An index of goodness-of-fit based on noncentrality

Akaike's Information Criterion is systematically dependent on sample size, and therefore cannot be used in practice as a basis for model selection. An alternative measure of goodness-of-fit, based like Akaike's on the noncentrality parameter, appears to be consistent over variations in sample size.     

摩擦非线性环节的特性、建模与控制补偿综述

首先介绍了机械伺服系统中摩擦非线性环节的动态、静态特性的研究成果和目前常用的几种摩擦模型 ,讨论了摩擦非线性环节对伺服系统的动态性能和静态性能的影响 ,以及摩擦非线性环节导致的极限环振荡、低速爬行等现象。然后对有关摩擦补偿方法方面的研究成果进行了总结 ,介绍了传统的摩擦补偿方法和基于智能控制理论的摩擦补偿方法方面的研究成果。最后 ,展望了该领域今后的发展方向。     

多参考预测链的时域可扩展性和抗错性

网络的带宽抖动和数据传输错误是影响视频传输的重要原因。该文提出了一种新的多参考帧图像预测的视频编码算法,即多参考预测链,使视频具有时域可扩展性和抗错性解决网络的这两个潜在问题。该算法中P帧之间的参考预测关系构成多条链状结构,使视频具有时域可扩展性。链间的不相关性使每个链可独立解码,从而增强了码流抗错性。该算法采用R-D框架动态的管理预测关系链,从而适合网络带宽的变化而获得最佳的终端视觉效果。仿真实验表明,采用多参考预测链编码的码流时域可扩展性的应用非常可行,且表现出较高的抗错性。     

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consuming pathways, and protects the heart against ischaemic injury and apoptosis. A role for circulating hormones such as adiponectin and leptin in the activation of AMPK has received recent attention. Whether local autocrine and paracrine factors within target organs such as the heart modulate AMPK is unknown. Here we show that macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury. Germline deletion of the Mif gene impairs ischaemic AMPK signalling in the mouse heart. Human fibroblasts with a low-activity MIF promoter polymorphism have diminished MIF release and AMPK activation during hypoxia. Thus, MIF modulates the activation of the cardioprotective AMPK pathway during ischaemia, functionally linking inflammation and metabolism in the heart. We anticipate that genetic variation in MIF expression may impact on the response of the human heart to ischaemia by the AMPK pathway, and that diagnostic MIF genotyping might predict risk in patients with coronary artery disease.     

Bit-Depth Scalable Coding Using a Perfect Picture and Adaptive Neighboring Filter

Bit-depth scalability is a new research field in the on-going scalable extension of the H.264/AVC (SVC) video coding standard. The key point is to accurately predict the enhancement layer, whose bit depth is 10 or more, from the 8 bit base layer. An improved inter-layer prediction scheme for bit-depth scalability was developed that ensures compatibility with the standard and improves the encoding efficiency. The scheme uses a “perfect” 8 bit picture with an adaptive neighbor filter whose coefficients are optimized by minimizing the block distortion between the 8 bit reconstructed picture and the “perfect” picture to achieve a more precise 10 bit prediction based on the filtered picture. Double arithmetic precision is used to further improve the encoding efficiency. Experimental results show that the scheme outperforms the recent joint video team (JVT) proposal in the joint scalable video model (JSVM).     

A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis

Cellular and Molecular Life Sciences - Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is an incurable childhood brain disease. The thirteen forms of NCL are caused by mutations...     

基于神经网络的直流电动机实时跟踪控制

研究了三层对角回归神经网络(DRNN)用于直流电动机实时控制的方法.首先采用动态反传算法训练神经网络以辨识直流电动机的逆模型,然后将这一训练后的网络作为前馈控制器与常规反馈控制器一起输出控制电压,以控制系统跟踪位置或速度指令.该算法简单、计算量小,适于实时控制.仿真结果表明了该方法的有效性.     

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.