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排序方式: 共有109条查询结果,搜索用时 15 毫秒
61.
Striated muscle in the cortex of foetal guinea-pig thymus 总被引:1,自引:0,他引:1
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V. Varga F. V. DeFeudis L. Ossola M. Geffard P. Mandel 《Cellular and molecular life sciences : CMLS》1981,37(6):594-595
Summary Although their body weights were decreased by about 77% and their brain weights by about 30%, high-affinity [3H] muscimol binding to a cerebral membrane fraction was not altered in hereditary pituitary dwarf mice. Marked changes in the level of pituitary growth-associated hormones do not appear to be associated with a change in cerebral GABA-receptors.Supported by a UNESCO/IBRO Fellowship. Permanent address: Semmelweis University Medical School, 1st Institute of Biochemistry, Budapest, Hungary. 相似文献
63.
Insulin stimulates myogenesis in a rat myoblast line 总被引:8,自引:0,他引:8
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The effect of pentobarbital was studied in a mixed population of nerve and glial cells dissociated from brains of 7-day chick embryos and maintained in culture. Pentobarbital-Na was added in various concentrations ranging from 5 X 10(-5) M to 1 X 10(-3) M. The neuronal density was monitored by counting the neurons, neuronal identity was established by staining for Nissl Bodies and acetylcholinesterase. Over a culture period of 3 weeks, it was found that the barbiturate exerts a preferential dose-dependent cytotoxic effect on neurons. 相似文献
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Summary The effect of pentobarbital was studied in a mixed population of nerve and glial cells dissociated from brains of 7-day chick embryos and maintained in culture. Pentobarbital-Na was added in various concentrations ranging from 5×10–5 M to 1×10–3 M. The neuronal density was monitored by counting of neurons, neuronal identity was established by staining for Nissl Bodies and acetylcholinesterase. Over a culture period of 3 weeks, it was found that the barbiturate exerts a preferential dose-dependent cytotoxic effect on neurons.The expert technical assistance of Miss A. Wolf is appreciated. This work was supported by grant 6-74-27, INSERM (Physiologie et Pathologie du Développement Nerveux). 相似文献
67.
G. G. Jaros M. Sensenbrenner T. C. Downes B. J. Meyer P. Mandel 《Cellular and molecular life sciences : CMLS》1975,31(2):251-253
Résumé Nous avons simplifié la méthode de préparation du substrat «collagène» pour la culture de cellules nerveuses dissociées. On obtient une fixation et une différenciation rapide des cellules sur ce substrat. Les cultures conviennent pour des études morphologiques, biochimiques et électrophysiologiques.
Chargée de Recherche au CNRS.
Acknowledgments. The technical assistance of Mrs.Dorea van Weele andMrs. Marie-France Knoetgen is gratefully acknowledged. 相似文献
Chargée de Recherche au CNRS.
Acknowledgments. The technical assistance of Mrs.Dorea van Weele andMrs. Marie-France Knoetgen is gratefully acknowledged. 相似文献
68.
The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. 总被引:19,自引:0,他引:19
H Mandel R Szargel V Labay O Elpeleg A Saada A Shalata Y Anbinder D Berkowitz C Hartman M Barak S Eriksson N Cohen 《Nature genetics》2001,29(3):337-341
Mitochondrial DNA (mtDNA)-depletion syndromes (MDS; OMIM 251880) are phenotypically heterogeneous, autosomal-recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of MDS have early progressive liver failure and neurological abnormalities, hypoglycemia and increased lactate in body fluids. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes (I, III, IV, V) and mtDNA depletion. We used homozygosity mapping in three kindreds of Druze origin to map the gene causing hepatocerebral MDS to a region of 6.1 cM on chromosome 2p13, between markers D2S291 and D2S2116. This interval encompasses the gene (DGUOK) encoding the mitochondrial deoxyguanosine kinase (dGK). We identified a single-nucleotide deletion (204delA) within the coding region of DGUOK that segregates with the disease in the three kindreds studied. Western-blot analysis did not detect dGK protein in the liver of affected individuals. The main supply of deoxyribonucleotides (dNTPs) for mtDNA synthesis comes from the salvage pathway initiated by dGK and thymidine kinase-2 (TK2). The association of mtDNA depletion with mutated DGUOK suggests that the salvage-pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools. 相似文献
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