排序方式: 共有30条查询结果,搜索用时 31 毫秒
21.
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function 总被引:64,自引:0,他引:64
Parrish-Novak J Dillon SR Nelson A Hammond A Sprecher C Gross JA Johnston J Madden K Xu W West J Schrader S Burkhead S Heipel M Brandt C Kuijper JL Kramer J Conklin D Presnell SR Berry J Shiota F Bort S Hambly K Mudri S Clegg C Moore M Grant FJ Lofton-Day C Gilbert T Rayond F Ching A Yao L Smith D Webster P Whitmore T Maurer M Kaushansky K Holly RD Foster D 《Nature》2000,408(6808):57-63
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction. The full-length receptor was expressed in BaF3 cells, which created a functional assay for ligand detection and cloning. Conditioned media from activated human CD3+ T cells supported proliferation of the assay cell line. We constructed a complementary DNA expression library from activated human CD3+ T cells, and identified a cytokine with a four-helix-bundle structure using functional cloning. This cytokine is most closely related to IL2 and IL15, and has been designated IL21 with the receptor designated IL21 R. In vitro assays suggest that IL21 has a role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow, in the proliferation of mature B-cell populations co-stimulated with anti-CD40, and in the proliferation of T cells co-stimulated with anti-CD3. 相似文献
22.
23.
An opioid benzodiazepine 总被引:5,自引:0,他引:5
D R?mer H H Büscher R C Hill R Maurer T J Petcher H Zeugner W Benson E Finner W Milkowski P W Thies 《Nature》1982,298(5876):759-760
24.
L. R. Cruthers R. D. Haugwitz B. V. Maurer 《Cellular and molecular life sciences : CMLS》1980,36(12):1389-1390
Summary A series of phenylguanidine anthelminties has been discovered to be active by injection against nematode and trematode species.For the previous paper in this series, see R. D. Haugwitz, B. V. Maurer, G. A. Jacobs, V. L. Narayanan, L. R. Cruthers and J. Szanto, J. med. Chem.22, 1113 (1979). 相似文献
25.
Briggs TA Rice GI Daly S Urquhart J Gornall H Bader-Meunier B Baskar K Baskar S Baudouin V Beresford MW Black GC Dearman RJ de Zegher F Foster ES Francès C Hayman AR Hilton E Job-Deslandre C Kulkarni ML Le Merrer M Linglart A Lovell SC Maurer K Musset L Navarro V Picard C Puel A Rieux-Laucat F Roifman CM Scholl-Bürgi S Smith N Szynkiewicz M Wiedeman A Wouters C Zeef LA Casanova JL Elkon KB Janckila A Lebon P Crow YJ 《Nature genetics》2011,43(2):127-131
We studied ten individuals from eight families showing features consistent with the immuno-osseous dysplasia spondyloenchondrodysplasia. Of particular note was the diverse spectrum of autoimmune phenotypes observed in these individuals (cases), including systemic lupus erythematosus, Sj?gren's syndrome, hemolytic anemia, thrombocytopenia, hypothyroidism, inflammatory myositis, Raynaud's disease and vitiligo. Haplotype data indicated the disease gene to be on chromosome 19p13, and linkage analysis yielded a combined multipoint log(10) odds (LOD) score of 3.6. Sequencing of ACP5, encoding tartrate-resistant acid phosphatase, identified biallelic mutations in each of the cases studied, and in vivo testing confirmed a loss of expressed protein. All eight cases assayed showed elevated serum interferon alpha activity, and gene expression profiling in whole blood defined a type I interferon signature. Our findings reveal a previously unrecognized link between tartrate-resistant acid phosphatase activity and interferon metabolism and highlight the importance of type I interferon in the genesis of autoimmunity. 相似文献
26.
Summary Labelling of neutrophil granulocytes in the blood and sputum of rats was followed by autoradiography for 120 h after starting a continuous infusion of3H-thymidine). 相似文献
27.
28.
29.
R A Maurer 《Nature》1981,294(5836):94-97
30.
The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein 总被引:9,自引:0,他引:9
Pusch CM Zeitz C Brandau O Pesch K Achatz H Feil S Scharfe C Maurer J Jacobi FK Pinckers A Andreasson S Hardcastle A Wissinger B Berger W Meindl A 《Nature genetics》2000,26(3):324-327
X-linked congenital stationary night blindness (XLCSNB) is characterized by impaired scotopic vision with associated ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity. Genetic mapping in families with XLCSNB revealed two different loci on the proximal short arm of the X chromosome. These two genetic subtypes can be distinguished on the basis of electroretinogram (ERG) responses and psychophysical testing as a complete (CSNB1) and an incomplete (CSNB2) form. The CSNB1 locus has been mapped to a 5-cM linkage interval in Xp11.4 (refs 2,5-7). Here we construct and analyse a contig between the markers DXS993 and DXS228, leading to the identification of a new gene mutated in CSNB1 patients. It is partially deleted in 3 families and mutation analysis in a further 21 families detected another 13 different mutations. This gene, designated NYX, encodes a protein of 481 amino acids (nyctalopin) and is expressed at low levels in tissues including retina, brain, testis and muscle. The predicted polypeptide is a glycosylphosphatidylinositol (GPI)-anchored extracellular protein with 11 typical and 2 cysteine-rich, leucine-rich repeats (LRRs). This motif is important for protein-protein interactions and members of the LRR superfamily are involved in cell adhesion and axon guidance. Future functional analysis of nyctalopin might therefore give insight into the fine-regulation of cell-cell contacts in the retina. 相似文献