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881.
Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease 总被引:21,自引:0,他引:21
H Kikuta Y Taguchi K Tomizawa K Kojima N Kawamura A Ishizaka Y Sakiyama S Matsumoto S Imai T Kinoshita 《Nature》1988,333(6172):455-457
Epstein-Barr virus (EBV), a ubiquitous human herpesvirus and an aetiological agent of infectious mononucleosis, has a unique tropism for B lymphocytes. Clinical and laboratory features of chronic active EBV infections are chronic or persistent infectious mononucleosis-like symptoms and high antibody titre against early antigens (EA). Kawasaki disease (KD), aetiology unknown, is thought to be self-limited immunologically mediated vasculitis. Clinical features of KD are fever, rash, mucositis, lymphadenopathy and coronary artery damage. We report here a child with chronic active EBV infection accompanied by dilatation of coronary arteries. All the EBV-determined nuclear antigen (EBNA)-positive lymphocytes had exclusively CD4 antigen, as revealed by dual staining immunofluorescence analysis. Southern blot hybridization showed that the purified CD4+ cells harboured EBV genome. 相似文献
882.
D. Galdean D. Petrasincu P. Alangiu S. Ibric N. Voiculetz 《Cellular and molecular life sciences : CMLS》1986,42(5):572-574
Summary The protective effect of Thiola against the genotoxicity, induced by benzo(a)pyrene, in vitro and in vivo, was investigated. By association of Thiola to benzo(a)pyrene a significant decrease of the numerical and structural chromosome aberrations and a reduction of the incidence of c-mitoses has been obtained in human diploid cells, i.e. human embryonic lung fibroblasts of the cell-line ICP-23, and C56Bl/6 mouse bone marrow cells. 相似文献
883.
M. E. Hoffmann D. B. Ciampi N. Duran 《Cellular and molecular life sciences : CMLS》1987,43(2):217-220
Summary A radical anion of 2,3,5,6-tetrahydroxy-2,5-cyclohexadiene-1,4-dione was detected using the EPR technique by complexing with Zn ions. Hydrogen peroxide, superoxide radical anion and hydroxyl radical were also detected in the reaction mixture. Kinetic study and product distribution indicated a probable mixed type one- and two-electron transfer mechanism. A possible relationship between the autooxidation process and the biological activity of substituted quinones was suggested. 相似文献
884.
Regulation of transcription. Flexible interpretation 总被引:1,自引:0,他引:1
885.
Anita Pakrashi P. L. Pakrasi S. N. Kabir 《Cellular and molecular life sciences : CMLS》1979,35(6):843-844
Summary Oral administration of p-coumaric acid to estrogen-primed immature female mice exerts neither estrogenic nor anti-estrogenic activity, but when it is administered to cyclic female mice in single dose at proestrus or in repeated doses, induces alteration in estrus cycle, ovarian and uterine weight and structure.The authors wish to thank Dr S. C. Pakrashi and his associates of Medicinal Chemistry Department for isolating the compound. Thanks are also due for granting Senior Research Fellowship to P.P. and Junior Research Fellowship to S.N.K. respectively. 相似文献
886.
S. Pearson P. B. Nunn N. Joan Abbott 《Cellular and molecular life sciences : CMLS》1979,35(10):1363-1364
Summary The action potential in amphibian sciatic nerve in vitro has been reported to be abolished by the topical application ofLathyrus sativus seed extract. We have confirmed this effect, but find that it is probably caused by the high K+ content of such seed extracts and that organic neurotoxins are not implicated.Acknowledgments. We thank the Wellcome Trust for financial support, Professor M.W. Bradbury for help with the ion determinations and Miss M.B. Burbridge of the Tropical Products Institute, London, for obtaining seed from Bombay, India. 相似文献
887.
J Comsa B Baumann M Zeppezauer H Leonhardt N Weber 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(1):185-187
A partially purified thymic extract has determined the development of leucosis in 10 thymectomized irradiated CC57Bl mice out of 25. The pure hormone isolated from the same extract prevented the development of leucosis in intact irradiated Mice. This seems to indicate the presence of a second active substance in the extract (enhancing the development of the leucosis). 相似文献
888.
T Erb G Karolyi A Pampalone A N Eberle J B Baumann E Bürgisser J Girard 《Experientia》1988,44(2):155-157
An immunoradiometric assay for human growth hormone (HGH) has been developed which has a detection limit of 1 ng/l and can measure HGH in unextracted urine from normal children and adults. The assay is based on a two-step procedure, using a solid-phase goat-anti-HGH immunosorbent for immunoextraction and [125I]-labeled monoclonal HGH-antibody for detection and quantification. The assay is not affected by urea, NaCl or changes of pH from 5-8. The mean urine HGH concentration in normal children is 6.78 +/- 7.6 (SD) pg/ml, in patients with HGH-deficiency 1.3 +/- 0.9 pg/ml which increases to 11.7 +/- 13.4 pg/ml on the day of growth hormone injection. 相似文献
889.
T. Okabe K. Hirashima T. Terasima B. Shimizu N. Ohsawa F. Takaku 《Cellular and molecular life sciences : CMLS》1984,40(9):982-984
Summary A human colony-stimulating factor (CSF)-producing tumor transplanted into athymic nude mice released retroviruses in vitro. The viruses induced CSF activity in human fibroblastic cell lines. 相似文献
890.
M. Nishikimi N. Yamauchi K. Kiuchi K. Yagl 《Cellular and molecular life sciences : CMLS》1981,37(5):479-480
Summary Immunological cross-reactivity of L-gulonolactone oxidase of different species (rat, chicken, and bullfrog) was tested by the Ouchterlony technique. Antiserum directed against the enzyme from chicken kidney reacted with rat liver enzyme as well as with bullfrog kidney enzyme. This finding suggests that there is, at least partly, sequence homology among the enzymes from species belonging to the three classes, Mammalia, Aves, and Amphibia. 相似文献