排序方式: 共有28条查询结果,搜索用时 15 毫秒
21.
Gardner MJ Hall N Fung E White O Berriman M Hyman RW Carlton JM Pain A Nelson KE Bowman S Paulsen IT James K Eisen JA Rutherford K Salzberg SL Craig A Kyes S Chan MS Nene V Shallom SJ Suh B Peterson J Angiuoli S Pertea M Allen J Selengut J Haft D Mather MW Vaidya AB Martin DM Fairlamb AH Fraunholz MJ Roos DS Ralph SA McFadden GI Cummings LM Subramanian GM Mungall C Venter JC Carucci DJ Hoffman SL Newbold C Davis RW Fraser CM Barrell B 《Nature》2002,419(6906):498-511
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria. 相似文献
22.
23.
24.
Kraemer N Issa L Hauck SC Mani S Ninnemann O Kaindl AM 《Cellular and molecular life sciences : CMLS》2011,68(10):1719-1736
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following
the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an
isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to
as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into
basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight
because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in
primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might
lead to disease in humans when the function of this protein is disturbed. 相似文献
25.
26.
27.
H. Arn P. M. Guerin H. R. Buser S. Rauscher E. Mani 《Cellular and molecular life sciences : CMLS》1985,41(11):1482-1484
Summary Pheromone glands and effluvia of the codling moth female containE-8, E-10-dodecadien-1-ol as main component, accompanied by its geometric isomers, the corresponding acetate and aldehyde (both in gland extracts only),E-9-dodecen-1-ol and saturated alcohols of 10 to 18 carbons. Dodecan-1-ol as the most abundant secondary component (about 30% of the female blend) acts in the wind tunnel by widening the dose range over which codling moth males are optimally attracted toE-8, E-10-dodecadien-1-ol.This research was supported by the Swiss National Science Foundation. We thank W. Riggenbach for supplying moths and T. Wildbolz, P. Charmillot and M. Tóth for conducting field trials. 相似文献
28.
H. Arn C. Schwarz H. Limacher E. Mani 《Cellular and molecular life sciences : CMLS》1974,30(10):1142-1144
Zusammenfassung Die Anlockung von Männchen des Apfelwicklers (Laspeyresia pomonella L.) mittrans-8,trans-10-Dodecadien-1-ol (Codlemone) oder mit lebenden Weibchen wird durch verschiedene Analoge des Sexuallockstoffs gehemmt. Starke Inhibitorwirkung zeigtecis-8-Dodecenylacetat. Der graue Knospenwickler,Hedya nubiferana Haw., der ebenfalls durch Codlemone angelockt wird, reagiert spezifisch auf weitere Inhibitoren. 相似文献