Localization of a Robotic Capsule for GI Motility Inspection with a Portable Ultrasonic System

IntroductionResearchesonmicromedicaldeviceandmicromedicalrobot,especiallytheinvivoinspectionsystemworkinginalimentarycanalorinbloodvesselwithlittledamageornondamagetohumanbodyhavebeenundertakenandreportedbyexpertsinmanycountries.Thesesystemsusuallyownmanyadvantagessuchas:smallvolume,lowpowerconsumption,littleinterferencetoworkingsurroundings,socangreatlyenlargethescopesofmedicalexaminationandrelievethepatientsofdiscomfortcausedbynormalprocedures.Thecapsuleendoscope“NORIKAsystem”developedby…     

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.

Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has been the lack of standards for presenting and exchanging such data. Here we present a proposal, the Minimum Information About a Microarray Experiment (MIAME), that describes the minimum information required to ensure that microarray data can be easily interpreted and that results derived from its analysis can be independently verified. The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools. With respect to MIAME, we concentrate on defining the content and structure of the necessary information rather than the technical format for capturing it.     

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment. Cleavage of the C-terminal fragment by gamma-secretase(s) leads to the formation of Abeta. The pathogenic mutation K670M671-->N670L671 at the beta-secretase cleavage site in APP, which was discovered in a Swedish family with familial Alzheimer's disease, leads to increased beta-secretase cleavage of the mutant substrate. Here we describe a membrane-bound enzyme activity that cleaves full-length APP at the beta-secretase cleavage site, and find it to be the predominant beta-cleavage activity in human brain. We have purified this enzyme activity to homogeneity from human brain using a new substrate analogue inhibitor of the enzyme activity, and show that the purified enzyme has all the properties predicted for beta-secretase. Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase.     

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.     

纤维对PEI改性环氧树脂单向复合材料形态的影响

人们改善环氧树脂基复合材料的脆性通常只改善环氧树脂基体和增强纤维间的界面，提高环氧树脂韧性的另一种常用方法是添加初始相容性良好的热塑性树脂如聚醚酰亚胺，在某一转化率（取决于体系的组成和反应温度）时体系发生相转变，体系最终的形态由相转变速率和环氧树脂反应速度所控制。本文作者研究了两种增强纤维（玻璃纤维和碳纤维）对不同环氧树脂／聚醚酰亚爱体系形态形成的影响，结果发现体系中纤维的存在不会影响基体相分离过程，但会改变体系的最终形态；形态的变化与纤维的品种关系不大；基体中不同组分的粘度是影响复合材料形态形成的关键因素。