太阳电池填充因子随日照强度变化的理论分析与计算

根据太阳电池直流模型和最大功率点数学条件,推出短路电流、开路电压、最大功率点电流和电压 以及填充因子随日照强度变化的数学关系式;并选取２个电池分别计算出在不同日照强度下上述电池参数随日 照强度的变化率。验证了短路电流和最大功率点电流是近似跟日照强度成正比,开路电压和最大功率点电压是 近似跟日照强度的自然对数成正比。并提出了填充因子随日照强度的变化关系不具有简单的函数形式,而对不 同的太阳电池其变化关系也迥异。最后用Multisim的模拟结果检验了理论分析计算的正确性。     

基于智能体模拟的结构性疏散计划设计研究

展示了一个基于Agent模拟方法的框架方法,用于为危急中的复杂技术系统设计结构性的疏散计划.该计划利用复杂自适应系统的模拟方式,并采用基于智能体模拟的方法作为认知工具来设计整体系统的疏散方案.结构化的疏散计划应用文中提出的整体性技术框架,没有采用标准化的常规方法.提出了一个使疏散人群能够更加适应的调整危机时刻的紧急情况和减少无效疏散的建议性方案.本框架方法在一个典型的复杂自适应系统一地铁火灾中得到应用.     

三维地学建模技术与Kriging方法在固体矿产储量计算中的应用

结合Kriging方法在计算机上的实现和应用,介绍了运用三维地学建模技术生成矿体的三维品位模型的原理流程以及关键技术,并在此基础上进行矿产资源储最计算.其基本流程为:根据实际地质勘探数据生成矿体三维实体模型;在实体tin模型内部应用块模型方法进行划分,建立矿体块体模型;利用Kriging方法进行插值,生成矿体的品位模型...     

施工企业防范经营风险初探

施工企业经营风险是指企业在经营中对未来经营环境中的不确定因素与多变性无法全部或精确预测所造成预计支出与收益偏离实际的风险。企业经营风险是在经营过程中产生的,因此,经营风险贯穿于企业生产经营的全过程。     

基于遗传算法的管理信息系统的智能分解

将遗传算法原理应用于管理信息大系统的结构化分解,并对具体分解技术进行了详细描述,最后对一个具体实例进行了仿真计算。仿真说明,该算法具有全局快速收敛性、并行性和极高的分解效率。     

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a key enzyme in plasma triglyceride hydrolysis. Mice carrying the combined lipase deficiency (cld) mutation show severe hypertriglyceridemia owing to a decrease in the activity of LPL and a related enzyme, hepatic lipase (HL), caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (ER). Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1). Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. A human subject homozygous for a deleterious mutation in LMF1 also shows combined lipase deficiency with concomitant hypertriglyceridemia and associated disorders. Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia.     

同时存在导体和电介质的边界时电像法问题研究

讨论了导体与电介质同时存在情况下的电像法问题,指出了文献[1-2]中关于这一问题所出现的一些错误,并给出了正确的解答.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

"大系统"理论及其在温室系统建模中的应用

在简介现代系统工程发展的基础上,引入了“大系统”的基本概念,综述了“大系统”理论的特征,分类和大系统的控制邮将“大系统”理论应用到温室系统建立综合动态仿真模型中的思路,最后对建模方法进行了探讨。     

Game-theoretic approach to power and admission control in hierarchical wireless sensor networks

Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs’ utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm.