External synchronization of two dynamical systems with uncertain parameters

External synchronization is addressed as two or more dynamical systems with synchronous motions, which is also regarded as master-slave system. In this paper, two dynamical systems, one employs a hysteretic term to model the friction phenomenon, the other involves a hardening stiffness component with the third order of displacement due to flexible deformation, are controlled to converge to the same trajectory. The control strategy is extended from feedback control for all parameters known to adaptive contro...     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.     

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.     

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.     

A New Adaptive Formant Vocoder

A new type of vocoder system based upon formant analysis is presented in this paper. The LMS adaptive algorithm is used for tracking formants of speech signals. The results of computer simulation show that the new vocoder has better synthesized speech quality.     

海湾战争的特点和启示

本文阐述海湾战争的特点和启示,着重分析了现代空袭模式和防空面临的问题。     

头盘微小间隙动态浮动理论研究

本文对微小浮动间隙的磁头浮动块的动态浮动性能进行了仿真计算。在考虑头盘碰撞的基础上,分析了磁头浮动块对冲击的响应。分析结果表明:在微小浮动间隙的头盘系统中,盘片表面粗糙度和外界干扰冲击对浮动块的浮动性能影响较大。新的动态浮动理论中,必须包含头盘磁撞的研究。     

关于关系型与面向对象型数据库管理系统的争论

本文介绍了关系型数据库管理系统(RDBMS)与面向对象数据库管理系统(OODBMS)的技术,详细评述了人们围绕这两种技术展开的争论。     

时滞控制系统变结构控制器的一种等效设计方法

本文对时滞控制系统的变结构控制器提出了一种等效的设计方法。此方法因只需对相应的无时滞控制系统进行变结构控制器设计,所以不仅简化了变结构控制器本身的设计,而且也相应的简化了切换面的设计。同时,还给出了这种等效方法的时滞范围及系统数值仿真,仿真结果表明此方法的可行性及其效果的优良性。     

用数字波束形成技术测量干扰环境中目标的方向

本文讨论了在干扰环境中利用数字波束形成技术确定目标方向的方法,给出了计算机模拟结果。测量目标角度是基于单脉冲技术中的和差波束的方法。由于各路接收机幅相误差和算法本身的影响,差波束指向零点将产生漂移且零深不够理想,影响了测角精度。本文提出了在差波束的理想指向零点方向用正交化算法产生一零点的办法来校正零点漂移和加深零深,又不影响差方向图的其它性能,从而为用数字波束形成技术精密测角提出了一条路径。另外,本文给出了为消除主瓣干扰而对和差方向图影响的模拟结果。