DL-MPWFRFT变换后又增加了星座扰乱相位。最后,从误码率的对比,参数扫描次数两方面分别定性定量的说明了所提系统的抗截获性优势。通过对系统误码率进行对比仿真分析,发现即使信噪比达到15dB时,非目的接收机解调误码率仍在0.4以上。非目的接收机通过参数扫描获得正确解调参数,需进行(M/0.000 5)2次扫描。     

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Multiple studies have confirmed the contribution of rare de novo copy number variations to the risk for autism spectrum disorders. But whereas de novo single nucleotide variants have been identified in affected individuals, their contribution to risk has yet to be clarified. Specifically, the frequency and distribution of these mutations have not been well characterized in matched unaffected controls, and such data are vital to the interpretation of de novo coding mutations observed in probands. Here we show, using whole-exome sequencing of 928 individuals, including 200 phenotypically discordant sibling pairs, that highly disruptive (nonsense and splice-site) de novo mutations in brain-expressed genes are associated with autism spectrum disorders and carry large effects. On the basis of mutation rates in unaffected individuals, we demonstrate that multiple independent de novo single nucleotide variants in the same gene among unrelated probands reliably identifies risk alleles, providing a clear path forward for gene discovery. Among a total of 279 identified de novo coding mutations, there is a single instance in probands, and none in siblings, in which two independent nonsense variants disrupt the same gene, SCN2A (sodium channel, voltage-gated, type II, α subunit), a result that is highly unlikely by chance.     

一种由1，4—二酰基氨基硫脲合成1，4—二酰基氨基脲的新方法

介绍一种由1，4-二酰基氨基硫脲合成1，4-二酰基氨基脲方便有效的新方法，1-芳氧乙酰基-4-对甲苯氧乙酰基氨基硫脲在水溶液中与碘酸钾作用高产率制得一系列新化合物-1-芳氧乙酰基-4-对甲苯氧乙酰基氨基脲。     

猪血丙种球蛋白的制备工艺研究

报道了运用低温乙醇与明矾吸附、碳吸附相结合，制备猪血丙种球蛋白的工艺，纯度可达９５％以上，回收率达５７％，其他各项指标均达卫生部制定的《中国生物制品规程》标准。