The effect of cannabinol delta1-tetrahydro-cannabinol clearance from the blood.

The co-administration of cannabinol with delta1-tetrahydrocannabinol accelerates the rate of clearance of delta1-tetrahydrocannabinol from rat blood. This increased rate of clearance appears to follow that of cannabinol. The implications of these findings are discussed.     

Cannabidiol and its pharmacokinetic interaction with delta1-tetrahydrocannabinol.

Co-administration of cannabidiol with delta1-tetrahydrocannabinol was found to have no effect on the rate of disappearance of delta1-tetrahydrocannabinol from the blood of rats. The implications of this finding are discussed.     

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles, but it is unknown how CRIg selectively recognizes proteolytic C3-fragments and whether binding of CRIg to C3b inhibits convertase activation. Here we present the crystal structure of C3b in complex with CRIg and, using CRIg mutants, provide evidence that CRIg acts as an inhibitor of the alternative pathway of complement. The structure shows that activation of C3 induces major structural rearrangements, including a dramatic movement (>80 A) of the thioester-bond-containing domain through which C3b attaches to pathogen surfaces. We show that CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases. The structure provides insights into the complex macromolecular structural rearrangements that occur during complement activation and inhibition. Moreover, our structure-function studies relating the structural basis of complement activation and the means by which CRIg inhibits the convertases provide important clues to the development of therapeutics that target complement.     

TS-1分子筛合成与苯羟基化反应性能考察

以TEOS、TBOT和自制的w =20 % TPAOH 水溶液为原料,合成了TS- 1 分子筛,并经IR、XRD和Raman 光谱等手段证实。用该分子筛作催化剂对芳烃羟基化催化性能进行考察,并在实验的基础上推测了TS- 1 分子筛催化芳烃直接羟基化的反应历程。     

高原鼢鼠油脂中亚油酸含量定量分析

用气象色谱方法对高原鼢鼠油脂中亚油酸含量进行了定量分析,并对方法的准确度进行了检验。结果发现:高原鼢鼠油脂中亚油酸含量为10.84%±0.38%,皂化和酯化最佳时间分别为15min和7min,亚油酸甲酯标准曲线回归系数r=0.9999,亚油酸甲酯色谱峰面积的相对偏差为0.0124,样品亚油酸甲酯回收率为95.08%。     

煤岩破坏电磁辐射记忆效应特性及产生机制

通过实验研究了不同加载方式下的煤岩破坏电磁辐射记忆效应特性;借助细观损伤力学和电磁动力学等理论,对煤岩内部结构损伤扩展及电磁辐射产生机制进行了分析。结果表明,煤岩破坏电磁辐射具有记忆效应特性,但记忆最大历史应力、纵向应变的能力明显优于记忆横向应变和体应变的能力,受载煤岩损伤破坏过程的不可逆性是煤岩破坏电磁辐射产生记忆效应的直接原因。     

基于角色和任务的工作流访问控制管理模型

针对现有访问控制模型在工作流系统安全方面存在的不足,提出一种基于角色和任务的工作流访问控制管理模型(ATRBAC).该模型将ARBAC模型中的管理思想融入TRBAC模型,并引入管理员及管理权限,同时对管理员实行层次管理,解决了系统管理员的权限过大而产生的隐患,加强了系统的安全性.     

基于TrustZone的嵌入式系统安全性研究

嵌入式系统安全性的研究逐渐成为网络安全领域的一个重要课题。对基于TrustZone技术的嵌入式系统的安全性进行了研究,介绍了嵌入式安全操作系统、可信计算、CPU特权体系结构以及TrustZone技术。研究表明,基于可信硬件和安全操作系统的嵌入式系统安全体系,是解决嵌入式系统安全问题的可行方案。胡：2011一06—08