Subwavelength-diameter silica wires for low-loss optical wave guiding

Silica waveguides with diameters larger than the wavelength of transmitted light are widely used in optical communications, sensors and other applications. Minimizing the width of the waveguides is desirable for photonic device applications, but the fabrication of low-loss optical waveguides with subwavelength diameters remains challenging because of strict requirements on surface roughness and diameter uniformity. Here we report the fabrication of subwavelength-diameter silica 'wires' for use as low-loss optical waveguides within the visible to near-infrared spectral range. We use a two-step drawing process to fabricate long free-standing silica wires with diameters down to 50 nm that show surface smoothness at the atomic level together with uniformity of diameter. Light can be launched into these wires by optical evanescent coupling. The wires allow single-mode operation, and have an optical loss of less than 0.1 dB mm(-1). We believe that these wires provide promising building blocks for future microphotonic devices with subwavelength-width structures.     

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

During the evolution of cancer, the incipient tumour experiences 'oncogenic stress', which evokes a counter-response to eliminate such hazardous cells. However, the nature of this stress remains elusive, as does the inducible anti-cancer barrier that elicits growth arrest or cell death. Here we show that in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung and colon, the early precursor lesions (but not normal tissues) commonly express markers of an activated DNA damage response. These include phosphorylated kinases ATM and Chk2, and phosphorylated histone H2AX and p53. Similar checkpoint responses were induced in cultured cells upon expression of different oncogenes that deregulate DNA replication. Together with genetic analyses, including a genome-wide assessment of allelic imbalances, our data indicate that early in tumorigenesis (before genomic instability and malignant conversion), human cells activate an ATR/ATM-regulated DNA damage response network that delays or prevents cancer. Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression.     

Potential for controlling the spread of Centaurea maculosa with grass competition

Spotted knapweed ( Centaurea maculosa Lam.) is a major rangeland and roadside weed of the northern Rocky Mountains. It is often found in plant communities dominated by Pseudoroegneria spicatum or Festuca idahoensis , but it rarely invades roadsides dominated by Bromus tnermis Leyss. Aboveground biomass of the 3 grass species grown in mixture with Centaurea was compared to growth in monoculture at a range of nitrogen input levels. The results suggest that Bromus is capable of suppressing the growth of Centaurea with the degree of suppression increasing with increasing nitrogen levels. The 2 native grasses had no impact on Centaurea under the controlled environment conditions of this study.     

Body size, body composition, and behavior of juvenile Belding ground squirrels

Juvenile Belding ground squirrels were studied in the Sierra Nevada. Females were more trappable, had smaller home ranges, and tended to enter hibernation earlier than males. The primary sex ratio was 1:1. Individuals first emerged from the natal burrow at three to four weeks of age and a body weight of 35 g. Body weight and linear dimensions increased thereafter until hibernation began. Maximum prehibernatory weight of 200 to 260 g was attained at about 12 weeks of age. Prehibernatory fattening began at about six weeks of age. Maximum lipid stores attained weighed about 80 percent of the lean, dry body compartment. Seasonal changes occurred in weight of white and brown fat depots, adrenal glands, spleen, heart, kidneys, liver, and testes. Annual variations in snowpack and emergence schedule caused the reproductive period, and thus phenology of juveniles, to vary by as much as three weeks. The last animals to immerge were unusually small, being from late litters. Nonetheless, they may have had lipid stores sufficient for surviving hibernation.     

Spotted knapweed distribution in stock camps and trails of the Selway-Bitterroot Wilderness

This article documents spotted knapweed ( Centaurea maculosa Lam.) in 30 campsites and along 5 trails in the Selway-Bitterroot Wilderness and assesses the role of disturbance and environmental factors in controlling infestation. Spotted knapweed was present in only 6 of 30 surveyed campsites and limited portions of all 5 trails that were sampled. All spotted knapweed in camps was below 1700 m elevation, in open canopy, and in areas with an opportunity class disturbance ranking of 3 or 4. Overall disturbance levels measured using U.S. Forest Service Site Impact Worksheets (SIWs) did not help predict occurrence of spotted knapweed, although bare mineral soil, vegetation loss, and development variables of SIWs provide some explanation of spotted knapweed presence or absence. There was no significant difference in knapweed frequency between areas used predominantly by horses and those use by humans within camps. Over 95% of spotted knapweed along trails was found within 0.5 km of the trailhead, occurred within 4.6 m of the trail, and had low reproductive potential. If the Bitterroot portion of the Selway-Bitterroot Wilderness is representative of forested wilderness areas in the Northern Rockies, then the perceived threat of spotted knapweed to wilderness areas may subsequently exceed the actual danger in many instances. Study findings indicated that managers should conduct surveys before initiating costly control measures in wilderness areas, that eradication may be a viable alternative when spotted knapweed numbers are this low, and that regulations promoting minimum-impact camping should reduce spotted knapweed infestation.