车用电液比例阀驱动与控制技术的研究

为了满足车辆对比例阀驱动电路可靠、节能及体积小等方面的要求,在分析了比例阀工作原理及传统驱动技术的缺陷的基础上,提出了在车辆上应用PWM驱动技术必要性;并针对该驱动方式开环控制精度低的缺点引入了电流反馈闭环控制技术;最后,通过试验验证了该驱动控制技术的有效性.     

基于遗传算法的管理信息系统的智能分解

将遗传算法原理应用于管理信息大系统的结构化分解,并对具体分解技术进行了详细描述,最后对一个具体实例进行了仿真计算。仿真说明,该算法具有全局快速收敛性、并行性和极高的分解效率。     

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a key enzyme in plasma triglyceride hydrolysis. Mice carrying the combined lipase deficiency (cld) mutation show severe hypertriglyceridemia owing to a decrease in the activity of LPL and a related enzyme, hepatic lipase (HL), caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (ER). Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1). Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. A human subject homozygous for a deleterious mutation in LMF1 also shows combined lipase deficiency with concomitant hypertriglyceridemia and associated disorders. Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia.     

同时存在导体和电介质的边界时电像法问题研究

讨论了导体与电介质同时存在情况下的电像法问题,指出了文献[1-2]中关于这一问题所出现的一些错误,并给出了正确的解答.     

中国濒危红树植物红榄李的种群数量及其分布

红树植物红榄李[Lum n itzera littorea(Jack.)V o igt]在我国现存仅有359株左右,全部分布在海南,极度濒危。具体地点为三亚铁炉港(9株)、陵水大墩村(约340株)、海口的东寨港(10株,移植)。只有陵水的红榄李在一定程度上具有自我繁殖能力。红榄李具有双花期,可与榄李(L.racem osa)混生。红榄李种子萌发率低,人为干扰严重是影响红榄李种群生存的主要原因。建议把陵水大墩村红树林分布区设为保护区,恢复红榄李生境,抢救我国目前唯一一处尚具有自我繁殖潜力的红榄李野生种群。     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

双胆固醇取代Schiff碱衍生物的合成及其自组装性质

设计合成了双胆固醇取代Schiff碱衍生物, 发现该化合物能在苯、 CCl₄、 乙酸丁酯和DMF中自组装形成透明的有机凝胶. 扫描电镜和透射电镜照片表明, 大量一维凝胶纤维的交叉缠绕构成了三维网络结构. UV-vis吸收光谱表明, 在凝胶相中Schiff碱基团之间通过π-π相互作用形成了H-聚集体.     

分层控制算法在过饱和交通干线控制中的应用

提出一种启发式分层控制算法框架来解决过饱和城市交通干线的控制问题.整个控制器由控制层和协调层组成,在控制层,引入主线延误和次线延误的概念,将控制问题描述为一个冲突的多目标控制问题,提出一种新的基于IPNSGA-Ⅱ遗传算法的多目标相容控制策略来产生相邻交叉口的信号配时方案;在协调层,首先确定需要进行协调的交叉口群,然后以主线延误和次线延误为目标,采用IPNSGA-Ⅱ遗传算法进行优化,实现交叉口之间的协调.提出的相容控制策略具有鲁棒性、实时性、动态性的特点,能够实现干线交叉口的实时控制.将该分层算法应用于一个七个交叉口组成的城市交通干线的交通流仿真系统进行测试,仿真结果表明,本文方法比单点控制策略能够更有效的缓解网络中的过饱和状态,减小延误.     

"大系统"理论及其在温室系统建模中的应用

在简介现代系统工程发展的基础上,引入了“大系统”的基本概念,综述了“大系统”理论的特征,分类和大系统的控制邮将“大系统”理论应用到温室系统建立综合动态仿真模型中的思路,最后对建模方法进行了探讨。     

Game-theoretic approach to power and admission control in hierarchical wireless sensor networks

Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs’ utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm.