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McPherson JD Marra M Hillier L Waterston RH Chinwalla A Wallis J Sekhon M Wylie K Mardis ER Wilson RK Fulton R Kucaba TA Wagner-McPherson C Barbazuk WB Gregory SG Humphray SJ French L Evans RS Bethel G Whittaker A Holden JL McCann OT Dunham A Soderlund C Scott CE Bentley DR Schuler G Chen HC Jang W Green ED Idol JR Maduro VV Montgomery KT Lee E Miller A Emerling S Kucherlapati Gibbs R Scherer S Gorrell JH Sodergren E Clerc-Blankenburg K Tabor P Naylor S Garcia D de Jong PJ Catanese JJ Nowak N 《Nature》2001,409(6822):934-941
The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map. 相似文献
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