施工企业防范经营风险初探

施工企业经营风险是指企业在经营中对未来经营环境中的不确定因素与多变性无法全部或精确预测所造成预计支出与收益偏离实际的风险。企业经营风险是在经营过程中产生的,因此,经营风险贯穿于企业生产经营的全过程。     

基于遗传算法的管理信息系统的智能分解

将遗传算法原理应用于管理信息大系统的结构化分解,并对具体分解技术进行了详细描述,最后对一个具体实例进行了仿真计算。仿真说明,该算法具有全局快速收敛性、并行性和极高的分解效率。     

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a key enzyme in plasma triglyceride hydrolysis. Mice carrying the combined lipase deficiency (cld) mutation show severe hypertriglyceridemia owing to a decrease in the activity of LPL and a related enzyme, hepatic lipase (HL), caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (ER). Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1). Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. A human subject homozygous for a deleterious mutation in LMF1 also shows combined lipase deficiency with concomitant hypertriglyceridemia and associated disorders. Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia.     

同时存在导体和电介质的边界时电像法问题研究

讨论了导体与电介质同时存在情况下的电像法问题,指出了文献[1-2]中关于这一问题所出现的一些错误,并给出了正确的解答.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

国际临界带研究发展回顾与美国临界带研究进展介绍

基于对临界带国际发展态势的分析,梳理了临界带的概念;回顾了国际临界带研究的发展历程;并重点对美国在临界带研究方面的进展及其已经部署的6个临界带观测站进行了详细的介绍。     

"大系统"理论及其在温室系统建模中的应用

在简介现代系统工程发展的基础上,引入了“大系统”的基本概念,综述了“大系统”理论的特征,分类和大系统的控制邮将“大系统”理论应用到温室系统建立综合动态仿真模型中的思路,最后对建模方法进行了探讨。     

Game-theoretic approach to power and admission control in hierarchical wireless sensor networks

Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs’ utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm.     

一维双极粘滞量子流体力学模型解的存在性

研究了一类一维稳态双极半导体方程的粘滞量子流体力学模型.该模型包含关于粒子浓度和电流密度的连续方程以及电势Poisson方程的耦合方程组,其中含有三阶量子修正项和二阶粘滞项.该问题在有界区间(0,1)中讨论,并通过边界条件的假设将原方程组变形为常见的形式,得到原问题的等价问题.用截断方法将等价问题正则化,并得到正则化问题解的先验估计.利用Leray-Schauder不动点定理证明正则化问题解的存在性,最后通过L∞估计证明正则化问题的解即为原问题的解,从而证明了原双极粘滞量子流体力学模型存在稳态解.     

Lipids of sulfate-reducing bacteria and sulfur-oxidizing bacteria found in the Dongsheng uranium deposit

U-bearing sandstones from the Dongsheng deposit in Ordos Basin contain abundant C15-C18 fatty acids. The fatty acids may have been derived from modern and ancient organisms including organisms from the intervals of U mineralization. A certain amount of i15:0, a15:0, a17:0 fatty acids coexist with small amounts of i17:1ω7c and 10me16:0, characteristic biomarkers of Desulfovibrio and Desulfobacter sp., respectively. This indicates the existence of sulfate-reducing bacteria (SRB) in the sandstones. The presence of sulfur-oxidizing bacteria (SOB), such as Beggiatoa and Thioploca, is indicated by significant amounts of 16:1ω7c and 18:1ω7c fatty acids. The existence of the SRB in the deposit, as inferred from the fatty acids, is consistent with results from fossilized microorganisms and isotopic compositions of ore-stage pyrite. This suggests that the environment may have been favorable for the SRB to grow since ore formation (9.8-22 Ma). The bacteria may have degraded hydrocarbons directly, or indirectly utilized hydrocarbons degraded by oxic microbes in the deposits. This process may have produced 12C-rich calcite and prominent baseline humps of unresolved complex mixtures (UCM), and 25-demethylated hopanes and tricyclic terpanes. The existence of sulfur-oxidizing bacteria and sulfate-reducing bacteria in the deposit may have resulted in bacterial sulfate reduction to sulfide, re-oxidization of the sulfide to sulfate and subsequent reduction of the sulfate to sulfide. This assertion is supported by ore-stage pyrite with δ34S values as low as-39.2‰, and the lightest sulfate (about 11‰) measured during the Phanerozoic, a difference of more than 46‰.